Identification and preliminary characterization of protein-cysteine farnesyltransferase - Wikidata - wikimedia - TriplyDB

Identification and preliminary characterization of protein-cysteine farnesyltransferase

Identification and preliminary characterization of protein-cysteine farnesyltransferase

http://www.wikidata.org/entity/Q24557154

about

Geranylgeranyltransferase I inhibitors target RalB to inhibit anchorage-dependent growth and induce apoptosis and RalA to inhibit anchorage-independent growth Purified yeast protein farnesyltransferase is structurally and functionally similar to its mammalian counterpart.Erf2, a novel gene product that affects the localization and palmitoylation of Ras2 in Saccharomyces cerevisiae.Protein geranylgeranyltransferase of Saccharomyces cerevisiae is specific for Cys-Xaa-Xaa-Leu motif proteins and requires the CDC43 gene product but not the DPR1 gene product Protein farnesyltransferase and protein prenylation in Plasmodium falciparum Effect of insulin on farnesyltransferase activity in 3T3-L1 adipocytes Analysis of farnesyl transferase activity during hormone-induced maturation of Xenopus laevis oocytes Inhibition of protein geranylgeranylation causes a superinduction of nitric-oxide synthase-2 by interleukin-1beta in vascular smooth muscle cells Molecular technology and pancreatic cancer.Novel strategies and therapeutics for the treatment of prostate carcinoma.Novel non-operative treatment and treatment strategies in pancreatic cancer.Consumption of oxygen: a mitochondrial-generated progression signal of advanced cancer.Emerging targeted treatments for malignant glioma.Nucleoplasmic localization of prelamin A: implications for prenylation-dependent lamin A assembly into the nuclear lamina Endoproteolytic processing of a farnesylated peptide in vitro.A microsomal endoprotease that specifically cleaves isoprenylated peptides Isoprenoid addition to Ras protein is the critical modification for its membrane association and transforming activity The biochemistry of ras p21.A protein geranylgeranyltransferase from bovine brain: implications for protein prenylation specificity.C terminus of the small GTP-binding protein smg p25A contains two geranylgeranylated cysteine residues and a methyl ester Ribosomal peptide natural products: bridging the ribosomal and nonribosomal worlds.Posttranslational modification of Ha-ras p21 by farnesyl versus geranylgeranyl isoprenoids is determined by the COOH-terminal amino acid Quantitation of prenylcysteines by a selective cleavage reaction Ubiquitin-RAS peptide extensions as substrates for farnesyl-protein transferase and carboxymethyltransferase.Protein lipid modifications--More than just a greasy ballast.The N54 mutant of Galphas has a conditional dominant negative phenotype which suppresses hormone-stimulated but not basal cAMP levels.Ras CAAX peptidomimetic FTI-277 selectively blocks oncogenic Ras signaling by inducing cytoplasmic accumulation of inactive Ras-Raf complexes.Prenylated protein methyltransferases do not distinguish between farnesylated and geranylgeranylated substrates.Manumycin and gliotoxin derivative KT7595 block Ras farnesylation and cell growth but do not disturb lamin farnesylation and localization in human tumour cells.Allosteric modulation of peroxisomal membrane protein recognition by farnesylation of the peroxisomal import receptor PEX19.Effect of the lipid-lowering agent bezafibrate on tumour growth rate in vivo Endoproteolysis of non-CAAX-containing isoprenylated peptides.Exploring the putative self-binding property of the human farnesyltransferase alpha-subunit.Carboxy-terminal CFFL-sequence-specific monomeric protein geranylgeranyltransferase I from the eyes of the shrimp Penaeus japonicus.A single activity carboxyl methylates both farnesyl and geranylgeranyl cysteine residues.

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P2860

Identification and preliminary characterization of protein-cysteine farnesyltransferase

http://www.wikidata.org/entity/Q24557154

description

1990 nî lūn-bûn

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1990 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

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1990 թվականի հոտեմբերին հրատարակված գիտական հոդված

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1990年の論文

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1990年学术文章

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1990年学术文章

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1990年学术文章

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1990年学术文章

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1990年学术文章

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1990年學術文章

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name

Identification and preliminary characterization of protein-cysteine farnesyltransferase

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Identification and preliminary characterization of protein-cysteine farnesyltransferase

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Identification and preliminary characterization of protein-cysteine farnesyltransferase

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type

label

Identification and preliminary characterization of protein-cysteine farnesyltransferase

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Identification and preliminary characterization of protein-cysteine farnesyltransferase

@en

Identification and preliminary characterization of protein-cysteine farnesyltransferase

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prefLabel

Identification and preliminary characterization of protein-cysteine farnesyltransferase

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Identification and preliminary characterization of protein-cysteine farnesyltransferase

@en

Identification and preliminary characterization of protein-cysteine farnesyltransferase

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PNAS.87.19.7541

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Proceedings of the National Academy of Sciences of the United States of America

P1476

Identification and preliminary characterization of protein-cysteine farnesyltransferase

@en

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A Tobin

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B Kurz

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C Meyers

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D Roberts

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E O'Rourke

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H F Kung

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M De Virgilio

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M Resh

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N Ahmed

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V Manne

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P2860

Posttranslational modification of the Ha-ras oncogene protein: evidence for a third class of protein carboxyl methyltransferases

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

All ras proteins are polyisoprenylated but only some are palmitoylated

Regulation of the mevalonate pathway

Post-translational processing of p21ras is two-step and involves carboxyl-methylation and carboxy-terminal proteolysis.

Dynamic fatty acylation of p21N-ras.

Transforming p21 ras protein: flexibility in the major variable region linking the catalytic and membrane-anchoring domains.

Harvey murine sarcoma virus p21 ras protein: biological and biochemical significance of the cysteine nearest the carboxy terminus

Expression of normal and transforming H-ras genes in Escherichia coli and purification of their encoded p21 proteins.

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7541-5

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19

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