Geranylgeranyltransferase I inhibitors target RalB to inhibit anchorage-dependent growth and induce apoptosis and RalA to inhibit anchorage-independent growth
about
Regulation of the Target of Rapamycin and Other Phosphatidylinositol 3-Kinase-Related Kinases by Membrane TargetingRal GTPases: crucial mediators of exocytosis and tumourigenesisRal GTPases in tumorigenesis: emerging from the shadowsAberrant overexpression of the Rgl2 Ral small GTPase-specific guanine nucleotide exchange factor promotes pancreatic cancer growth through Ral-dependent and Ral-independent mechanismsIdentification and characterization of mechanism of action of P61-E7, a novel phosphine catalysis-based inhibitor of geranylgeranyltransferase-IIdentification of a novel prenyl and palmitoyl modification at the CaaX motif of Cdc42 that regulates RhoGDI bindingTargeting protein lipidation in diseasePhosphorylation of RalB is important for bladder cancer cell growth and metastasisIn vivo antitumor effect of a novel inhibitor of protein geranylgeranyltransferase-ISynthesis and screening of a CaaL peptide library versus FTase reveals a surprising number of substratesMeasurement of protein farnesylation and geranylgeranylation in vitro, in cultured cells and in biopsies, and the effects of prenyl transferase inhibitorsTargeting protein prenylation for cancer therapyA novel approach to tag and identify geranylgeranylated proteins.Ral activation promotes melanomagenesis.Combination of farnesyltransferase and Akt inhibitors is synergistic in breast cancer cells and causes significant breast tumor regression in ErbB2 transgenic mice.Ral small GTPase signaling and oncogenesis: More than just 15minutes of fameStructure-based design and synthesis of potent, ethylenediamine-based, mammalian farnesyltransferase inhibitors as anticancer agentsIn vitro and in vivo effects of geranylgeranyltransferase I inhibitor P61A6 on non-small cell lung cancer cellsInhibiting the cyclin-dependent kinase CDK5 blocks pancreatic cancer formation and progression through the suppression of Ras-Ral signalingBlockade of protein geranylgeranylation inhibits Cdk2-dependent p27Kip1 phosphorylation on Thr187 and accumulates p27Kip1 in the nucleus: implications for breast cancer therapy.A combination therapy for KRAS-driven lung adenocarcinomas using lipophilic bisphosphonates and rapamycinThe RalGEF-Ral Effector Signaling Network: The Road Less Traveled for Anti-Ras Drug Discovery.Elevated NIBP/TRAPPC9 mediates tumorigenesis of cancer cells through NFκB signalingDissection of RAS downstream pathways in melanomagenesis: a role for Ral in transformation.Inhibition of Ras for cancer treatment: the search continues.Divergent roles of CAAX motif-signaled posttranslational modifications in the regulation and subcellular localization of Ral GTPases.Differential involvement of RalA and RalB in colorectal cancer.Effects of RAL signal transduction in KRAS- and BRAF-mutated cells and prognostic potential of the RAL signature in colorectal cancerInvolvement of RalB in the effect of geranylgeranyltransferase I on glioma cell migration and invasion.Depletion of K-Ras promotes proteasome degradation of survivinRalA is overactivated in medulloblastoma.Involvement of RhoA and RalB in geranylgeranyltransferase I inhibitor-mediated inhibition of proliferation and migration of human oral squamous cell carcinoma cells.Alkynyl-farnesol reporters for detection of protein S-prenylation in cells.Molecular mechanisms linking geranylgeranyl diphosphate synthase to cell survival and proliferation.Rho Family GTPase modification and dependence on CAAX motif-signaled posttranslational modification.Mechanistic target of rapamycin complex 1 is an essential mediator of metabolic and mitogenic effects of fibroblast growth factor 19 in hepatoma cells.Novel role of Cdc42 and RalA GTPases in TNF-α mediated secretion of CCL2.Ral signaling pathway in health and cancer.RAL GTPases: Biology and Potential as Therapeutic Targets in Cancer.Plasma membrane phosphatidylinositol 4-phosphate and 4,5-bisphosphate determine the distribution and function of K-Ras4B but not H-Ras proteins.
P2860
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P2860
Geranylgeranyltransferase I inhibitors target RalB to inhibit anchorage-dependent growth and induce apoptosis and RalA to inhibit anchorage-independent growth
description
2007 nî lūn-bûn
@nan
2007 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Geranylgeranyltransferase I in ...... t anchorage-independent growth
@ast
Geranylgeranyltransferase I in ...... t anchorage-independent growth
@en
Geranylgeranyltransferase I in ...... t anchorage-independent growth
@en-gb
Geranylgeranyltransferase I in ...... t anchorage-independent growth
@nl
type
label
Geranylgeranyltransferase I in ...... t anchorage-independent growth
@ast
Geranylgeranyltransferase I in ...... t anchorage-independent growth
@en
Geranylgeranyltransferase I in ...... t anchorage-independent growth
@en-gb
Geranylgeranyltransferase I in ...... t anchorage-independent growth
@nl
prefLabel
Geranylgeranyltransferase I in ...... t anchorage-independent growth
@ast
Geranylgeranyltransferase I in ...... t anchorage-independent growth
@en
Geranylgeranyltransferase I in ...... t anchorage-independent growth
@en-gb
Geranylgeranyltransferase I in ...... t anchorage-independent growth
@nl
P2093
P2860
P921
P356
P1476
Geranylgeranyltransferase I in ...... t anchorage-independent growth
@en
P2093
Adrienne D Cox
Andrew D Hamilton
Channing J Der
De-an Wang
Dora Carrico
Hairuo Peng
Samuel C Falsetti
Saïd M Sebti
P2860
P304
P356
10.1128/MCB.00057-07
P407
P577
2007-11-01T00:00:00Z