Activation of RasGRP3 by phosphorylation of Thr-133 is required for B cell receptor-mediated Ras activation
about
A diacylglycerol-protein kinase C-RasGRP1 pathway directs Ras activation upon antigen receptor stimulation of T cells.Structural analysis of autoinhibition in the Ras-specific exchange factor RasGRP1Lipid rafts and B cell signalingUnusual interplay of two types of Ras activators, RasGRP and SOS, establishes sensitive and robust Ras activation in lymphocytesRasGRPs are targets of the anti-cancer agent ingenol-3-angelateCa2+ influx and protein scaffolding via TRPC3 sustain PKCbeta and ERK activation in B cellsDiscovery and characterization of novel vascular and hematopoietic genes downstream of etsrp in zebrafish.Bryostatin analogue-induced apoptosis in mantle cell lymphoma cell linesA novel cross-talk in diacylglycerol signaling: the Rac-GAP beta2-chimaerin is negatively regulated by protein kinase Cdelta-mediated phosphorylationSynthesis, biological, and biophysical studies of DAG-indololactones designed as selective activators of RasGRP.Function of RasGRP3 in the formation and progression of human breast cancerRasGRP3 limits Toll-like receptor-triggered inflammatory response in macrophages by activating Rap1 small GTPase.The Ras activator RasGRP3 mediates diabetes-induced embryonic defects and affects endothelial cell migration.RasGRP3 contributes to formation and maintenance of the prostate cancer phenotype.Whole transcriptome sequencing reveals extensive unspliced mRNA in metastatic castration-resistant prostate cancer.Regulation and Function of the RasGRP Family of Ras Activators in Blood CellsRasGRP3 regulates the migration of glioma cells via interaction with Arp3Wealth of opportunity - the C1 domain as a target for drug development.Dysregulation of RasGRP1 in rheumatoid arthritis and modulation of RasGRP3 as a biomarker of TNFα inhibitors.STIM1, PKC-δ and RasGRP set a threshold for proapoptotic Erk signaling during B cell development.Biochemical characterization of hyperactive beta2-chimaerin mutants revealed an enhanced exposure of C1 and Rac-GAP domains.Localized diacylglycerol-dependent stimulation of Ras and Rap1 during phagocytosis.RasGRP3, a Ras activator, contributes to signaling and the tumorigenic phenotype in human melanoma.Regulation of ras exchange factors and cellular localization of ras activation by lipid messengers in T cells.RasGRP Ras guanine nucleotide exchange factors in cancer.RasGRP3 Mediates MAPK Pathway Activation in GNAQ Mutant Uveal Melanoma.Aberrant expression of RasGRP1 cooperates with gain-of-function NOTCH1 mutations in T-cell leukemogenesis.Differential membrane binding and diacylglycerol recognition by C1 domains of RasGRPs.A novel diacylglycerol-lactone shows marked selectivity in vitro among C1 domains of protein kinase C (PKC) isoforms alpha and delta as well as selectivity for RasGRP compared with PKCalpha.Ca-dependent Ras/Erk signaling mediates negative selection of autoreactive B cells.BLNK binds active H-Ras to promote B cell receptor-mediated capping and ERK activation.A Histidine pH sensor regulates activation of the Ras-specific guanine nucleotide exchange factor RasGRP1.Regulation of RasGRP1 by B cell antigen receptor requires cooperativity between three domains controlling translocation to the plasma membrane.A mutational comparison of adult and adolescent and young adult (AYA) colon cancer.Importance of the REM (Ras exchange) domain for membrane interactions by RasGRP3.GNA11 Q209L Mouse Model Reveals RasGRP3 as an Essential Signaling Node in Uveal Melanoma.Grb2 and GRAP connect the B cell antigen receptor to Erk MAP kinase activation in human B cells.
P2860
Q24302377-B6466D5F-ED6A-41A5-BA8A-FDAA28E63781Q24313621-DAC41BD6-B29A-40A1-8144-D31A1FC13FBBQ24680871-0FF0A5BA-62BA-423C-BCBE-45C09C53342FQ24683597-209597A0-3B58-4EA4-87CB-5A8F0E46DBABQ28535474-24D99C06-0300-4CF1-98A5-6B7E80525F29Q30493465-34A5763C-184F-4C9F-A2B7-46B2212B4DA1Q33420832-819BD07F-8E98-4BCF-86D5-498A71D5F74BQ33760917-A875488A-2E79-4AF2-842D-AD620B450B91Q33883417-8222CAE1-AF49-49BC-9337-C45D2F64270FQ33925381-015F4A5E-2AE3-4861-82B5-E983CE5F8618Q33960160-04B1A0FE-B6FE-40BC-8610-65FE135E4925Q34086384-0120FFFF-0F9E-435F-BAB2-402A6ACA218FQ34176721-4BC6DC30-CD18-4B77-B4BA-897D8A8BCF42Q34203989-716B2225-0D6D-4BAF-BDEB-EB885C69FF86Q35033626-88100BE5-BFAB-4F55-B8AD-B67934CFF216Q35083742-4B55DA76-64B0-440F-9972-0D51641DD079Q35176456-18A4BBBA-9F3B-4801-BBEA-C47D3234E5FFQ36168226-8AD20CB1-FCAD-4718-AE1B-1351670E29ADQ36477380-840D2FB9-990F-4F4D-98C7-8952D024EAF1Q36759087-1C3A51CA-43D4-4CC7-A817-7FCD566FA48BQ37373801-B5492018-B586-407F-B5A9-0B0D9A6FA52FQ37431056-50F831DD-0389-4B8E-B306-F7D3B6DF1498Q37634008-80D71E63-B8D4-4CF1-880C-E723B57DC14BQ38136655-C07B9EFD-7EF8-45F9-9649-0894F6989856Q38205441-A43C9D5A-4CA6-4563-8F89-1E265290A586Q38704201-0995639A-B1A8-4264-B855-BF5DAB646744Q39437389-0B6CB5C7-D560-4549-8271-C58FB63B35A9Q40128306-115CA914-AB0A-467C-A578-6A8CF4D50696Q40415755-0BF8ED8C-3E15-4D46-9F4C-D7BCB4806F3DQ40647123-3D5A91AA-B81A-4E7B-8A1C-23973B90A4C6Q41780823-7DC4EBD8-1385-40F3-B9C1-8681D475FE9EQ42378721-382047BE-7B7C-47D2-B29C-BED8679883EEQ42414565-CA5B8976-F787-480E-A20D-CE43FB02F302Q47342245-8D08F4DA-DF85-412C-9D6A-91FCDDB0C406Q47674282-8114ACAB-CC2B-4381-95BB-55F16A3080B6Q51418687-1AF3D0A8-54B8-4D55-AC14-B5070E5DF904Q54122098-5622BBBB-5582-48A2-9528-89B7217493A4
P2860
Activation of RasGRP3 by phosphorylation of Thr-133 is required for B cell receptor-mediated Ras activation
description
2004 nî lūn-bûn
@nan
2004 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Activation of RasGRP3 by phosp ...... ceptor-mediated Ras activation
@ast
Activation of RasGRP3 by phosp ...... ceptor-mediated Ras activation
@en
Activation of RasGRP3 by phosp ...... ceptor-mediated Ras activation
@nl
type
label
Activation of RasGRP3 by phosp ...... ceptor-mediated Ras activation
@ast
Activation of RasGRP3 by phosp ...... ceptor-mediated Ras activation
@en
Activation of RasGRP3 by phosp ...... ceptor-mediated Ras activation
@nl
prefLabel
Activation of RasGRP3 by phosp ...... ceptor-mediated Ras activation
@ast
Activation of RasGRP3 by phosp ...... ceptor-mediated Ras activation
@en
Activation of RasGRP3 by phosp ...... ceptor-mediated Ras activation
@nl
P2093
P2860
P921
P356
P1476
Activation of RasGRP3 by phosp ...... ceptor-mediated Ras activation
@en
P2093
Atsushi Hijikata
Masatsugu Oh-hora
Shigeki Kiyonaka
Tomohiro Kurosaki
Yasuo Mori
Yayoi Kimura
Yuichi Aiba
P2860
P304
P356
10.1073/PNAS.0407468101
P407
P577
2004-11-23T00:00:00Z