Activation of EVI1 gene expression in human acute myelogenous leukemias by translocations spanning 300-400 kilobases on chromosome band 3q26 - Wikidata - wikimedia - TriplyDB

Activation of EVI1 gene expression in human acute myelogenous leukemias by translocations spanning 300-400 kilobases on chromosome band 3q26

Activation of EVI1 gene expression in human acute myelogenous leukemias by translocations spanning 300-400 kilobases on chromosome band 3q26

http://www.wikidata.org/entity/Q24561670

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The evi-1 oncoprotein inhibits c-Jun N-terminal kinase and prevents stress-induced cell death Evi-1 transforming and repressor activities are mediated by CtBP co-repressor proteins Interaction of EVI1 with cAMP-responsive element-binding protein-binding protein (CBP) and p300/CBP-associated factor (P/CAF) results in reversible acetylation of EVI1 and in co-localization in nuclear speckles Intergenic splicing of MDS1 and EVI1 occurs in normal tissues as well as in myeloid leukemia and produces a new member of the PR domain family UXT interacts with the transcriptional repressor protein EVI1 and suppresses cell transformation SKI and MEL1 cooperate to inhibit transforming growth factor-beta signal in gastric cancer cells Oncogenic transcription factor Evi1 regulates hematopoietic stem cell proliferation through GATA-2 expression Generation of the AML1-EVI-1 fusion gene in the t(3;21)(q26;q22) causes blastic crisis in chronic myelocytic leukemia Meis1, a PBX1-related homeobox gene involved in myeloid leukemia in BXH-2 mice EVI1 promotes cell proliferation by interacting with BRG1 and blocking the repression of BRG1 on E2F1 activity The leukaemia-associated transcription factors EVI-1 and MDS1/EVI1 repress transcription and interact with histone deacetylase Transcriptional repression mediated by the PR domain zinc finger gene RIZ Identification of binding sites of EVI1 in mammalian cells Zinc fingers 1-7 of EVI1 fail to bind to the GATA motif by itself but require the core site GACAAGATA for binding The retinoblastoma interacting zinc finger gene RIZ produces a PR domain-lacking product through an internal promoter A novel interaction between the proto-oncogene Evi1 and histone methyltransferases, SUV39H1 and G9a Acute myeloid leukemia presenting with panhypopituitarism or diabetes insipidus: a case series with molecular genetic analysis and review of the literature.Diabetes insipidus revealing acute myelogenous leukaemia with a high platelet count, monosomy 7 and abnormalities of chromosome 3: a new entity?Genetic abnormalities as targets for molecular therapies in myelodysplastic syndromes.PRDM Proteins: Molecular Mechanisms in Signal Transduction and Transcriptional Regulation.Retroviral insertions in Evi12, a novel common virus integration site upstream of Tra1/Grp94, frequently coincide with insertions in the gene encoding the peripheral cannabinoid receptor Cnr2.Acetylation of lysine 564 adjacent to the C-terminal binding protein-binding motif in EVI1 is crucial for transcriptional activation of GATA2.Molecular characterization of a t(1;3)(p36;q21) in a patient with MDS. MEL1 is widely expressed in normal tissues, including bone marrow, and it is not overexpressed in the t(1;3) cells.Rearrangements of chromosome band 3q21 in myeloid leukemia.Tracking of specific integrant clones in dogs treated with foamy virus vectors.EVI1 inhibits apoptosis induced by antileukemic drugs via upregulation of CDKN1A/p21/WAF in human myeloid cells A rapid RT-PCR based method to isolate complementary DNA fragments flanking retrovirus integration sites.Consistent intergenic splicing and production of multiple transcripts between AML1 at 21q22 and unrelated genes at 3q26 in (3;21)(q26;q22) translocations Translocation t(2;3)(p15-23;q26-27) in myeloid malignancies: report of 21 new cases, clinical, cytogenetic and molecular genetic features.Molecular mechanisms of leukemogenesis by AML1/EVI-1.Insertional mutagenesis identifies genes that promote the immortalization of primary bone marrow progenitor cells Sox4 cooperates with Evi1 in AKXD-23 myeloid tumors via transactivation of proviral LTR.EVI1 acts as an inducible negative-feedback regulator of NF-κB by inhibiting p65 acetylation.Human thrombopoietin: gene structure, cDNA sequence, expression, and chromosomal localization.Expression of the zinc finger gene EVI-1 in ovarian and other cancers.Overexpression of sPRDM16 coupled with loss of p53 induces myeloid leukemias in mice Loss of erythropoietin responsiveness in erythroid progenitors due to expression of the Evi-1 myeloid-transforming gene miR-133 regulates Evi1 expression in AML cells as a potential therapeutic target From hematopoiesis to neuropoiesis: evidence of overlapping genetic programs Dual functions of the AML1/Evi-1 chimeric protein in the mechanism of leukemogenesis in t(3;21) leukemias.

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Activation of EVI1 gene expression in human acute myelogenous leukemias by translocations spanning 300-400 kilobases on chromosome band 3q26

http://www.wikidata.org/entity/Q24561670

description

1992 nî lūn-bûn

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1992 թուականի Մայիսին հրատարակուած գիտական յօդուած

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1992 թվականի մայիսին հրատարակված գիտական հոդված

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1992年の論文

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1992年論文

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1992年論文

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1992年論文

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1992年論文

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1992年論文

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1992年论文

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Activation of EVI1 gene expres ...... obases on chromosome band 3q26

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Activation of EVI1 gene expres ...... obases on chromosome band 3q26

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Activation of EVI1 gene expres ...... obases on chromosome band 3q26

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Activation of EVI1 gene expres ...... obases on chromosome band 3q26

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Activation of EVI1 gene expres ...... obases on chromosome band 3q26

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Activation of EVI1 gene expres ...... obases on chromosome band 3q26

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Activation of EVI1 gene expres ...... obases on chromosome band 3q26

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Activation of EVI1 gene expres ...... obases on chromosome band 3q26

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Activation of EVI1 gene expres ...... obases on chromosome band 3q26

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Proceedings of the National Academy of Sciences of the United States of America

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Activation of EVI1 gene expres ...... obases on chromosome band 3q26

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C L William

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P2860

Site-specific recombination of the tal-1 gene is a common occurrence in human T cell leukemia

Regional localization of chromosome 3-specific DNA fragments by using a hybrid cell deletion mapping panel

CpG-rich islands and the function of DNA methylation

A novel cyclin encoded by a bcl1-linked candidate oncogene

Retroviral activation of a novel gene encoding a zinc finger protein in IL-3-dependent myeloid leukemia cell lines

Unique expression of the human Evi-1 gene in an endometrial carcinoma cell line: sequence of cDNAs and structure of alternatively spliced transcripts

Identification, nuclear localization, and DNA-binding activity of the zinc finger protein encoded by the Evi-1 myeloid transforming gene

Retroviral insertions 90 kilobases proximal to the Evi-1 myeloid transforming gene activate transcription from the normal promoter

Evi-1, a murine zinc finger proto-oncogene, encodes a sequence-specific DNA-binding protein.

Three breakpoints of variant t(2;8) translocations in Burkitt's lymphoma cells fall within a region 140 kilobases distal from c-myc.

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