Evi-1, a murine zinc finger proto-oncogene, encodes a sequence-specific DNA-binding protein.
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Phosphorylation of the leukemic oncoprotein EVI1 on serine 196 modulates DNA binding, transcriptional repression and transforming abilityInteraction of EVI1 with cAMP-responsive element-binding protein-binding protein (CBP) and p300/CBP-associated factor (P/CAF) results in reversible acetylation of EVI1 and in co-localization in nuclear specklesAn exceptionally conserved transcriptional repressor, CTCF, employs different combinations of zinc fingers to bind diverged promoter sequences of avian and mammalian c-myc oncogenesPbx1 is a downstream target of Evi-1 in hematopoietic stem/progenitors and leukemic cellsThe ZNF35 human zinc finger gene encodes a sequence-specific DNA-binding proteinActivation of a novel proto-oncogene, Frat1, contributes to progression of mouse T-cell lymphomas.Activation of EVI1 gene expression in human acute myelogenous leukemias by translocations spanning 300-400 kilobases on chromosome band 3q26Specific association between the human DNA repair proteins XPA and ERCC1Generation of the AML1-EVI-1 fusion gene in the t(3;21)(q26;q22) causes blastic crisis in chronic myelocytic leukemiaOf the GATA-binding proteins, only GATA-4 selectively regulates the human interleukin-5 gene promoter in interleukin-5-producing cells which express multiple GATA-binding proteinsIdentification of binding sites of EVI1 in mammalian cellsZinc fingers 1-7 of EVI1 fail to bind to the GATA motif by itself but require the core site GACAAGATA for bindingMutation at the Evi1 locus in Junbo mice causes susceptibility to otitis mediaPrdm16 is required for normal palatogenesis in mice.RUNX1-ETO and RUNX1-EVI1 Differentially Reprogram the Chromatin Landscape in t(8;21) and t(3;21) AML.Acetylation of lysine 564 adjacent to the C-terminal binding protein-binding motif in EVI1 is crucial for transcriptional activation of GATA2.GATA motifs regulate early hematopoietic lineage-specific expression of the Gata2 gene.Expression of myelin transcription factor I (MyTI), a "zinc-finger" DNA-binding protein, in developing oligodendrocytes.Aberrant DNA hypermethylation signature in acute myeloid leukemia directed by EVI1.Global Identification of EVI1 Target Genes in Acute Myeloid Leukemia.Deletion of Mecom in mouse results in early-onset spinal deformity and osteopenia.Mutational spectrum of myeloid malignancies with inv(3)/t(3;3) reveals a predominant involvement of RAS/RTK signaling pathways.Mice carrying a hypomorphic Evi1 allele are embryonic viable but exhibit severe congenital heart defectsA consensus sequence for binding of Lrp to DNA.Sox4 cooperates with Evi1 in AKXD-23 myeloid tumors via transactivation of proviral LTR.EVI1 acts as an inducible negative-feedback regulator of NF-κB by inhibiting p65 acetylation.EVI1 is critical for the pathogenesis of a subset of MLL-AF9-rearranged AMLs.Expression of the zinc finger gene EVI-1 in ovarian and other cancers.Loss of erythropoietin responsiveness in erythroid progenitors due to expression of the Evi-1 myeloid-transforming geneCharacterization of the DNA-binding properties of the myeloid zinc finger protein MZF1: two independent DNA-binding domains recognize two DNA consensus sequences with a common G-rich core.Four of the seven zinc fingers of the Evi-1 myeloid-transforming gene are required for sequence-specific binding to GA(C/T)AAGA(T/C)AAGATAA.Targeting a DNA binding motif of the EVI1 protein by a pyrrole-imidazole polyamide.A mouse oocyte-specific protein that binds to a region of mZP3 promoter responsible for oocyte-specific mZP3 gene expressionExpression of the Evi-1 zinc finger gene in 32Dc13 myeloid cells blocks granulocytic differentiation in response to granulocyte colony-stimulating factor.EVI1 Interferes with Myeloid Maturation via Transcriptional Repression of Cebpa, via Binding to Two Far Downstream Regulatory Elements.Disease-specific motifs can be identified in circulating nucleic acids from live elk and cattle infected with transmissible spongiform encephalopathies.Pathogenetic significance of ecotropic viral integration site-1 in hematological malignancies.Protein-DNA binding: complexities and multi-protein codes.EVI1 promotes tumor growth via transcriptional repression of MS4A3.Broad binding-site specificity and affinity properties of octamer 1 and brain octamer-binding proteins.
P2860
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P2860
Evi-1, a murine zinc finger proto-oncogene, encodes a sequence-specific DNA-binding protein.
description
1991 nî lūn-bûn
@nan
1991年の論文
@ja
1991年論文
@yue
1991年論文
@zh-hant
1991年論文
@zh-hk
1991年論文
@zh-mo
1991年論文
@zh-tw
1991年论文
@wuu
1991年论文
@zh
1991年论文
@zh-cn
name
Evi-1, a murine zinc finger pr ...... -specific DNA-binding protein.
@ast
Evi-1, a murine zinc finger pr ...... -specific DNA-binding protein.
@en
type
label
Evi-1, a murine zinc finger pr ...... -specific DNA-binding protein.
@ast
Evi-1, a murine zinc finger pr ...... -specific DNA-binding protein.
@en
prefLabel
Evi-1, a murine zinc finger pr ...... -specific DNA-binding protein.
@ast
Evi-1, a murine zinc finger pr ...... -specific DNA-binding protein.
@en
P2093
P2860
P356
P1476
Evi-1, a murine zinc finger pr ...... -specific DNA-binding protein.
@en
P2093
A S Perkins
N A Jenkins
N G Copeland
P2860
P304
P356
10.1128/MCB.11.5.2665
P407
P577
1991-05-01T00:00:00Z