Reversal of hypertriglyceridemia, fatty liver disease, and insulin resistance by a liver-targeted mitochondrial uncoupler
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INTERACTING DISCIPLINES: Cardiac natriuretic peptides and obesity: perspectives from an endocrinologist and a cardiologistBGP-15 Protects against Oxidative Stress- or Lipopolysaccharide-Induced Mitochondrial Destabilization and Reduces Mitochondrial Production of Reactive Oxygen SpeciesTreatment of nonalcoholic fatty liver disease: role of AMPK.Hepatic Diacylglycerol-Associated Protein Kinase Cε Translocation Links Hepatic Steatosis to Hepatic Insulin Resistance in Humans.The chemical uncoupler 2,4-dinitrophenol (DNP) protects against diet-induced obesity and improves energy homeostasis in mice at thermoneutralityControlled-release mitochondrial protonophore reverses diabetes and steatohepatitis in rats.Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents.Mitochondrial dysfunction and insulin resistance: an update.Niclosamide ethanolamine-induced mild mitochondrial uncoupling improves diabetic symptoms in mice.Weight loss by Ppc-1, a novel small molecule mitochondrial uncoupler derived from slime moldLeptin reverses diabetes by suppression of the hypothalamic-pituitary-adrenal axisOXPHOS-Mediated Induction of NAD+ Promotes Complete Oxidation of Fatty Acids and Interdicts Non-Alcoholic Fatty Liver Disease.The role of hepatic lipids in hepatic insulin resistance and type 2 diabetesHepatic acetyl CoA links adipose tissue inflammation to hepatic insulin resistance and type 2 diabetesThe mitochondrial uncoupler DNP triggers brain cell mTOR signaling network reprogramming and CREB pathway up-regulationMitochondrial uncoupler carbonyl cyanide m-chlorophenylhydrazone induces vasorelaxation without involving KATP channel activation in smooth muscle cells of arteriesAntiinfectives targeting enzymes and the proton motive force.The pathogenesis of insulin resistance: integrating signaling pathways and substrate fluxGrowth differentiation factor 15 is a myomitokine governing systemic energy homeostasis.Niclosamide piperazine prevents high-fat diet-induced obesity and diabetic symptoms in mice.Loss of Hepatic Mitochondrial Long-Chain Fatty Acid Oxidation Confers Resistance to Diet-Induced Obesity and Glucose Intolerance.Roles of Diacylglycerols and Ceramides in Hepatic Insulin Resistance.Targeting adipose tissue in the treatment of obesity-associated diabetes.Targeting hepatic glucose metabolism in the treatment of type 2 diabetes.Combatting type 2 diabetes by turning up the heat.DNP, mitochondrial uncoupling, and neuroprotection: A little dab'll do ya.Regulation of hepatic glucose metabolism in health and disease.Metformin directly acts on mitochondria to alter cellular bioenergetics.Non-invasive assessment of hepatic mitochondrial metabolism by positional isotopomer NMR tracer analysis (PINTA).The Multifaceted Roles of Adipose Tissue-Therapeutic Targets for Diabetes and Beyond: The 2015 Banting Lecture.Effects of acute hyperinsulinemia on skeletal muscle mitochondrial function, reactive oxygen species production, and metabolism in premenopausal women.The unintended mitochondrial uncoupling effects of the FDA-approved anti-helminth drug nitazoxanide mitigates experimental parkinsonism in mice.Mitochondrial-Targeted Catalase Protects Against High-Fat Diet-Induced Muscle Insulin Resistance by Decreasing Intramuscular Lipid Accumulation.In adipose tissue, increased mitochondrial emission of reactive oxygen species is important for short-term high-fat diet-induced insulin resistance in mice.Mechanism by which arylamine N-acetyltransferase 1 ablation causes insulin resistance in mice.Fatty acid oxidation is required for active and quiescent brown adipose tissue maintenance and thermogenic programing.Nonalcoholic Fatty Liver Disease as a Nexus of Metabolic and Hepatic Diseases.Pharmacological modulation of mitochondrial calcium homeostasis.Use the Protonmotive Force: Mitochondrial Uncoupling and Reactive Oxygen Species.Deep fried edible oils disturb hepatic redox equilibrium and heightens lipotoxicity and hepatosteatosis in male Wistar rats.
P2860
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P2860
Reversal of hypertriglyceridemia, fatty liver disease, and insulin resistance by a liver-targeted mitochondrial uncoupler
description
2013 nî lūn-bûn
@nan
2013 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Reversal of hypertriglyceridem ...... rgeted mitochondrial uncoupler
@ast
Reversal of hypertriglyceridem ...... rgeted mitochondrial uncoupler
@en
Reversal of hypertriglyceridem ...... rgeted mitochondrial uncoupler
@nl
type
label
Reversal of hypertriglyceridem ...... rgeted mitochondrial uncoupler
@ast
Reversal of hypertriglyceridem ...... rgeted mitochondrial uncoupler
@en
Reversal of hypertriglyceridem ...... rgeted mitochondrial uncoupler
@nl
prefLabel
Reversal of hypertriglyceridem ...... rgeted mitochondrial uncoupler
@ast
Reversal of hypertriglyceridem ...... rgeted mitochondrial uncoupler
@en
Reversal of hypertriglyceridem ...... rgeted mitochondrial uncoupler
@nl
P2093
P2860
P50
P921
P1433
P1476
Reversal of hypertriglyceridem ...... rgeted mitochondrial uncoupler
@en
P2093
David A Spiegel
Dominik Pesta
Dongyan Zhang
Gary W Cline
Rachel J Perry
Taehan Kim
Violeta B Popov
Xian-Man Zhang
Yasmeen Rahimi
P2860
P304
P356
10.1016/J.CMET.2013.10.004
P407
P577
2013-11-05T00:00:00Z