sameAs
Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenaseThe Contribution of Blood Lactate to Brain Energy Metabolism in Humans Measured by Dynamic 13C Nuclear Magnetic Resonance SpectroscopyDisruption of IRS-2 causes type 2 diabetes in miceAMP kinase is required for mitochondrial biogenesis in skeletal muscle in response to chronic energy deprivation.Increased energy expenditure, decreased adiposity, and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1B-deficient miceReversal of hypertriglyceridemia, fatty liver disease, and insulin resistance by a liver-targeted mitochondrial uncouplerMechanism of free fatty acid-induced insulin resistance in humansAltered brain mitochondrial metabolism in healthy aging as assessed by in vivo magnetic resonance spectroscopyApolipoprotein C3 gene variants in nonalcoholic fatty liver diseaseFGF19 as a postprandial, insulin-independent activator of hepatic protein and glycogen synthesisGene knockout of Acc2 has little effect on body weight, fat mass, or food intakeAdPLA ablation increases lipolysis and prevents obesity induced by high-fat feeding or leptin deficiencyTissue-specific overexpression of lipoprotein lipase causes tissue-specific insulin resistanceMolecular mechanisms of insulin resistance in humans and their potential links with mitochondrial dysfunctionPhosphoenolpyruvate cycling via mitochondrial phosphoenolpyruvate carboxykinase links anaplerosis and mitochondrial GTP with insulin secretionDecreased insulin-stimulated ATP synthesis and phosphate transport in muscle of insulin-resistant offspring of type 2 diabetic parentsMechanism by which high-dose aspirin improves glucose metabolism in type 2 diabetesAdipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liverMitochondrial dysfunction due to long-chain Acyl-CoA dehydrogenase deficiency causes hepatic steatosis and hepatic insulin resistanceAcetylation of TUG protein promotes the accumulation of GLUT4 glucose transporters in an insulin-responsive intracellular compartmentGlucose toxicity and the development of diabetes in mice with muscle-specific inactivation of GLUT4Contrasting effects of fish oil and safflower oil on hepatic peroxisomal and tissue lipid contentPrevention of fat-induced insulin resistance by salicylateInsulin/IGF-1 and TNF-alpha stimulate phosphorylation of IRS-1 at inhibitory Ser307 via distinct pathwaysEffect of triiodothyronine on mitochondrial energy coupling in human skeletal muscleOverexpression of the LAR (leukocyte antigen-related) protein-tyrosine phosphatase in muscle causes insulin resistanceA prevalent variant in PPP1R3A impairs glycogen synthesis and reduces muscle glycogen content in humans and miceMitochondrial glycerol-3-phosphate acyltransferase-1 is essential in liver for the metabolism of excess acyl-CoAsInflammasome-mediated dysbiosis regulates progression of NAFLD and obesityInhibition of protein kinase Cepsilon prevents hepatic insulin resistance in nonalcoholic fatty liver diseaseMitochondrial GTP regulates glucose-stimulated insulin secretionSuppression of diacylglycerol acyltransferase-2 (DGAT2), but not DGAT1, with antisense oligonucleotides reverses diet-induced hepatic steatosis and insulin resistanceReduced heart size and increased myocardial fuel substrate oxidation in ACC2 mutant miceDual role of proapoptotic BAD in insulin secretion and beta cell survivalInactivation of fatty acid transport protein 1 prevents fat-induced insulin resistance in skeletal musclePrevention of hepatic steatosis and hepatic insulin resistance in mitochondrial acyl-CoA:glycerol-sn-3-phosphate acyltransferase 1 knockout miceDisruption of neural signal transducer and activator of transcription 3 causes obesity, diabetes, infertility, and thermal dysregulationAcetate mediates a microbiome-brain-β-cell axis to promote metabolic syndromeNeuronal UCP1 expression suggests a mechanism for local thermogenesis during hibernation.Lysophosphatidic acid activates peroxisome proliferator activated receptor-γ in CHO cells that over-express glycerol 3-phosphate acyltransferase-1
P50
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P50
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US-amerikanischer Diabetologe und Stoffwechselphysiologe
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diabetólogu estauxunidense
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hulumtues
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onderzoeker uit Verenigde Staten van Amerika
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researcher
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ricercatore
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հետազոտող
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Gerald I Shulman
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Gerald I Shulman
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Gerald I. Shulman
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Gerald I. Shulman
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Gerald I. Shulman
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Gerald I. Shulman
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Gerald I Shulman
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Gerald I Shulman
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Gerald Shulman
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Shulman G
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Shulman G. I.
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Gerald I Shulman
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Gerald I Shulman
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Gerald I. Shulman
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Gerald I. Shulman
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Gerald I. Shulman
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Gerald I. Shulman
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Gerald I. Shulman
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Gerald I. Shulman
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1953-01-01T00:00:00Z
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