Toward a code for the interactions of zinc fingers with DNA: selection of randomized fingers displayed on phage
about
Nucleotides of transcription factor binding sites exert interdependent effects on the binding affinities of transcription factorsRepression of the HIV-1 5' LTR promoter and inhibition of HIV-1 replication by using engineered zinc-finger transcription factorsHybrid restriction enzymes: zinc finger fusions to Fok I cleavage domainComputational prediction of transcription-factor binding site locationsTherapeutic modulation of endogenous gene function by agents with designed DNA-sequence specificitiesToward controlling gene expression at will: specific regulation of the erbB-2/HER-2 promoter by using polydactyl zinc finger proteins constructed from modular building blocksA rapid, generally applicable method to engineer zinc fingers illustrated by targeting the HIV-1 promoterPositive and negative regulation of endogenous genes by designed transcription factorsToward controlling gene expression at will: selection and design of zinc finger domains recognizing each of the 5'-GNN-3' DNA target sequencesDesign of polydactyl zinc-finger proteins for unique addressing within complex genomesFrom sequence to structure and back again: approaches for predicting protein-DNA bindingQuantitative evaluation of protein-DNA interactions using an optimized knowledge-based potentialAn overview of the structures of protein-DNA complexesAb initio prediction of transcription factor targets using structural knowledge.Quantitative analysis of EGR proteins binding to DNA: assessing additivity in both the binding site and the protein.Genome Engineering with TALE and CRISPR Systems in NeuroscienceGenome-editing Technologies for Gene and Cell TherapyNuclease Target Site Selection for Maximizing On-target Activity and Minimizing Off-target Effects in Genome EditingOrigins of Programmable Nucleases for Genome EngineeringProtein design: toward functional metalloenzymesNew Insights into DNA Recognition by Zinc Fingers Revealed by Structural Analysis of the Oncoprotein ZNF217Engineering polydactyl zinc-finger transcription factorsUtrophin up-regulation by an artificial transcription factor in transgenic miceAccelerated evolution of the Prdm9 speciation gene across diverse metazoan taxaEvolutionary expansion and divergence in the ZNF91 subfamily of primate-specific zinc finger genesExtensive protein and DNA backbone sampling improves structure-based specificity prediction for C2H2 zinc fingers.Phage-displayed peptide libraries.DNA-protein interactions: methods for detection and analysis.Targeted methylation of the epithelial cell adhesion molecule (EpCAM) promoter to silence its expression in ovarian cancer cellsPhenotypic alteration of eukaryotic cells using randomized libraries of artificial transcription factors.Tailor-made zinc-finger transcription factors activate FLO11 gene expression with phenotypic consequences in the yeast Saccharomyces cerevisiae.Evolutionary models for formation of network motifs and modularity in the Saccharomyces transcription factor network.Characterization of Drosophila OVO protein DNA binding specificity using random DNA oligomer selection suggests zinc finger degeneration.Nucleating the assembly of macromolecular complexes.Specificity landscapes of DNA binding molecules elucidate biological functionSelection of peptides that functionally replace a zinc finger in the Sp1 transcription factor by using a yeast combinatorial library.Requirements for double-strand cleavage by chimeric restriction enzymes with zinc finger DNA-recognition domainsHistone acetyltransferase activity of p300 is required for transcriptional repression by the promyelocytic leukemia zinc finger protein.Stimulation of homologous recombination through targeted cleavage by chimeric nucleases.Zinc-finger nucleases as a novel therapeutic strategy for targeting hepatitis B virus DNAs.
P2860
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P2860
Toward a code for the interactions of zinc fingers with DNA: selection of randomized fingers displayed on phage
description
1994 nî lūn-bûn
@nan
1994 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1994 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
name
Toward a code for the interact ...... zed fingers displayed on phage
@ast
Toward a code for the interact ...... zed fingers displayed on phage
@en
Toward a code for the interact ...... zed fingers displayed on phage
@nl
type
label
Toward a code for the interact ...... zed fingers displayed on phage
@ast
Toward a code for the interact ...... zed fingers displayed on phage
@en
Toward a code for the interact ...... zed fingers displayed on phage
@nl
prefLabel
Toward a code for the interact ...... zed fingers displayed on phage
@ast
Toward a code for the interact ...... zed fingers displayed on phage
@en
Toward a code for the interact ...... zed fingers displayed on phage
@nl
P2860
P3181
P356
P1476
Toward a code for the interact ...... zed fingers displayed on phage
@en
P2860
P304
P3181
P356
10.1073/PNAS.91.23.11163
P407
P577
1994-11-08T00:00:00Z