Recruitment of hepatocyte nuclear factor 4 into specific intranuclear compartments depends on tyrosine phosphorylation that affects its DNA-binding and transactivation potential
about
Expression and localization of P1 promoter-driven hepatocyte nuclear factor-4alpha (HNF4alpha) isoforms in human and ratsThe intracellular localization of deoxycytidine kinaseAn alternative splice variant of the tissue specific transcription factor HNF4alpha predominates in undifferentiated murine cell typesCloning and characterization of mouse deoxyguanosine kinase. Evidence for a cytoplasmic isoformLigand specificity and conformational dependence of the hepatic nuclear factor-4alpha (HNF-4alpha ).Liver enriched transcription factors and differentiation of hepatocellular carcinomaNuclear receptors: mediators and modifiers of inflammation-induced cholestasis.Proteomic analysis of native hepatocyte nuclear factor-4α (HNF4α) isoforms, phosphorylation status, and interactive cofactors.Bile acids and cytokines inhibit the human cholesterol 7 alpha-hydroxylase gene via the JNK/c-jun pathway in human liver cellsQuantitative analysis of cytokine-induced hepatocyte nuclear factor-4α phosphorylation by mass spectrometry.Activation of bile acid biosynthesis by the p38 mitogen-activated protein kinase (MAPK): hepatocyte nuclear factor-4alpha phosphorylation by the p38 MAPK is required for cholesterol 7alpha-hydroxylase expressionROCK inhibition enhances microRNA function by promoting deadenylation of targeted mRNAs via increasing PAIP2 expressionSubnuclear compartmentalization of sequence-specific transcription factors and regulation of eukaryotic gene expression.Activity-dependent nuclear translocation and intranuclear distribution of NFATc in adult skeletal muscle fibersProtein kinase A-dependent phosphorylation modulates DNA-binding activity of hepatocyte nuclear factor 4.Visualization of glucocorticoid receptor translocation and intranuclear organization in living cells with a green fluorescent protein chimera.Cell signaling and nuclear receptors: new opportunities for molecular pharmaceuticals in liver disease.Hepatocyte nuclear factor 4-alpha involvement in liver and intestinal inflammatory networksHepatocyte nuclear factor-4α, a multifunctional nuclear receptor associated with cardiovascular disease and cholesterol catabolism.Members of the nuclear factor 1 family and hepatocyte nuclear factor 4 bind to overlapping sequences of the L-II element on the rat pyruvate kinase L gene promoter and regulate its expression.Role of hepatocyte nuclear factor 4α (HNF4α) in cell proliferation and cancer.Mitogen-activated protein kinase-mediated disruption of enhancer-promoter communication inhibits hepatocyte nuclear factor 4alpha expression.Regulatory mechanisms controlling human hepatocyte nuclear factor 4alpha gene expression.Chicken ovalbumin upstream promoter transcription factors act as auxiliary cofactors for hepatocyte nuclear factor 4 and enhance hepatic gene expression.Liver-enriched transcription factors uncoupled from expression of hepatic functions in hepatoma cell lines.Hepatocyte nuclear factor-4 mediates apolipoprotein A-IV transcriptional regulation by fatty acid in newborn swine enterocytes.Phosphorylation of Ser158 regulates inflammatory redox-dependent hepatocyte nuclear factor-4alpha transcriptional activity.Cytokine regulation of human sterol 12alpha-hydroxylase (CYP8B1) gene.The G115S mutation associated with maturity-onset diabetes of the young impairs hepatocyte nuclear factor 4alpha activities and introduces a PKA phosphorylation site in its DNA-binding domain.The activity of the activation function 2 of the human hepatocyte nuclear factor 4 (HNF-4alpha) is differently modulated by F domains from various origins.An array of binding sites for hepatocyte nuclear factor 4 of high and low affinities modulates the liver-specific enhancer for the human alpha1-microglobulin/bikunin precursor.Activation of CAAT enhancer-binding protein delta (C/EBPdelta) by interleukin-1 negatively influences apolipoprotein C-III expression.Characterization of the human cytochrome P4502D6 promoter. A potential role for antagonistic interactions between members of the nuclear receptor family.The hepatitis B virus (HBV) HBx protein activates AKT to simultaneously regulate HBV replication and hepatocyte survival.Hepatocyte nuclear factor 4 response to injury involves a rapid decrease in DNA binding and transactivation via a JAK2 signal transduction pathway.Role of HNF4alpha in the superinduction of the IL-1beta-activated iNOS gene by oxidative stressIdentification and characterization of cis-acting elements conferring insulin responsiveness on hamster cholesterol 7alpha-hydroxylase gene promoter.Serine/threonine phosphorylation regulates HNF-4alpha-dependent redox-mediated iNOS expression in hepatocytes.AMP-activated protein kinase regulates HNF4alpha transcriptional activity by inhibiting dimer formation and decreasing protein stability.Coordinated control of cholesterol catabolism to bile acids and of gluconeogenesis via a novel mechanism of transcription regulation linked to the fasted-to-fed cycle.
P2860
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P2860
Recruitment of hepatocyte nuclear factor 4 into specific intranuclear compartments depends on tyrosine phosphorylation that affects its DNA-binding and transactivation potential
description
1995 nî lūn-bûn
@nan
1995 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
name
Recruitment of hepatocyte nucl ...... and transactivation potential
@ast
Recruitment of hepatocyte nucl ...... and transactivation potential
@en
Recruitment of hepatocyte nucl ...... and transactivation potential
@nl
type
label
Recruitment of hepatocyte nucl ...... and transactivation potential
@ast
Recruitment of hepatocyte nucl ...... and transactivation potential
@en
Recruitment of hepatocyte nucl ...... and transactivation potential
@nl
prefLabel
Recruitment of hepatocyte nucl ...... and transactivation potential
@ast
Recruitment of hepatocyte nucl ...... and transactivation potential
@en
Recruitment of hepatocyte nucl ...... and transactivation potential
@nl
P2093
P2860
P356
P1476
Recruitment of hepatocyte nucl ...... and transactivation potential
@en
P2093
E Ktistaki
E Papadogeorgaki
N T Ktistakis
P2860
P304
P356
10.1073/PNAS.92.21.9876
P407
P577
1995-10-10T00:00:00Z