Human geminin promotes pre-RC formation and DNA replication by stabilizing CDT1 in mitosis - Wikidata - wikimedia - TriplyDB

Human geminin promotes pre-RC formation and DNA replication by stabilizing CDT1 in mitosis

Human geminin promotes pre-RC formation and DNA replication by stabilizing CDT1 in mitosis

http://www.wikidata.org/entity/Q24563189

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Identification and characterization of a novel component of the human minichromosome maintenance complex Cdt1 associates dynamically with chromatin throughout G1 and recruits Geminin onto chromatin Idas, a novel phylogenetically conserved geminin-related protein, binds to geminin and is required for cell cycle progression Characterization of E2F8, a novel E2F-like cell-cycle regulated repressor of E2F-activated transcription.Cyclin F-mediated degradation of ribonucleotide reductase M2 controls genome integrity and DNA repair Geminin regulates neuronal differentiation by antagonizing Brg1 activity Genome-wide mapping of DNA synthesis in Saccharomyces cerevisiae reveals that mechanisms preventing reinitiation of DNA replication are not redundant.Differentiation of trophoblast stem cells into giant cells is triggered by p57/Kip2 inhibition of CDK1 activity Selective killing of cancer cells by suppression of geminin activity Preventing re-replication of chromosomal DNA.Functional domains of the Xenopus replication licensing factor Cdt1 Ring of Change: CDC48/p97 Drives Protein Dynamics at Chromatin The Non-Canonical Role of Aurora-A in DNA Replication Genomic instability in cancer.Quaternary structure of the human Cdt1-Geminin complex regulates DNA replication licensing Regulation and Function of Cdt1; A Key Factor in Cell Proliferation and Genome Stability HBO1 histone acetylase activity is essential for DNA replication licensing and inhibited by Geminin Origin recognition and the chromosome cycle Aurora-A controls pre-replicative complex assembly and DNA replication by stabilizing geminin in mitosis.Stress-stimulated mitogen-activated protein kinases control the stability and activity of the Cdt1 DNA replication licensing factor Chromatin unfolding by Cdt1 regulates MCM loading via opposing functions of HBO1 and HDAC11-geminin.Acetylation/deacetylation modulates the stability of DNA replication licensing factor Cdt1.Ubiquitylation, phosphorylation and Orc2 modulate the subcellular location of Orc1 and prevent it from inducing apoptosis Persistent telomere damage induces bypass of mitosis and tetraploidy.Replication licensing and the DNA damage checkpoint.CDK1-dependent inhibition of the E3 ubiquitin ligase CRL4CDT2 ensures robust transition from S Phase to Mitosis.A Cdt1-geminin complex licenses chromatin for DNA replication and prevents rereplication during S phase in Xenopus.Cell cycle adaptations of embryonic stem cells.Regulation of cell cycle progression by forkhead transcription factor FOXO3 through its binding partner DNA replication factor Cdt1.Cdc6 stability is regulated by the Huwe1 ubiquitin ligase after DNA damage Manipulation of Cell Cycle and Chromatin Configuration by Means of Cell-Penetrating Geminin The ATR-mediated S phase checkpoint prevents rereplication in mammalian cells when licensing control is disrupted.CDC-48/p97 coordinates CDT-1 degradation with GINS chromatin dissociation to ensure faithful DNA replication."The Octet": Eight Protein Kinases that Control Mammalian DNA Replication.Revoking the cellular license to replicate: yet another AAA assignment.Re-replication induced by geminin depletion occurs from G2 and is enhanced by checkpoint activation.Role of dual specificity tyrosine-phosphorylation-regulated kinase 1B (Dyrk1B) in S-phase entry of HPV E7 expressing cells from quiescence Human papillomavirus E7 induces rereplication in response to DNA damage Scmh1 has E3 ubiquitin ligase activity for geminin and histone H2A and regulates geminin stability directly or indirectly via transcriptional repression of Hoxa9 and Hoxb4 Deregulated expression of Cdc6 in the skin facilitates papilloma formation and affects the hair growth cycle.

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Human geminin promotes pre-RC formation and DNA replication by stabilizing CDT1 in mitosis

http://www.wikidata.org/entity/Q24563189

description

2004 nî lūn-bûn

@nan

2004 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2004 թվականի օգոստոսին հրատարակված գիտական հոդված

@hy

2004年の論文

@ja

2004年学术文章

@wuu

2004年学术文章

@zh-cn

2004年学术文章

@zh-hans

2004年学术文章

@zh-my

2004年学术文章

@zh-sg

2004年學術文章

@yue

name

Human geminin promotes pre-RC ...... by stabilizing CDT1 in mitosis

@ast

Human geminin promotes pre-RC ...... by stabilizing CDT1 in mitosis

@en

Human geminin promotes pre-RC ...... by stabilizing CDT1 in mitosis

@nl

type

label

Human geminin promotes pre-RC ...... by stabilizing CDT1 in mitosis

@ast

Human geminin promotes pre-RC ...... by stabilizing CDT1 in mitosis

@en

Human geminin promotes pre-RC ...... by stabilizing CDT1 in mitosis

@nl

prefLabel

Human geminin promotes pre-RC ...... by stabilizing CDT1 in mitosis

@ast

Human geminin promotes pre-RC ...... by stabilizing CDT1 in mitosis

@en

Human geminin promotes pre-RC ...... by stabilizing CDT1 in mitosis

@nl

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SJ.EMBOJ.7600314

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The EMBO Journal

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Human geminin promotes pre-RC ...... by stabilizing CDT1 in mitosis

@en

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Andrea Ballabeni

http://www.w3.org/2001/XMLSchema#string

Federica Marinoni

http://www.w3.org/2001/XMLSchema#string

Laura Masiero

http://www.w3.org/2001/XMLSchema#string

Marina Melixetian

http://www.w3.org/2001/XMLSchema#string

Raffaella Zamponi

http://www.w3.org/2001/XMLSchema#string

P2860

Inhibition of eukaryotic DNA replication by geminin binding to Cdt1

Geminin, an inhibitor of DNA replication, is degraded during mitosis

Direct interaction of geminin and Six3 in eye development

Cdt1 phosphorylation by cyclin A-dependent kinases negatively regulates its function without affecting geminin binding

Mammalian Cdc7-Dbf4 protein kinase complex is essential for initiation of DNA replication

Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization

Making sense of eukaryotic DNA replication origins.

Stability, chromatin association and functional activity of mammalian pre-replication complex proteins during the cell cycle

Binding of cyclin-dependent kinases to ORC and Cdc6p regulates the chromosome replication cycle

Initiation complex assembly at budding yeast replication origins begins with the recognition of a bipartite sequence by limiting amounts of the initiator, ORC

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10.1038/SJ.EMBOJ.7600314

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15

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23

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8452867

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15257290

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514931

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