A Cdt1-geminin complex licenses chromatin for DNA replication and prevents rereplication during S phase in Xenopus. - Wikidata - wikimedia - TriplyDB

A Cdt1-geminin complex licenses chromatin for DNA replication and prevents rereplication during S phase in Xenopus.

A Cdt1-geminin complex licenses chromatin for DNA replication and prevents rereplication during S phase in Xenopus.

http://www.wikidata.org/entity/Q35222221

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Cdt1 associates dynamically with chromatin throughout G1 and recruits Geminin onto chromatin MCM-BP regulates unloading of the MCM2-7 helicase in late S phase Prevention of DNA re-replication in eukaryotic cells Quaternary structure of the human Cdt1-Geminin complex regulates DNA replication licensing The Geminin and Idas Coiled Coils Preferentially Form a Heterodimer That Inhibits Geminin Function in DNA Replication Licensing HBO1 histone acetylase activity is essential for DNA replication licensing and inhibited by Geminin Aurora-A controls pre-replicative complex assembly and DNA replication by stabilizing geminin in mitosis.Chromatin unfolding by Cdt1 regulates MCM loading via opposing functions of HBO1 and HDAC11-geminin.Acetylation/deacetylation modulates the stability of DNA replication licensing factor Cdt1.Inter- and intrachromosomal asynchrony of cell division cycle events in root meristem cells of Allium cepa: possible connection with gradient of cyclin B-like proteins.The DNA unwinding element binding protein DUE-B interacts with Cdc45 in preinitiation complex formation.Replication licensing and the DNA damage checkpoint.Hoxa9 transduction induces hematopoietic stem and progenitor cell activity through direct down-regulation of geminin protein Knockdown of SCF(Skp2) function causes double-parked accumulation in the nucleus and DNA re-replication in Drosophila plasmatocytes.Geminin overexpression prevents the completion of topoisomerase IIα chromosome decatenation, leading to aneuploidy in human mammary epithelial cells Cell cycle adaptations of embryonic stem cells.An inactive geminin mutant that binds cdt1 Tipin is required for stalled replication forks to resume DNA replication after removal of aphidicolin in Xenopus egg extracts.Manipulation of Cell Cycle and Chromatin Configuration by Means of Cell-Penetrating Geminin Re-replication induced by geminin depletion occurs from G2 and is enhanced by checkpoint activation.Dynamic interactions of high Cdt1 and geminin levels regulate S phase in early Xenopus embryos.Scmh1 has E3 ubiquitin ligase activity for geminin and histone H2A and regulates geminin stability directly or indirectly via transcriptional repression of Hoxa9 and Hoxb4 Geminin deletion in mouse oocytes results in impaired embryo development and reduced fertility Cell cycle regulation of DNA replication.Characterization of conserved arginine residues on Cdt1 that affect licensing activity and interaction with Geminin or Mcm complex.Geminin deploys multiple mechanisms to regulate Cdt1 before cell division thus ensuring the proper execution of DNA replication.Replication initiation complex formation in the absence of nuclear function in Xenopus.NF-kappaB and Snail1a coordinate the cell cycle with gastrulation Geminin stabilizes Cdt1 during meiosis in Xenopus oocytes.Regulation of DNA Replication in Early Embryonic Cleavages.Links between DNA Replication, Stem Cells and Cancer.PIP degron proteins, substrates of CRL4Cdt2, and not PIP boxes, interfere with DNA polymerase η and κ focus formation on UV damage Molecular mechanisms of DNA replication checkpoint activation Transcription of the Geminin gene is regulated by a negative-feedback loop.Flipping the switch from g1 to s phase with e3 ubiquitin ligases Role of Geminin in cell fate determination of hematopoietic stem cells (HSCs).Mechanisms and regulation of DNA replication initiation in eukaryotes.Nuclear DNA replication and repair in parasites of the genus Leishmania: Exploiting differences to develop innovative therapeutic approaches.Dynamic association of ORCA with prereplicative complex components regulates DNA replication initiation.Human CDT1 associates with CDC7 and recruits CDC45 to chromatin during S phase.

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P2860

A Cdt1-geminin complex licenses chromatin for DNA replication and prevents rereplication during S phase in Xenopus.

http://www.wikidata.org/entity/Q35222221

description

2006 nî lūn-bûn

@nan

2006 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

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2006 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2006年の論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年论文

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name

A Cdt1-geminin complex license ...... ion during S phase in Xenopus.

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A Cdt1-geminin complex license ...... ion during S phase in Xenopus.

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type

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A Cdt1-geminin complex license ...... ion during S phase in Xenopus.

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A Cdt1-geminin complex license ...... ion during S phase in Xenopus.

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A Cdt1-geminin complex license ...... ion during S phase in Xenopus.

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A Cdt1-geminin complex license ...... ion during S phase in Xenopus.

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SJ.EMBOJ.7601436

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The EMBO Journal

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A Cdt1-geminin complex license ...... ion during S phase in Xenopus.

@en

P2093

Domenico Maiorano

http://www.w3.org/2001/XMLSchema#string

Malik Lutzmann

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P2860

Inhibition of eukaryotic DNA replication by geminin binding to Cdt1

The regulated association of Cdt1 with minichromosome maintenance proteins and Cdc6 in mammalian cells

Two E3 ubiquitin ligases, SCF-Skp2 and DDB1-Cul4, target human Cdt1 for proteolysis.

Geminin, an inhibitor of DNA replication, is degraded during mitosis

Direct interaction of geminin and Six3 in eye development

Cdt1 phosphorylation by cyclin A-dependent kinases negatively regulates its function without affecting geminin binding

Geminin regulates neuronal differentiation by antagonizing Brg1 activity

Human geminin promotes pre-RC formation and DNA replication by stabilizing CDT1 in mitosis

Rereplication by depletion of geminin is seen regardless of p53 status and activates a G2/M checkpoint

Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint

P304

5764-5774

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scholarly article

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10.1038/SJ.EMBOJ.7601436

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24

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25

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Marcel Méchali

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2006-11-23T00:00:00Z

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6672726

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17124498

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1698883

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