Signal transduction by the high-affinity GM-CSF receptor: two distinct cytoplasmic regions of the common beta subunit responsible for different signaling
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Mouse oncostatin M: an immediate early gene induced by multiple cytokines through the JAK-STAT5 pathwayA novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptorsA critical cytoplasmic domain of the interleukin-5 (IL-5) receptor alpha chain and its function in IL-5-mediated growth signal transductionJAK2 associates with the beta c chain of the receptor for granulocyte-macrophage colony-stimulating factor, and its activation requires the membrane-proximal regionHuman interleukin-3 (IL-3) induces disulfide-linked IL-3 receptor alpha- and beta-chain heterodimerization, which is required for receptor activation but not high-affinity bindingFunctional regions of the mouse interleukin-10 receptor cytoplasmic domainSolution structure of the Shc SH2 domain complexed with a tyrosine-phosphorylated peptide from the T-cell receptorActivating point mutations in the common beta subunit of the human GM-CSF, IL-3 and IL-5 receptors suggest the involvement of beta subunit dimerization and cell type-specific molecules in signallingA dual-color fluorescence-based platform to identify selective inhibitors of Akt signalingDUB-1, a deubiquitinating enzyme with growth-suppressing activityA novel pathway from phosphorylation of tyrosine residues 239/240 of Shc, contributing to suppress apoptosis by IL-3Neutrophil cell surface receptors and their intracellular signal transduction pathways.Evidence for a requirement for both phospholipid and phosphotyrosine binding via the Shc phosphotyrosine-binding domain in vivoStoichiometric structure-function analysis of the prolactin receptor signaling domain by receptor chimeras.mcl-1 is an immediate-early gene activated by the granulocyte-macrophage colony-stimulating factor (GM-CSF) signaling pathway and is one component of the GM-CSF viability response.Future therapeutic targets in rheumatoid arthritis?JAK2/STAT5/Bcl-xL signalling is essential for erythropoietin-mediated protection against apoptosis induced in PC12 cells by the amyloid β-peptide Aβ25-35.Identification of a viability domain in the granulocyte/macrophage colony-stimulating factor receptor beta-chain involving tyrosine-750Two distinct interleukin-3-mediated signal pathways, Ras-NFIL3 (E4BP4) and Bcl-xL, regulate the survival of murine pro-B lymphocytes.The antiapoptotic gene mcl-1 is up-regulated by the phosphatidylinositol 3-kinase/Akt signaling pathway through a transcription factor complex containing CREBCytokine receptor common beta chain as a potential activator of cytokine withdrawal-induced apoptosis.Coupling of osteopontin and its cell surface receptor CD44 to the cell survival response elicited by interleukin-3 or granulocyte-macrophage colony-stimulating factor.Dna damage-induced G(1) arrest in hematopoietic cells is overridden following phosphatidylinositol 3-kinase-dependent activation of cyclin-dependent kinase 2Distinct regions of c-Mpl cytoplasmic domain are coupled to the JAK-STAT signal transduction pathway and Shc phosphorylationActivation of Stat5 by interleukin 2 requires a carboxyl-terminal region of the interleukin 2 receptor beta chain but is not essential for the proliferative signal transmission.Hematopoietic cytokines.The intracellular signal transduction mechanism of interleukin 5 in eosinophils: the involvement of lyn tyrosine kinase and the Ras-Raf-1-MEK-microtubule-associated protein kinase pathwayInvolvement of p59fynT in interleukin-5 receptor signaling.Src homology 2 protein tyrosine phosphatase (SHPTP2)/Src homology 2 phosphatase 2 (SHP2) tyrosine phosphatase is a positive regulator of the interleukin 5 receptor signal transduction pathways leading to the prolongation of eosinophil survival.Lyn, Jak2, and Raf-1 kinases are critical for the antiapoptotic effect of interleukin 5, whereas only Raf-1 kinase is essential for eosinophil activation and degranulation.Structural and signaling requirements for BCR-ABL-mediated transformation and inhibition of apoptosis.The extracellular signal-regulated kinase pathway phosphorylates AML1, an acute myeloid leukemia gene product, and potentially regulates its transactivation ability.The murine DUB-1 gene is specifically induced by the betac subunit of interleukin-3 receptor.GM-CSF increases LPS-induced production of proinflammatory mediators via upregulation of TLR4 and CD14 in murine microglia.Interleukin 3-dependent survival by the Akt protein kinaseGranulocyte-macrophage colony-stimulating factor and interleukin-3 signaling pathways converge on the CREB-binding site in the human egr-1 promoter.Modulation of growth factor receptor function by isoform heterodimerizationDetailed analysis of the IL-5-IL-5R alpha interaction: characterization of crucial residues on the ligand and the receptor.Downregulation of Bim, a proapoptotic relative of Bcl-2, is a pivotal step in cytokine-initiated survival signaling in murine hematopoietic progenitorsDefinition of the role of tyrosine residues of the common beta subunit regulating multiple signaling pathways of granulocyte-macrophage colony-stimulating factor receptor
P2860
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P2860
Signal transduction by the high-affinity GM-CSF receptor: two distinct cytoplasmic regions of the common beta subunit responsible for different signaling
description
1993 nî lūn-bûn
@nan
1993 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1993 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
1993年の論文
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1993年学术文章
@wuu
1993年学术文章
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1993年学术文章
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1993年学术文章
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1993年学术文章
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1993年學術文章
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name
Signal transduction by the hig ...... nsible for different signaling
@ast
Signal transduction by the hig ...... nsible for different signaling
@en
Signal transduction by the hig ...... nsible for different signaling
@nl
type
label
Signal transduction by the hig ...... nsible for different signaling
@ast
Signal transduction by the hig ...... nsible for different signaling
@en
Signal transduction by the hig ...... nsible for different signaling
@nl
prefLabel
Signal transduction by the hig ...... nsible for different signaling
@ast
Signal transduction by the hig ...... nsible for different signaling
@en
Signal transduction by the hig ...... nsible for different signaling
@nl
P2093
P2860
P1433
P1476
Signal transduction by the hig ...... nsible for different signaling
@en
P2093
P2860
P304
P407
P577
1993-11-01T00:00:00Z