Identification of a viability domain in the granulocyte/macrophage colony-stimulating factor receptor beta-chain involving tyrosine-750
about
Evidence for a physical association between the Shc-PTB domain and the beta c chain of the granulocyte-macrophage colony-stimulating factor receptorSHP1 and SHP2 protein-tyrosine phosphatases associate with betac after interleukin-3-induced receptor tyrosine phosphorylation. Identification of potential binding sites and substratesEvidence for a requirement for both phospholipid and phosphotyrosine binding via the Shc phosphotyrosine-binding domain in vivoIL-3 signaling and the role of Src kinases, JAKs and STATs: a covert liaison unveiled.Intracellular signal transduction in eosinophils and its clinical significance.JAK/STAT, Raf/MEK/ERK, PI3K/Akt and BCR-ABL in cell cycle progression and leukemogenesis.Biochemical assessment of intracellular signal transduction pathways in eosinophils: implications for pharmacotherapy.Src homology 2 protein tyrosine phosphatase (SHPTP2)/Src homology 2 phosphatase 2 (SHP2) tyrosine phosphatase is a positive regulator of the interleukin 5 receptor signal transduction pathways leading to the prolongation of eosinophil survival.Lyn, Jak2, and Raf-1 kinases are critical for the antiapoptotic effect of interleukin 5, whereas only Raf-1 kinase is essential for eosinophil activation and degranulation.Alteration of Akt activity increases chemotherapeutic drug and hormonal resistance in breast cancer yet confers an achilles heel by sensitization to targeted therapy.Contributions of the Raf/MEK/ERK, PI3K/PTEN/Akt/mTOR and Jak/STAT pathways to leukemia.The signaling mechanism of eosinophil activation.Targeting the RAF/MEK/ERK, PI3K/AKT and p53 pathways in hematopoietic drug resistance.Role of the protein tyrosine phosphatase SHP-1 (Src homology phosphatase-1) in the regulation of interleukin-3-induced survival, proliferation and signalling.Dissection of the cytoplasmic domains of cytokine receptors involved in STAT and Ras dependent proliferation.Multiple tyrosine residues in the intracellular domain of the common beta subunit of the interleukin 5 receptor are involved in activation of STAT5.The kinase domain of Jak2 mediates induction of bcl-2 and delays cell death in hematopoietic cells.Lyn tyrosine kinase is essential for erythropoietin-induced differentiation of J2E erythroid cells.Tyrosine residues in the granulocyte colony-stimulating factor (G-CSF) receptor mediate G-CSF-induced differentiation of murine myeloid leukemic (M1) cells.
P2860
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P2860
Identification of a viability domain in the granulocyte/macrophage colony-stimulating factor receptor beta-chain involving tyrosine-750
description
1995 nî lūn-bûn
@nan
1995 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
name
Identification of a viability ...... a-chain involving tyrosine-750
@ast
Identification of a viability ...... a-chain involving tyrosine-750
@en
type
label
Identification of a viability ...... a-chain involving tyrosine-750
@ast
Identification of a viability ...... a-chain involving tyrosine-750
@en
prefLabel
Identification of a viability ...... a-chain involving tyrosine-750
@ast
Identification of a viability ...... a-chain involving tyrosine-750
@en
P2093
P2860
P356
P1476
Identification of a viability ...... a-chain involving tyrosine-750
@en
P2093
J D Griffin
N Carlesso
R C Inhorn
P2860
P304
P356
10.1073/PNAS.92.19.8665
P407
P577
1995-09-01T00:00:00Z