Structural basis of HIV-1 resistance to AZT by excision - Wikidata - wikimedia - TriplyDB

Structural basis of HIV-1 resistance to AZT by excision

Structural basis of HIV-1 resistance to AZT by excision

http://www.wikidata.org/entity/Q24596976

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K70Q adds high-level tenofovir resistance to "Q151M complex" HIV reverse transcriptase through the enhanced discrimination mechanism Current perspectives on HIV-1 antiretroviral drug resistance Common and unique features of viral RNA-dependent polymerases HIV-1 reverse transcription HIV-1 Reverse Transcriptase (RT) Polymorphism 172K Suppresses the Effect of Clinically Relevant Drug Resistance Mutations to Both Nucleoside and Non-nucleoside RT Inhibitors Complexes of HIV-1 RT, NNRTI and RNA/DNA hybrid reveal a structure compatible with RNA degradation Structural and Inhibition Studies of the RNase H Function of Xenotropic Murine Leukemia Virus-Related Virus Reverse Transcriptase HIV-1 reverse transcriptase complex with DNA and nevirapine reveals non-nucleoside inhibition mechanism Approved Antiviral Drugs over the Past 50 Years Mechanism of ganciclovir-induced chain termination revealed by resistant viral polymerase mutants with reduced exonuclease activity HIV-1 polymerase inhibition by nucleoside analogs: cellular- and kinetic parameters of efficacy, susceptibility and resistance selection Zidovudine (AZT) monotherapy selects for the A360V mutation in the connection domain of HIV-1 reverse transcriptase Molecular dynamics study of HIV-1 RT-DNA-nevirapine complexes explains NNRTI inhibition and resistance by connection mutations Prediction of HIV drug resistance from genotype with encoded three-dimensional protein structure Clicking 3'-azidothymidine into novel potent inhibitors of human immunodeficiency virus.Patterns of recombination in HIV-1M are influenced by selection disfavouring the survival of recombinants with disrupted genomic RNA and protein structures A cell-intrinsic inhibitor of HIV-1 reverse transcription in CD4(+) T cells from elite controllers Recent findings on the mechanisms involved in tenofovir resistance.HIV-1 reverse transcriptase and antiviral drug resistance. Part 2.4'-C-methyl-2'-deoxyadenosine and 4'-C-ethyl-2'-deoxyadenosine inhibit HIV-1 replication The base component of 3'-azido-2',3'-dideoxynucleosides influences resistance mutations selected in HIV-1 reverse transcriptase.Structures of reverse transcriptase pre- and post-excision complexes shed new light on HIV-1 AZT resistance Substrate mimicry: HIV-1 reverse transcriptase recognizes 6-modified-3'-azido-2',3'-dideoxyguanosine-5'-triphosphates as adenosine analogs.HIV-1 and HIV-2 reverse transcriptases: different mechanisms of resistance to nucleoside reverse transcriptase inhibitors.Role of induced fit in limiting discrimination against AZT by HIV reverse transcriptase Understanding the molecular mechanism of sequence dependent tenofovir removal by HIV-1 reverse transcriptase: differences in primer binding site versus polypurine tract Bioinformatic Identification of Rare Codon Clusters (RCCs) in HBV Genome and Evaluation of RCCs in Proteins Structure of Hepatitis B Virus.Analysis of the Zidovudine Resistance Mutations T215Y, M41L, and L210W in HIV-1 Reverse Transcriptase.NTP-mediated nucleotide excision activity of hepatitis C virus RNA-dependent RNA polymerase.The structural biology of HIV-1: mechanistic and therapeutic insights Formation of a quaternary complex of HIV-1 reverse transcriptase with a nucleotide-competing inhibitor and its ATP enhancer.Design, Synthesis, and Biological Evaluations of Hydroxypyridonecarboxylic Acids as Inhibitors of HIV Reverse Transcriptase Associated RNase H.Hypersusceptibility mechanism of Tenofovir-resistant HIV to EFdA.Conformational Plasticity of the NNRTI-Binding Pocket in HIV-1 Reverse Transcriptase: A Fluorine Nuclear Magnetic Resonance Study.Clinical significance of HIV reverse-transcriptase inhibitor-resistance mutations.The lysine 65 residue in HIV-1 reverse transcriptase function and in nucleoside analog drug resistance.Biochemical characterization of a multi-drug resistant HIV-1 subtype AG reverse transcriptase: antagonism of AZT discrimination and excision pathways and sensitivity to RNase H inhibitors.Structural Insights into HIV Reverse Transcriptase Mutations Q151M and Q151M Complex That Confer Multinucleoside Drug Resistance.Molecular basis and potential activity of HIV-1 reverse transcriptase toward trimethylamine-based compounds.Conformational States of HIV-1 Reverse Transcriptase for Nucleotide Incorporation vs Pyrophosphorolysis-Binding of Foscarnet.

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Structural basis of HIV-1 resistance to AZT by excision

http://www.wikidata.org/entity/Q24596976

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2010 nî lūn-bûn

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2010 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

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2010年論文

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2010年论文

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name

Structural basis of HIV-1 resistance to AZT by excision

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Structural basis of HIV-1 resistance to AZT by excision

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Structural basis of HIV-1 resistance to AZT by excision

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Structural basis of HIV-1 resistance to AZT by excision

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Structural basis of HIV-1 resistance to AZT by excision

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Structural basis of HIV-1 resistance to AZT by excision

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Structural basis of HIV-1 resistance to AZT by excision

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Structural basis of HIV-1 resistance to AZT by excision

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Structural basis of HIV-1 resistance to AZT by excision

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Nature Structural & Molecular Biology

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Structural basis of HIV-1 resistance to AZT by excision

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Arthur D Clark

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Barbara L Gaffney

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Joseph D Bauman

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Paul L Boyer

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Qianwei Han

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Roger A Jones

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Xiaorong Hou

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Xiongying Tu

http://www.w3.org/2001/XMLSchema#string

Yulia V Frenkel

http://www.w3.org/2001/XMLSchema#string

P2860

Selective excision of AZTMP by drug-resistant human immunodeficiency virus reverse transcriptase

Lamivudine (3TC) resistance in HIV-1 reverse transcriptase involves steric hindrance with beta-branched amino acids

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

Pyrophosphorolytic Excision of Nonobligate Chain Terminators by Hepatitis C Virus NS5B Polymerase

Structure of a soluble secreted chemokine inhibitor vCCI (p35) from cowpox virus

Structures of HIV-1 reverse transcriptase with pre- and post-translocation AZTMP-terminated DNA.

Structural Basis for the Role of the K65R Mutation in HIV-1 Reverse Transcriptase Polymerization, Excision Antagonism, and Tenofovir Resistance

Structure of unliganded HIV-1 reverse transcriptase at 2.7 A resolution: implications of conformational changes for polymerization and inhibition mechanisms

Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase: implications for drug resistance

Toward the structural genomics of complexes: Crystal structure of a PE/PPE protein complex from Mycobacterium tuberculosis

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1202-9

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3142597

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10.1038/NSMB.1908

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10

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17

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Stefan G. Sarafianos

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2010-10-01T00:00:00Z

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46306866

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1010007278

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20852643

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structural biology

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2987654

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