Allopregnanolone reverses neurogenic and cognitive deficits in mouse model of Alzheimer's disease - Wikidata - wikimedia - TriplyDB

Allopregnanolone reverses neurogenic and cognitive deficits in mouse model of Alzheimer's disease

Allopregnanolone reverses neurogenic and cognitive deficits in mouse model of Alzheimer's disease

http://www.wikidata.org/entity/Q24600153

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Neurosteroids and GABA(A) Receptor Interactions: A Focus on Stress Roles for oestrogen receptor β in adult brain function Neurotrophic factor small-molecule mimetics mediated neuroregeneration and synaptic repair: emerging therapeutic modality for Alzheimer's disease Advances in the Understanding of the Gabaergic Neurobiology of FMR1 Expanded Alleles Leading to Targeted Treatments for Fragile X Spectrum Disorder Current concept in neural regeneration research: NSCs isolation, characterization and transplantation in various neurodegenerative diseases and stroke: A review APP intracellular domain impairs adult neurogenesis in transgenic mice by inducing neuroinflammation Allopregnanolone reinstates tyrosine hydroxylase immunoreactive neurons and motor performance in an MPTP-lesioned mouse model of Parkinson's disease GABAA receptor-acting neurosteroids: a role in the development and regulation of the stress response Differential responses of progesterone receptor membrane component-1 (Pgrmc1) and the classical progesterone receptor (Pgr) to 17β-estradiol and progesterone in hippocampal subregions that support synaptic remodeling and neurogenesis Allopregnanolone promotes regeneration and reduces β-amyloid burden in a preclinical model of Alzheimer's disease Neurosteroids reduce social isolation-induced behavioral deficits: a proposed link with neurosteroid-mediated upregulation of BDNF expression.Fragile X-Associated Tremor/Ataxia Syndrome: From Molecular Pathogenesis to Development of Therapeutics.High throughput analysis of neural progenitor cell proliferation in adult rodent hippocampus.Allopregnanolone and neuroinflammation: a focus on multiple sclerosis.Fluoxetine attenuates the impairment of spatial learning ability and prevents neuron loss in middle-aged APPswe/PSEN1dE9 double transgenic Alzheimer's disease mice.Frontiers in therapeutic development of allopregnanolone for Alzheimer's disease and other neurological disorders.Allopregnanolone and neurogenesis in the nigrostriatal tract.Adipose-derived mesenchymal stem cell transplantation promotes adult neurogenesis in the brains of Alzheimer's disease mice.Palmitoylethanolamide stimulation induces allopregnanolone synthesis in C6 Cells and primary astrocytes: involvement of peroxisome-proliferator activated receptor-α.Neuroregeneration and dementia: new treatment options.Development of proneurogenic, neuroprotective small molecules.Progesterone and allopregnanolone improves stroke outcome in male mice via distinct mechanisms but neither promotes neurogenesis.Neurosteroid 3α-androstanediol efficiently counteracts paclitaxel-induced peripheral neuropathy and painful symptoms New approaches to treating Alzheimer's disease Endothelial p53 deletion improves angiogenesis and prevents cardiac fibrosis and heart failure induced by pressure overload in mice.Prenatal Stress Alters Progestogens to Mediate Susceptibility to Sex-Typical, Stress-Sensitive Disorders, such as Drug Abuse: A Review.Genetic manipulation of adult-born hippocampal neurons rescues memory in a mouse model of Alzheimer's disease.Allopregnanolone restores hippocampal-dependent learning and memory and neural progenitor survival in aging 3xTgAD and nonTg mice.FGF2 gene transfer restores hippocampal functions in mouse models of Alzheimer's disease and has therapeutic implications for neurocognitive disorders Up-regulation of neurosteroid biosynthesis as a pharmacological strategy to improve behavioural deficits in a putative mouse model of post-traumatic stress disorder Allopregnanolone preclinical acute pharmacokinetic and pharmacodynamic studies to predict tolerability and efficacy for Alzheimer's disease.Neuroprotective effects of 17β-estradiol rely on estrogen receptor membrane initiated signals.Allopregnanolone increases the number of dopaminergic neurons in substantia nigra of a triple transgenic mouse model of Alzheimer's disease.Neuroregenerative mechanisms of allopregnanolone in Alzheimer's disease.A herbal medicine for Alzheimer's disease and its active constituents promote neural progenitor proliferation.17β-estradiol and progesterone regulate expression of β-amyloid clearance factors in primary neuron cultures and female rat brain Age-related changes in neuroactive steroid levels in 3xTg-AD mice.Neurosteroidogenesis Today: Novel Targets for Neuroactive Steroid Synthesis and Action and Their Relevance for Translational Research.Neurosteroids, stress and depression: potential therapeutic opportunities.Mifepristone alters amyloid precursor protein processing to preclude amyloid beta and also reduces tau pathology.

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Allopregnanolone reverses neurogenic and cognitive deficits in mouse model of Alzheimer's disease

http://www.wikidata.org/entity/Q24600153

description

2010 nî lūn-bûn

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2010 թուականի Ապրիլին հրատարակուած գիտական յօդուած

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2010年の論文

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Allopregnanolone reverses neur ...... e model of Alzheimer's disease

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Allopregnanolone reverses neur ...... e model of Alzheimer's disease

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Allopregnanolone reverses neur ...... e model of Alzheimer's disease

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Allopregnanolone reverses neur ...... e model of Alzheimer's disease

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Eun Ji Chung

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Jun Ming Wang

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Lifei Liu

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Richard F Thompson

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Roberta Diaz Brinton

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Shuhua Chen

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Cell cycle regulation in the postmitotic neuron: oxymoron or new biology?

Neurons born in the adult dentate gyrus form functional synapses with target cells

Deficient neurogenesis in forebrain-specific presenilin-1 knockout mice is associated with reduced clearance of hippocampal memory traces

Neurosteroids: biochemistry and clinical significance

Multiple functions of type 10 17beta-hydroxysteroid dehydrogenase

The neurosteroid allopregnanolone promotes proliferation of rodent and human neural progenitor cells and regulates cell-cycle gene and protein expression

Progesterone receptors: form and function in brain

Neurogenesis in the dentate gyrus of the adult rat: age-related decrease of neuronal progenitor proliferation

Ontogeny of 5 alpha-reductase (type 1) messenger ribonucleic acid expression in rat brain: early presence in germinal zones

Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction

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Alzheimer's disease

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