Use of glucuronidation fingerprinting to describe and predict mono- and dihydroxyflavone metabolism by recombinant UGT isoforms and human intestinal and liver microsomes
about
The role of metabolism (and the microbiome) in defining the clinical efficacy of dietary flavonoidsBiotransformation of bisphenol AF to its major glucuronide metabolite reduces estrogenic activityBioavailability and pharmacokinetics of genistein: mechanistic studies on its ADME.Absolute quantification of UGT1A1 in various tissues and cell lines using isotope label-free UPLC-MS/MS method determines its turnover number and correlates with its glucuronidation activities.Sulfation of selected mono-hydroxyflavones by sulfotransferases in vitro: a species and gender comparison.Revolving door action of breast cancer resistance protein (BCRP) facilitates or controls the efflux of flavone glucuronides from UGT1A9-overexpressing HeLa cells.Mutual interactions between flavonoids and enzymatic and transporter elements responsible for flavonoid disposition via phase II metabolic pathways.Three-dimensional quantitative structure-activity relationship studies on UGT1A9-mediated 3-O-glucuronidation of natural flavonols using a pharmacophore-based comparative molecular field analysis model.UDP-glucuronosyltransferase (UGT) 1A9-overexpressing HeLa cells is an appropriate tool to delineate the kinetic interplay between breast cancer resistance protein (BRCP) and UGT and to rapidly identify the glucuronide substrates of BCRP.Analysis of the pharmacokinetics and metabolism of aloe-emodin following intravenous and oral administrations in rats.Evaluation of 3,3',4'-trihydroxyflavone and 3,6,4'-trihydroxyflavone (4'-O-glucuronidation) as the in vitro functional markers for hepatic UGT1A1.SULT1A3-mediated regiospecific 7-O-sulfation of flavonoids in Caco-2 cells can be explained by the relevant molecular docking studies.First-pass metabolism via UDP-glucuronosyltransferase: a barrier to oral bioavailability of phenolics.Systematic studies of sulfation and glucuronidation of 12 flavonoids in the mouse liver S9 fraction reveal both unique and shared positional preferences.Regioselective glucuronidation of flavonols by six human UGT1A isoforms.Regioselective sulfation and glucuronidation of phenolics: insights into the structural basis.Regiospecificity of human UDP-glucuronosyltransferase isoforms in chalcone and flavanone glucuronidation determined by metal complexation and tandem mass spectrometry.Mutual regioselective inhibition of human UGT1A1-mediated glucuronidation of four flavonoidsEstablishment and use of new MDCK II cells overexpressing both UGT1A1 and MRP2 to characterize flavonoid metabolism via the glucuronidation pathwayValidated LC-MS/MS method for the determination of 3-hydroxflavone and its glucuronide in blood and bioequivalent buffers: application to pharmacokinetic, absorption, and metabolism studies.UGT1A polymorphisms as genetic biomarkers for hepatocellular carcinoma risk in Caucasian population.Regioselective glucuronidation of gingerols by human liver microsomes and expressed UDP-glucuronosyltransferase enzymes: reaction kinetics and activity correlation analyses for UGT1A9 and UGT2B7.Uridine diphosphate glucuronosyltransferase isoform-dependent regiospecificity of glucuronidation of flavonoids.Species- and gender-dependent differences in the glucuronidation of a flavonoid glucoside and its aglycone determined using expressed UGT enzymes and microsomes.Simultaneous determination of tilianin and its metabolites in mice using ultra-high-performance liquid chromatography with tandem mass spectrometry and its application to a pharmacokinetic study.Breast Cancer Resistance Protein and Multidrug Resistance Protein 2 Regulate the Disposition of Acacetin Glucuronides.
P2860
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P2860
Use of glucuronidation fingerprinting to describe and predict mono- and dihydroxyflavone metabolism by recombinant UGT isoforms and human intestinal and liver microsomes
description
2010 nî lūn-bûn
@nan
2010 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Use of glucuronidation fingerp ...... ntestinal and liver microsomes
@ast
Use of glucuronidation fingerp ...... ntestinal and liver microsomes
@en
Use of glucuronidation fingerp ...... ntestinal and liver microsomes
@nl
type
label
Use of glucuronidation fingerp ...... ntestinal and liver microsomes
@ast
Use of glucuronidation fingerp ...... ntestinal and liver microsomes
@en
Use of glucuronidation fingerp ...... ntestinal and liver microsomes
@nl
prefLabel
Use of glucuronidation fingerp ...... ntestinal and liver microsomes
@ast
Use of glucuronidation fingerp ...... ntestinal and liver microsomes
@en
Use of glucuronidation fingerp ...... ntestinal and liver microsomes
@nl
P2093
P2860
P356
P1476
Use of glucuronidation fingerp ...... ntestinal and liver microsomes
@en
P2093
Baojian Wu
Rashim Singh
Zhongqiu Liu
P2860
P304
P356
10.1021/MP900223C
P407
P577
2010-06-07T00:00:00Z