Membrane position of ibuprofen agrees with suggested access path entrance to cytochrome P450 2C9 active site
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NSAIDs and Cardiovascular Diseases: Role of Reactive Oxygen SpeciesA novel type of allosteric regulation: functional cooperativity in monomeric proteinsPolymorphic cytochrome P450 enzymes (CYPs) and their role in personalized therapyStructural diversity of eukaryotic membrane cytochrome p450sThe Role of Protein-Protein and Protein-Membrane Interactions on P450 FunctionConformational Adaptation of Human Cytochrome P450 2B6 and Rabbit Cytochrome P450 2B4 Revealed upon Binding Multiple Amlodipine MoleculesCrystal Structure of Human Cytochrome P450 2D6 with Prinomastat BoundArchitecture of a single membrane spanning cytochrome P450 suggests constraints that orient the catalytic domain relative to a bilayerMOLE 2.0: advanced approach for analysis of biomacromolecular channelsThe role of cytochrome P450 2B6 and 2B4 substrate access channel residues predicted based on crystal structures of the amlodipine complexesHerbal medicines in Brazil: pharmacokinetic profile and potential herb-drug interactions.Dynamics of CYP51: implications for function and inhibitor design.Web resources for pharmacogenomics.Incorporation of charged residues in the CYP2J2 F-G loop disrupts CYP2J2-lipid bilayer interactions.MOLEonline 2.0: interactive web-based analysis of biomacromolecular channelsStructural characterization of human cholesterol 7α-hydroxylaseLigand tunnels in T. brucei and human CYP51: Insights for parasite-specific drug design.Cross-linking mass spectrometry and mutagenesis confirm the functional importance of surface interactions between CYP3A4 and holo/apo cytochrome b(5).Characterizing the membrane-bound state of cytochrome P450 3A4: structure, depth of insertion, and orientation.Association between the CYP11 family and six cancer types.Functional studies of N-terminally modified CYP2J2 epoxygenase in model lipid bilayersNADH:Cytochrome b5 Reductase and Cytochrome b5 Can Act as Sole Electron Donors to Human Cytochrome P450 1A1-Mediated Oxidation and DNA Adduct Formation by Benzo[a]pyrene.Molecular simulations of aromatase reveal new insights into the mechanism of ligand binding.Correlating structure and function of drug-metabolizing enzymes: progress and ongoing challenges.Catalytic Conversion of Lipophilic Substrates by Phase constrained Enzymes in the Aqueous or in the Membrane Phase.Membrane Fluidity Modulates Thermal Stability and Ligand Binding of Cytochrome P4503A4 in Lipid Nanodiscs.An update on the ability of St. John's wort to affect the metabolism of other drugs.Conformational diversity and ligand tunnels of mammalian cytochrome P450s.Potential herb-drug interaction in the prevention of cardiovascular diseases during integrated traditional and Western medicine treatment.Molecular dynamics investigations of membrane-bound CYP2C19 polymorphisms reveal distinct mechanisms for peripheral variants by long-range effects on the enzymatic activity.The catalytic function of cytochrome P450 is entwined with its membrane-bound nature.Recent advances in nanodisc technology for membrane protein studies (2012-2017).Cytochrome P450 structure-function: insights from molecular dynamics simulations.NADPH- and NADH-dependent metabolism of and DNA adduct formation by benzo[a]pyrene catalyzed with rat hepatic microsomes and cytochrome P450 1A1.Convergence of Free Energy Profile of Coumarin in Lipid Bilayer.Investigation of indazole unbinding pathways in CYP2E1 by molecular dynamics simulations.Nanodiscs in the studies of membrane-bound cytochrome P450 enzymes.Lipid molecules can induce an opening of membrane-facing tunnels in cytochrome P450 1A2.Structural Basis of Single-Nucleotide Polymorphisms in Cytochrome P450 2C9.Partitioning of caffeine in lipid bilayers reduces membrane fluidity and increases membrane thickness.
P2860
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P2860
Membrane position of ibuprofen agrees with suggested access path entrance to cytochrome P450 2C9 active site
description
2011 nî lūn-bûn
@nan
2011 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Membrane position of ibuprofen ...... ytochrome P450 2C9 active site
@ast
Membrane position of ibuprofen ...... ytochrome P450 2C9 active site
@en
Membrane position of ibuprofen ...... ytochrome P450 2C9 active site
@nl
type
label
Membrane position of ibuprofen ...... ytochrome P450 2C9 active site
@ast
Membrane position of ibuprofen ...... ytochrome P450 2C9 active site
@en
Membrane position of ibuprofen ...... ytochrome P450 2C9 active site
@nl
prefLabel
Membrane position of ibuprofen ...... ytochrome P450 2C9 active site
@ast
Membrane position of ibuprofen ...... ytochrome P450 2C9 active site
@en
Membrane position of ibuprofen ...... ytochrome P450 2C9 active site
@nl
P2860
P50
P3181
P356
P1476
Membrane position of ibuprofen ...... ytochrome P450 2C9 active site
@en
P2093
Tereza Hendrychová
P2860
P304
P3181
P356
10.1021/JP204488J
P407
P577
2011-10-20T00:00:00Z