Mammalian microsomal cytochrome P450 monooxygenase: structural adaptations for membrane binding and functional diversity
about
Cytochromes P450: a success storyAdaptations for the oxidation of polycyclic aromatic hydrocarbons exhibited by the structure of human P450 1A2Crystal structure of human cytochrome P450 2D6Structural basis for pregnenolone biosynthesis by the mitochondrial monooxygenase systemStructural insights into aldosterone synthase substrate specificity and targeted inhibitionStructural characterization of the complex between alpha-naphthoflavone and human cytochrome P450 1B1The human steroid hydroxylases CYP1B1 and CYP11B2Membrane position of ibuprofen agrees with suggested access path entrance to cytochrome P450 2C9 active siteKinetic and molecular analysis of 5-epiaristolochene 1,3-dihydroxylase, a cytochrome P450 enzyme catalyzing successive hydroxylations of sesquiterpenesCrystal structures of Trypanosoma brucei sterol 14alpha-demethylase and implications for selective treatment of human infectionsThe discovery of new coding alleles of human CYP26A1 that are potentially defective in the metabolism of all-trans retinoic acid and their assessment in a recombinant cDNA expression systemThe planetary biology of cytochrome P450 aromatasesStructural diversity of eukaryotic membrane cytochrome p450sCrystal structure of cytochrome P450 14 -sterol demethylase (CYP51) from Mycobacterium tuberculosis in complex with azole inhibitorsProbing the open state of cytochrome P450cam with ruthenium-linker substratesAtomic structure of Mycobacterium tuberculosis CYP121 to 1.06 A reveals novel features of cytochrome P450Substrate recognition and molecular mechanism of fatty acid hydroxylation by cytochrome P450 from Bacillus subtilis. Crystallographic, spectroscopic, and mutational studiesCrystal structure of human cytochrome P450 2C9 with bound warfarinCrystal structures of epothilone D-bound, epothilone B-bound, and substrate-free forms of cytochrome P450epoKAn open conformation of mammalian cytochrome P450 2B4 at 1.6-A resolutionStructure of human microsomal cytochrome P450 2C8. Evidence for a peripheral fatty acid binding siteStructural insight into the altered substrate specificity of human cytochrome P450 2A6 mutantsModes of heme binding and substrate access for cytochrome P450 CYP74A revealed by crystal structures of allene oxide synthaseCrystal Structures of Cytochrome P450 2B4 in Complex with the Inhibitor 1-Biphenyl-4-methyl-1 H -imidazole: Ligand-Induced Structural Response through α-Helical Repositioning ,Mutations of key hydrophobic surface residues of 11β-hydroxysteroid dehydrogenase type 1 increase solubility and monodispersity in a bacterial expression systemCrystal Structure of CYP24A1, a Mitochondrial Cytochrome P450 Involved in Vitamin D MetabolismPlasticity of Cytochrome P450 2B4 as Investigated by Hydrogen-Deuterium Exchange Mass Spectrometry and X-ray CrystallographyCrystal Structure of H2O2-dependent Cytochrome P450SP with Its Bound Fatty Acid Substrate: INSIGHT INTO THE REGIOSELECTIVE HYDROXYLATION OF FATTY ACIDS AT THE POSITIONStructures of Cytochrome P450 2B6 Bound to 4-Benzylpyridine and 4-(4-Nitrobenzyl)pyridine: Insight into Inhibitor Binding and Rearrangement of Active Site Side ChainsArchitecture of a single membrane spanning cytochrome P450 suggests constraints that orient the catalytic domain relative to a bilayerIsoniazid metabolism and hepatotoxicityIdentification of Tazarotenic Acid as the First Xenobiotic Substrate of Human Retinoic Acid Hydroxylase CYP26A1 and CYP26B1Recalling P446. P4501A1 (CYP1A1) opting for clinical applicationStructural insights into the function of steroidogenic cytochrome P450 17A1Variations on a (t)heme--novel mechanisms, redox partners and catalytic functions in the cytochrome P450 superfamilyInfluence of phenylalanine-481 substitutions on the catalytic activity of cytochrome P450 2D6Structure and dynamics of the membrane-bound cytochrome P450 2C9Identifying cytochrome p450 functional networks and their allosteric regulatory elementsSpecies differences in coumarin metabolism: a molecular modelling evaluation of CYP2A interactionsEvolutionarily divergent electron donor proteins interact with P450MT2 through the same helical domain but different contact points
P2860
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P2860
Mammalian microsomal cytochrome P450 monooxygenase: structural adaptations for membrane binding and functional diversity
description
2000 nî lūn-bûn
@nan
2000 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Mammalian microsomal cytochrom ...... nding and functional diversity
@ast
Mammalian microsomal cytochrom ...... nding and functional diversity
@en
Mammalian microsomal cytochrom ...... nding and functional diversity
@nl
type
label
Mammalian microsomal cytochrom ...... nding and functional diversity
@ast
Mammalian microsomal cytochrom ...... nding and functional diversity
@en
Mammalian microsomal cytochrom ...... nding and functional diversity
@nl
prefLabel
Mammalian microsomal cytochrom ...... nding and functional diversity
@ast
Mammalian microsomal cytochrom ...... nding and functional diversity
@en
Mammalian microsomal cytochrom ...... nding and functional diversity
@nl
P2093
P3181
P1433
P1476
Mammalian microsomal cytochrom ...... nding and functional diversity
@en
P2093
P304
P3181
P356
10.1016/S1097-2765(00)80408-6
P577
2000-01-01T00:00:00Z