Structures of YAP protein domains reveal promising targets for development of new cancer drugs
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Mst1 and Mst2 kinases: regulations and diseasesRegulation of TAZ in cancerEmerging role of Hippo pathway in gastric and other gastrointestinal cancersStructural Basis for Autoactivation of Human Mst2 Kinase and Its Regulation by RASSF5Targeting the Hippo Signaling Pathway for Tissue Regeneration and Cancer TherapyDLG5 in cell polarity maintenance and cancer developmentInhibition of neural crest formation by Kctd15 involves regulation of transcription factor AP-2Fluid shear stress activates YAP1 to promote cancer cell motilityCrystal structure of TAZ-TEAD complex reveals a distinct interaction mode from that of YAP-TEAD complex.Hippo-independent activation of YAP by the GNAQ uveal melanoma oncogene through a trio-regulated rho GTPase signaling circuitry.Downstream of mutant KRAS, the transcription regulator YAP is essential for neoplastic progression to pancreatic ductal adenocarcinomaStructural basis for Mob1-dependent activation of the core Mst-Lats kinase cascade in Hippo signalingInvolvement of the Hippo pathway in regeneration and fibrogenesis after ischaemic acute kidney injury: YAP is the key effectorPML Surfs into HIPPO Tumor Suppressor Pathway.Emerging roles of TEAD transcription factors and its coactivators in cancersPhosphorylation of Tyr188 in the WW domain of YAP1 plays an essential role in YAP1-induced cellular transformationThe Ets transcription factor GABP is a component of the hippo pathway essential for growth and antioxidant defense.Splice variant insertions in the C-terminus impairs YAP's transactivation domain.Regulation of the Hippo pathway and implications for anticancer drug development.Pro-invasive activity of the Hippo pathway effectors YAP and TAZ in cutaneous melanoma.Dual function of Yap in the regulation of lens progenitor cells and cellular polarity.Molecular basis of the binding of YAP transcriptional regulator to the ErbB4 receptor tyrosine kinase.Structural dissection of Hippo signaling.G protein-coupled receptors: bridging the gap from the extracellular signals to the Hippo pathway.GEP oncogene promotes cell proliferation through YAP activation in ovarian cancer.YAP1 Regulates OCT4 Activity and SOX2 Expression to Facilitate Self-Renewal and Vascular Mimicry of Stem-Like Cells.Prognostic significance of microRNA-141 expression and its tumor suppressor function in human pancreatic ductal adenocarcinoma.MicroRNA-186 targets Yes-associated protein 1 to inhibit Hippo signaling and tumorigenesis in hepatocellular carcinoma.Podocyte-Specific Deletion of Yes-Associated Protein Causes FSGS and Progressive Renal Failure.Integration of Hippo signalling and the unfolded protein response to restrain liver overgrowth and tumorigenesis.β-catenin-mediated YAP signaling promotes human glioma growth.Polyomavirus small T antigen interacts with yes-associated protein to regulate cell survival and differentiation.Yes-associated protein and immunosuppressive microenvironment in pancreatic cancer development: a new strategy to improve immunotherapy efficacy?MDCK cells expressing constitutively active Yes-associated protein (YAP) undergo apical extrusion depending on neighboring cell status.Dual roles of yes-associated protein (YAP) in colorectal cancer.The TEAD4-YAP/TAZ protein-protein interaction: expected similarities and unexpected differences.cAMP response element-binding protein and Yes-associated protein form a feedback loop that promotes neurite outgrowth.The Hippo pathway regulator KIBRA promotes podocyte injury by inhibiting YAP signaling and disrupting actin cytoskeletal dynamics.Cysteine residues are essential for dimerization of Hippo pathway components YAP2L and TAZ.PRDM4 mediates YAP-induced cell invasion by activating leukocyte-specific integrin β2 expression.
P2860
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P2860
Structures of YAP protein domains reveal promising targets for development of new cancer drugs
description
2012 nî lūn-bûn
@nan
2012 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Structures of YAP protein doma ...... evelopment of new cancer drugs
@ast
Structures of YAP protein doma ...... evelopment of new cancer drugs
@en
Structures of YAP protein doma ...... evelopment of new cancer drugs
@nl
type
label
Structures of YAP protein doma ...... evelopment of new cancer drugs
@ast
Structures of YAP protein doma ...... evelopment of new cancer drugs
@en
Structures of YAP protein doma ...... evelopment of new cancer drugs
@nl
prefLabel
Structures of YAP protein doma ...... evelopment of new cancer drugs
@ast
Structures of YAP protein doma ...... evelopment of new cancer drugs
@en
Structures of YAP protein doma ...... evelopment of new cancer drugs
@nl
P2093
P2860
P3181
P1476
Structures of YAP protein doma ...... evelopment of new cancer drugs
@en
P2093
Amjad Farooq
Denis C Shields
Marius Sudol
P2860
P304
P3181
P356
10.1016/J.SEMCDB.2012.05.002
P407
P577
2012-09-01T00:00:00Z