Hippo-independent activation of YAP by the GNAQ uveal melanoma oncogene through a trio-regulated rho GTPase signaling circuitry.
about
Regulation of TAZ in cancerG Protein-Coupled Receptors in CancerUveal melanoma as a target for immune-therapyMechanisms of Hippo pathway regulationEmerging role of Hippo pathway in gastric and other gastrointestinal cancersUpcoming translational challenges for uveal melanomaCurrent State of Animal (Mouse) Modeling in Melanoma ResearchMST kinases in development and diseaseTargeting the Hippo Signaling Pathway for Tissue Regeneration and Cancer TherapyYAP and TAZ: a nexus for Hippo signaling and beyondARF6 Is an Actionable Node that Orchestrates Oncogenic GNAQ Signaling in Uveal MelanomaHippo Pathway in Organ Size Control, Tissue Homeostasis, and CancerMultiparametric Analysis of Cell Shape Demonstrates that β-PIX Directly Couples YAP Activation to Extracellular Matrix AdhesionUveal melanoma: epidemiology, etiology, and treatment of primary disease.Uveal melanoma: From diagnosis to treatment and the science in between.Study design and rationale for a randomised, placebo-controlled, double-blind study to assess the efficacy of selumetinib (AZD6244; ARRY-142886) in combination with dacarbazine in patients with metastatic uveal melanoma (SUMIT).A reciprocal regulatory loop between TAZ/YAP and G-protein Gαs regulates Schwann cell proliferation and myelination.ZEB1 Regulates Multiple Oncogenic Components Involved in Uveal Melanoma Progression.The antihelminthic drug niclosamide effectively inhibits the malignant phenotypes of uveal melanoma in vitro and in vivo.Systematic genomic and translational efficiency studies of uveal melanoma.Oncotargeting G proteins: The Hippo in the room.Biology of advanced uveal melanoma and next steps for clinical therapeutics.Competing to coordinate cell fate decisions: the MST2-Raf-1 signaling deviceFGF8 promotes colorectal cancer growth and metastasis by activating YAP1.Disease implications of the Hippo/YAP pathway.Netrin-1 exerts oncogenic activities through enhancing Yes-associated protein stability.G Protein-Coupled Receptor and RhoA-Stimulated Transcriptional Responses: Links to Inflammation, Differentiation, and Cell Proliferation.Actin remodeling confers BRAF inhibitor resistance to melanoma cells through YAP/TAZ activation.A miR-130a-YAP positive feedback loop promotes organ size and tumorigenesis.The emerging roles of YAP and TAZ in cancerRAC-LATS1/2 signaling regulates YAP activity by switching between the YAP-binding partners TEAD4 and RUNX3.The Hippo/YAP pathway interacts with EGFR signaling and HPV oncoproteins to regulate cervical cancer progression.Neuregulin 1-activated ERBB4 interacts with YAP to induce Hippo pathway target genes and promote cell migration.Epidermal loss of Gαq confers a migratory and differentiation defect in keratinocytesThe Hippo pathway effectors YAP and TAZ promote cell growth by modulating amino acid signaling to mTORC1.YAP activation protects urothelial cell carcinoma from treatment-induced DNA damage.Myocardin-Related Transcription Factor A and Yes-Associated Protein Exert Dual Control in G Protein-Coupled Receptor- and RhoA-Mediated Transcriptional Regulation and Cell Proliferation.Kaposi sarcoma-associated herpesvirus promotes tumorigenesis by modulating the Hippo pathway.Targeted massively parallel sequencing of angiosarcomas reveals frequent activation of the mitogen activated protein kinase pathwayClass III-specific HDAC inhibitor Tenovin-6 induces apoptosis, suppresses migration and eliminates cancer stem cells in uveal melanoma
P2860
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P2860
Hippo-independent activation of YAP by the GNAQ uveal melanoma oncogene through a trio-regulated rho GTPase signaling circuitry.
description
2014 nî lūn-bûn
@nan
2014 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
Hippo-independent activation o ...... ho GTPase signaling circuitry.
@ast
Hippo-independent activation o ...... ho GTPase signaling circuitry.
@en
type
label
Hippo-independent activation o ...... ho GTPase signaling circuitry.
@ast
Hippo-independent activation o ...... ho GTPase signaling circuitry.
@en
prefLabel
Hippo-independent activation o ...... ho GTPase signaling circuitry.
@ast
Hippo-independent activation o ...... ho GTPase signaling circuitry.
@en
P2093
P2860
P50
P1433
P1476
Hippo-independent activation o ...... rho GTPase signaling circuitry
@en
P2093
Akrit Sodhi
Alfredo A Molinolo
Bruce R Ksander
Glenn Merlino
Maria Sol Degese
Qianming Chen
Xiaodong Feng
P2860
P304
P356
10.1016/J.CCR.2014.04.016
P577
2014-05-29T00:00:00Z