Structural basis for human NADPH-cytochrome P450 oxidoreductase deficiency - Wikidata - wikimedia - TriplyDB

Structural basis for human NADPH-cytochrome P450 oxidoreductase deficiency

Structural basis for human NADPH-cytochrome P450 oxidoreductase deficiency

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Pharmacogenomics of human P450 oxidoreductase Shedding light on protein folding, structural and functional dynamics by single molecule studies Molecular view of an electron transfer process essential for iron-sulfur protein biogenesis Cytochrome P450 17A1 Interactions with the FMN Domain of Its Reductase as Characterized by NMR NADPH-cytochrome P450 oxidoreductase: prototypic member of the diflavin reductase family.Probing the transmembrane structure and dynamics of microsomal NADPH-cytochrome P450 oxidoreductase by solid-state NMR.Research Resource: Correlating Human Cytochrome P450 21A2 Crystal Structure and Phenotypes of Mutations in Congenital Adrenal Hyperplasia.Distinct conformational behaviors of four mammalian dual-flavin reductases (cytochrome P450 reductase, methionine synthase reductase, neuronal nitric oxide synthase, endothelial nitric oxide synthase) determine their unique catalytic profiles.Identification of six novel P450 oxidoreductase missense variants in Ashkenazi and Moroccan Jewish populations.NADPH-cytochrome P450 reductase is regulated by all-trans retinoic acid and by 1,25-dihydroxyvitamin D3 in human acute myeloid leukemia cells.Real-time analysis of conformational control in electron transfer reactions of human cytochrome P450 reductase with cytochrome c Altered human CYP3A4 activity caused by Antley-Bixler syndrome-related variants of NADPH-cytochrome P450 oxidoreductase measured in a robust in vitro system Molecular Cloning, Expression Pattern and Polymorphisms of NADPH-Cytochrome P450 Reductase in the Bird Cherry-Oat Aphid Rhopalosiphum padi (L.).Genetic variations in NADPH-CYP450 oxidoreductase in a Czech Slavic cohort.NADPH-cytochrome P450 oxidoreductase: roles in physiology, pharmacology, and toxicology.Human cytochromes P450 in health and disease Unusual properties of the cytochrome P450 superfamily.Substrate-modulated cytochrome P450 17A1 and cytochrome b5 interactions revealed by NMR.Mapping of the Allosteric Site in Cholesterol Hydroxylase CYP46A1 for Efavirenz, a Drug That Stimulates Enzyme Activity Mutants of Cytochrome P450 Reductase Lacking Either Gly-141 or Gly-143 Destabilize Its FMN Semiquinone Phosphorylation of human cytochrome P450c17 by p38α selectively increases 17,20 lyase activity and androgen biosynthesis.Intra- and inter-molecular effects of a conserved arginine residue of neuronal and inducible nitric oxide synthases on FMN and calmodulin binding.Correlating structure and function of drug-metabolizing enzymes: progress and ongoing challenges.From cholesterogenesis to steroidogenesis: role of riboflavin and flavoenzymes in the biosynthesis of vitamin D.Kinetic and spectroscopic probes of motions and catalysis in the cytochrome P450 reductase family of enzymes.Formation of P450 · P450 complexes and their effect on P450 function Dynamic control of electron transfers in diflavin reductases.Orchestrated Domain Movement in Catalysis by Cytochrome P450 Reductase.Instability of the Human Cytochrome P450 Reductase A287P Variant Is the Major Contributor to Its Antley-Bixler Syndrome-like Phenotype.Structure of the Arabidopsis thaliana NADPH-cytochrome P450 reductase 2 (ATR2) provides insight into its function.Modeling of Anopheles minimus Mosquito NADPH-cytochrome P450 oxidoreductase (CYPOR) and mutagenesis analysis.A well-balanced preexisting equilibrium governs electron flux efficiency of a multidomain diflavin reductase.Redox-linked domain movements in the catalytic cycle of cytochrome p450 reductase.Molecular dynamics simulations give insight into the conformational change, complex formation, and electron transfer pathway for cytochrome P450 reductase.Electron transfer by human wild-type and A287P mutant P450 oxidoreductase assessed by transient kinetics: functional basis of P450 oxidoreductase deficiency.Functioning of Microsomal Cytochrome P450s: Murburn Concept Explains the Metabolism of Xenobiotics in Hepatocytes.Coexpression of CPR from various origins enhances biotransformation activity of human CYPs in S. pombe.Kinetic analysis of cytochrome P450 reductase from Artemisia annua reveals accelerated rates of NADH-dependent flavin reduction.The Hinge Segment of Human NADPH-Cytochrome P450 Reductase in Conformational Switching: The Critical Role of Ionic Strength.Structural and Kinetic Studies of Asp632 Mutants and Fully Reduced NADPH-Cytochrome P450 Oxidoreductase Define the Role of Asp632 Loop Dynamics in the Control of NADPH Binding and Hydride Transfer.

P2860

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P2860

Structural basis for human NADPH-cytochrome P450 oxidoreductase deficiency

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2011 nî lūn-bûn

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2011 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

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2011 թվականի օգոստոսին հրատարակված գիտական հոդված

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Structural basis for human NADPH-cytochrome P450 oxidoreductase deficiency

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Structural basis for human NADPH-cytochrome P450 oxidoreductase deficiency

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Structural basis for human NADPH-cytochrome P450 oxidoreductase deficiency

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Structural basis for human NADPH-cytochrome P450 oxidoreductase deficiency

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Structural basis for human NADPH-cytochrome P450 oxidoreductase deficiency

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Structural basis for human NADPH-cytochrome P450 oxidoreductase deficiency

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Structural basis for human NADPH-cytochrome P450 oxidoreductase deficiency

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Structural basis for human NADPH-cytochrome P450 oxidoreductase deficiency

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Structural basis for human NADPH-cytochrome P450 oxidoreductase deficiency

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Proceedings of the National Academy of Sciences of the United States of America

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Structural basis for human NADPH-cytochrome P450 oxidoreductase deficiency

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Bettie Sue Masters

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Christopher C Marohnic

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Chuanwu Xia

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Jung-Ja P Kim

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Satya P Panda

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P2860

Diversity and function of mutations in p450 oxidoreductase in patients with Antley-Bixler syndrome and disordered steroidogenesis

The molecular biology, biochemistry, and physiology of human steroidogenesis and its disorders

Three-dimensional structure of NADPH-cytochrome P450 reductase: prototype for FMN- and FAD-containing enzymes

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

Processing of X-ray diffraction data collected in oscillation mode

NADPH-cytochrome P450 oxidoreductase. Structural basis for hydride and electron transfer

Structure and Function of an NADPH-Cytochrome P450 Oxidoreductase in an Open Conformation Capable of Reducing Cytochrome P450

Conformational Changes of NADPH-Cytochrome P450 Oxidoreductase Are Essential for Catalysis and Cofactor Binding

The CCP4 suite: programs for protein crystallography

Association of multiple developmental defects and embryonic lethality with loss of microsomal NADPH-cytochrome P450 oxidoreductase

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cytochrome P450 Oxidoreductase Deficiency

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