Functional dissociation between PIKfyve-synthesized PtdIns5P and PtdIns(3,5)P2 by means of the PIKfyve inhibitor YM201636
about
PI(5)P regulates autophagosome biogenesisIn vivo, Pikfyve generates PI(3,5)P2, which serves as both a signaling lipid and the major precursor for PI5P.Phosphatidylinositol 3,5-bisphosphate: low abundance, high significanceInositol lipids: from an archaeal origin to phosphatidylinositol 3,5-bisphosphate faults in human diseasePhosphoinositides: tiny lipids with giant impact on cell regulationInhibition of PIKfyve by YM-201636 dysregulates autophagy and leads to apoptosis-independent neuronal cell deathSeptin 9 induces lipid droplets growth by a phosphatidylinositol-5-phosphate and microtubule-dependent mechanism hijacked by HCVMuscle-specific Pikfyve gene disruption causes glucose intolerance, insulin resistance, adiposity, and hyperinsulinemia but not muscle fiber-type switchingHost PI(3,5)P2 activity is required for Plasmodium berghei growth during liver stage infection.GLUT4 traffic through an ESCRT-III-dependent sorting compartment in adipocytes.Activity-dependent PI(3,5)P2 synthesis controls AMPA receptor trafficking during synaptic depression.Exploring phosphatidylinositol 5-phosphate 4-kinase function.Polyphosphoinositide binding domains: Key to inositol lipid biology.Detection and manipulation of phosphoinositides.Class III PI 3-kinase is the main source of PtdIns3P substrate and membrane recruitment signal for PIKfyve constitutive function in podocyte endomembrane homeostasisPtdIns5P: news and views of its appearance, disappearance and deeds.Toll-like receptor 9 trafficking and signaling for type I interferons requires PIKfyve activityModulation of synaptic function by VAC14, a protein that regulates the phosphoinositides PI(3,5)P₂ and PI(5)PPlentiful PtdIns5P from scanty PtdIns(3,5)P2 or from ample PtdIns? PIKfyve-dependent models: Evidence and speculation (response to: DOI 10.1002/bies.201300012).An Emerging Role for PI5P in T Cell Biology.The PIKfyve-ArPIKfyve-Sac3 triad in human breast cancer: Functional link between elevated Sac3 phosphatase and enhanced proliferation of triple negative cell lines.Phosphatidylinositol 5-phosphate: a nuclear stress lipid and a tuner of membranes and cytoskeleton dynamics.Active vacuolar H+ ATPase and functional cycle of Rab5 are required for the vacuolation defect triggered by PtdIns(3,5)P2 loss under PIKfyve or Vps34 deficiency.PIKfyve inhibition interferes with phagosome and endosome maturation in macrophages.PIKfyve, MTMR3 and their product PtdIns5P regulate cancer cell migration and invasion through activation of Rac1.The Lipid Kinase PIKfyve Coordinates the Neutrophil Immune Response through the Activation of the Rac GTPase.Inhibition of PIP4Kγ ameliorates the pathological effects of mutant huntingtin protein.Radiolabeling and Quantification of Cellular Levels of Phosphoinositides by High Performance Liquid Chromatography-coupled Flow Scintillation.Lysosome enlargement during inhibition of the lipid kinase PIKfyve proceeds through lysosome coalescence.Phosphatidylinositol 5-phosphate regulates invasion through binding and activation of Tiam1.Apilimod, a candidate anticancer therapeutic, arrests not only PtdIns(3,5)P2 but also PtdIns5P synthesis by PIKfyve and induces bafilomycin A1-reversible aberrant endomembrane dilation
P2860
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P2860
Functional dissociation between PIKfyve-synthesized PtdIns5P and PtdIns(3,5)P2 by means of the PIKfyve inhibitor YM201636
description
2012 nî lūn-bûn
@nan
2012 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Functional dissociation betwee ...... the PIKfyve inhibitor YM201636
@ast
Functional dissociation betwee ...... the PIKfyve inhibitor YM201636
@en
Functional dissociation betwee ...... the PIKfyve inhibitor YM201636
@nl
type
label
Functional dissociation betwee ...... the PIKfyve inhibitor YM201636
@ast
Functional dissociation betwee ...... the PIKfyve inhibitor YM201636
@en
Functional dissociation betwee ...... the PIKfyve inhibitor YM201636
@nl
prefLabel
Functional dissociation betwee ...... the PIKfyve inhibitor YM201636
@ast
Functional dissociation betwee ...... the PIKfyve inhibitor YM201636
@en
Functional dissociation betwee ...... the PIKfyve inhibitor YM201636
@nl
P2093
P2860
P3181
P1476
Functional dissociation betwee ...... the PIKfyve inhibitor YM201636
@en
P2093
Catherine Filios
Diego Sbrissa
Khortnal Delvecchio
Ognian C Ikonomov
P2860
P304
P3181
P356
10.1152/AJPCELL.00105.2012
P407
P577
2012-08-15T00:00:00Z