Active vacuolar H+ ATPase and functional cycle of Rab5 are required for the vacuolation defect triggered by PtdIns(3,5)P2 loss under PIKfyve or Vps34 deficiency.
about
Direct interaction of the Golgi V-ATPase a-subunit isoform with PI(4)P drives localization of Golgi V-ATPases in yeast.Identification of apilimod as a first-in-class PIKfyve kinase inhibitor for treatment of B-cell non-Hodgkin lymphoma.pH homeostasis links the nutrient sensing PKA/TORC1/Sch9 ménage-à-trois to stress tolerance and longevity.New pieces in the complex puzzle of aberrant vacuolation. Focus on "Active vacuolar H+ ATPase and functional cycle of Rab5 are required for the vacuolation defect triggered by PtdIns(3,5)P2 loss under PIKfyve or Vps34 deficiency".PI(3,5)P controls vacuole potassium transport to support cellular osmoregulationApilimod, a candidate anticancer therapeutic, arrests not only PtdIns(3,5)P2 but also PtdIns5P synthesis by PIKfyve and induces bafilomycin A1-reversible aberrant endomembrane dilation
P2860
Active vacuolar H+ ATPase and functional cycle of Rab5 are required for the vacuolation defect triggered by PtdIns(3,5)P2 loss under PIKfyve or Vps34 deficiency.
description
2016 nî lūn-bûn
@nan
2016年の論文
@ja
2016年論文
@yue
2016年論文
@zh-hant
2016年論文
@zh-hk
2016年論文
@zh-mo
2016年論文
@zh-tw
2016年论文
@wuu
2016年论文
@zh
2016年论文
@zh-cn
name
Active vacuolar H+ ATPase and ...... r PIKfyve or Vps34 deficiency.
@en
type
label
Active vacuolar H+ ATPase and ...... r PIKfyve or Vps34 deficiency.
@en
prefLabel
Active vacuolar H+ ATPase and ...... r PIKfyve or Vps34 deficiency.
@en
P2093
P2860
P1476
Active vacuolar H+ ATPase and ...... r PIKfyve or Vps34 deficiency.
@en
P2093
Assia Shisheva
Diego Sbrissa
Lauren M Compton
Ognian C Ikonomov
Puneet Garg
P2860
P304
P356
10.1152/AJPCELL.00104.2016
P577
2016-06-22T00:00:00Z