Amitriptyline is a TrkA and TrkB receptor agonist that promotes TrkA/TrkB heterodimerization and has potent neurotrophic activity
about
Neurosteroid dehydroepiandrosterone interacts with nerve growth factor (NGF) receptors, preventing neuronal apoptosisNovel small molecule activators of the Trk family of receptor tyrosine kinasesMetabolic reserve as a determinant of cognitive agingInhibition of acid sphingomyelinase by tricyclic antidepressants and analogonsAmitriptyline improves motor function via enhanced neurotrophin signaling and mitochondrial functions in the murine N171-82Q Huntington disease model.Amitriptyline-mediated cognitive enhancement in aged 3×Tg Alzheimer's disease mice is associated with neurogenesis and neurotrophic activityAntidepressant drugs transactivate TrkB neurotrophin receptors in the adult rodent brain independently of BDNF and monoamine transporter blockadeDisruption of aminergic signalling reveals novel compounds with distinct inhibitory effects on mosquito reproduction, locomotor function and survival.New treatments for chronic prostatitis/chronic pelvic pain syndromeTricyclic antidepressants delay the need for dopaminergic therapy in early Parkinson's disease.Small-molecule modulation of neurotrophin receptors: a strategy for the treatment of neurological disease.Tricyclic antidepressant amitriptyline activates fibroblast growth factor receptor signaling in glial cells: involvement in glial cell line-derived neurotrophic factor production.A monoclonal antibody TrkB receptor agonist as a potential therapeutic for Huntington's disease.Chronic amitriptyline treatment attenuates nigrostriatal degeneration and significantly alters trophic support in a rat model of parkinsonismMonoamine reuptake inhibitors in Parkinson's disease.Multiparametric Phenotypic Screening System for Profiling Bioactive Compounds Using Human Fetal Hippocampal Neural Stem/Progenitor Cells.Neuroprotective Effects of Voluntary Exercise in an Inherited Retinal Degeneration Mouse Model.Amitriptyline protects against TNF-α-induced atrophy and reduction in synaptic markers via a Trk-dependent mechanismAmitriptyline Activates TrkA to Aid Neuronal Growth and Attenuate Anesthesia-Induced Neurodegeneration in Rat Dorsal Root Ganglion Neurons.Advances in intravesical therapy for urinary tract disorders.A review: treatment of Alzheimer's disease discovered in repurposed agents.Losses and gains: chronic pain and altered brain morphology.Chronic Paroxetine Treatment Prevents the Emergence of Abnormal Electroencephalogram Oscillations in Huntington's Disease Mice.The hallucinogen 2,5-dimethoxy-4-iodoamphetamine hydrochloride activates neurotrophin receptors in a neuronal cell line and promotes neurites extension.Alleviation of pain in painful diabetic neuropathy.The predominant protective effect of tianeptine over other antidepressants in models of neuronal apoptosis: the effect blocked by inhibitors of MAPK/ERK1/2 and PI3-K/Akt pathways.High-Speed imaging reveals opposing effects of chronic stress and antidepressants on neuronal activity propagation through the hippocampal trisynaptic circuit.Beneficial effect of aspirin against interferon-α-2b-induced depressive behavior in Sprague Dawley rats.Acetylcholinesterase inhibitors rapidly activate Trk neurotrophin receptors in the mouse hippocampusImplication of NGF and endocannabinoid signaling in the mechanism of action of sesamol: a multi-target natural compound with therapeutic potential.Antidepressant Imipramine Protects Bupivacaine-Induced Neurotoxicity in Dorsal Root Ganglion Neurons Through Coactivation of TrkA and TrkB.The endocannabinoid system and NGF are involved in the mechanism of action of resveratrol: a multi-target nutraceutical with therapeutic potential in neuropsychiatric disorders.Nortriptyline inhibits aggregation and neurotoxicity of alpha-synuclein by enhancing reconfiguration of the monomeric form.Peripheral brain-derived neurotrophic factor (BDNF) as a biomarker for affective disorders?Enriched environment prevents hypobaric hypoxia induced neurodegeneration and is independent of antioxidant signaling.The CB₁ receptor-mediated endocannabinoid signaling and NGF: the novel targets of curcumin.Optogenetically controlled protein kinases for regulation of cellular signaling.Arsenic trioxide induces cell cycle arrest and affects Trk receptor expression in human neuroblastoma SK-N-SH cells.
P2860
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P2860
Amitriptyline is a TrkA and TrkB receptor agonist that promotes TrkA/TrkB heterodimerization and has potent neurotrophic activity
description
2009 nî lūn-bûn
@nan
2009 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Amitriptyline is a TrkA and Tr ...... s potent neurotrophic activity
@ast
Amitriptyline is a TrkA and Tr ...... s potent neurotrophic activity
@en
Amitriptyline is a TrkA and Tr ...... s potent neurotrophic activity
@nl
type
label
Amitriptyline is a TrkA and Tr ...... s potent neurotrophic activity
@ast
Amitriptyline is a TrkA and Tr ...... s potent neurotrophic activity
@en
Amitriptyline is a TrkA and Tr ...... s potent neurotrophic activity
@nl
prefLabel
Amitriptyline is a TrkA and Tr ...... s potent neurotrophic activity
@ast
Amitriptyline is a TrkA and Tr ...... s potent neurotrophic activity
@en
Amitriptyline is a TrkA and Tr ...... s potent neurotrophic activity
@nl
P2093
P2860
P3181
P1476
Amitriptyline is a TrkA and Tr ...... s potent neurotrophic activity
@en
P2093
Chi-Bun Chan
David Weinshenker
Keqiang Ye
Sung-Wuk Jang
P2860
P304
P3181
P356
10.1016/J.CHEMBIOL.2009.05.010
P407
P577
2009-06-01T00:00:00Z