The voltage-gated potassium channel Kv1.3 regulates peripheral insulin sensitivity - Wikidata - wikimedia - TriplyDB

The voltage-gated potassium channel Kv1.3 regulates peripheral insulin sensitivity

The voltage-gated potassium channel Kv1.3 regulates peripheral insulin sensitivity

http://www.wikidata.org/entity/Q24624806

about

Kv1.3 gene-targeted deletion alters longevity and reduces adiposity by increasing locomotion and metabolism in melanocortin-4 receptor-null mice Ion Channels in Obesity: Pathophysiology and Potential Therapeutic Targets Asparaginase treatment side-effects may be due to genes with homopolymeric Asn codons (Review-Hypothesis)1.2 Å X-ray structure of the renal potassium channel Kv1.3 T1 domain Mitral cells of the olfactory bulb perform metabolic sensing and are disrupted by obesity at the level of the Kv1.3 ion channel Twenty-five years since the discovery of endothelium-derived relaxing factor (EDRF): does a dysfunctional endothelium contribute to the development of type 2 diabetes?Hyperlipidemic diet causes loss of olfactory sensory neurons, reduces olfactory discrimination, and disrupts odor-reversal learning.The neurotoxic effects of ampicillin-associated gut bacterial imbalances compared to those of orally administered propionic acid in the etiology of persistent autistic features in rat pups: effects of various dietary regimens.Localization of Kv1.3 channels in presynaptic terminals of brainstem auditory neurons.Potassium secretion by voltage-gated potassium channel Kv1.3 in the rat kidney HIV-associated neurocognitive disorder: pathogenesis and therapeutic opportunities.Kv1.3: a potential pharmacological target for diabetes.Cell walls of Saccharomyces cerevisiae differentially modulated innate immunity and glucose metabolism during late systemic inflammation.Olfaction under metabolic influences.Stimulation of glucose uptake in murine soleus muscle and adipocytes by 5-(4-phenoxybutoxy)psoralen (PAP-1) may be mediated by Kv1.5 rather than Kv1.3.A C-terminal PDZ binding domain modulates the function and localization of Kv1.3 channels Kv1.3 contains an alternative C-terminal ER exit motif and is recruited into COPII vesicles by Sec24a.Neurotrophin B receptor kinase increases Kv subfamily member 1.3 (Kv1.3) ion channel half-life and surface expression Development of a sea anemone toxin as an immunomodulator for therapy of autoimmune diseases Regulation of insulin secretion and GLUT4 trafficking by the calcium sensor synaptotagmin VII.A highly selective mitochondria-targeting fluorescent K(+) sensor.The juxtaparanodal proteins CNTNAP2 and TAG1 regulate diet-induced obesity.Kv1.3 channels in postganglionic sympathetic neurons: expression, function, and modulation.The incretin hormone glucagon-like peptide 1 increases mitral cell excitability by decreasing conductance of a voltage-dependent potassium channel.Mitochondrial Ultrastructure and Glucose Signaling Pathways Attributed to the Kv1.3 Ion Channel.Selective Kv1.3 channel blocker as therapeutic for obesity and insulin resistance.K+ channel modulators for the treatment of neurological disorders and autoimmune diseases Electrophysiological and behavioral phenotype of insulin receptor defective mice.Awake intranasal insulin delivery modifies protein complexes and alters memory, anxiety, and olfactory behaviors.Novel Roles for the Insulin-Regulated Glucose Transporter-4 in Hippocampally Dependent Memory.Voltage-gated potassium channels as therapeutic targets.Kv1.3 potassium channels as a therapeutic target in multiple sclerosis.The Olfactory Bulb: A Metabolic Sensor of Brain Insulin and Glucose Concentrations via a Voltage-Gated Potassium Channel.Diabetes area participation analysis: a review of companies and targets described in the 2008 - 2010 patent literature.The voltage-dependent K(+) channels Kv1.3 and Kv1.5 in human cancer.Margatoxin-bound quantum dots as a novel inhibitor of the voltage-gated ion channel Kv1.3.Pharmacological inhibition of Kv1.3 fails to modulate insulin sensitivity in diabetic mice or human insulin-sensitive tissues.The voltage-gated potassium channel Kv1.3 is a promising multitherapeutic target against human pathologies.Awake, long-term intranasal insulin treatment does not affect object memory, odor discrimination, or reversal learning in mice.Kv1.3 inhibitors have differential effects on glucose uptake and AMPK activity in skeletal muscle cell lines and mouse ex vivo skeletal muscle.

P2860

Q24642217-DD860A8C-AB26-4A4F-B72E-C64DAB2E2590 Q26749884-FB84BA88-EF07-49AB-B0A0-1F9A4717C6DB Q26801165-7ACE9E85-FC25-4901-8D51-D642FF17E8B3 Q27687089-BAC50D2B-F2CB-45E9-9491-C4720CB2537C Q28477178-762EFDCE-83B5-4004-97D6-370E0222F0CE Q30352122-E1C6A58A-3F44-467E-8936-667D7F5F7A30 Q30409547-45712323-136D-4F75-8031-D9948F1E2C50 Q30414647-77C7F754-19DD-427B-806A-DC25EE49D5FF Q30495209-0E8CC902-C5CC-4919-9449-BCAA6B1F4626 Q33995090-36AEA21E-7FBD-44F4-99A2-72C4B4EFA960 Q34037622-64D0401D-B42E-49D4-8864-5F526117A0D3 Q34131276-3418CDB9-5698-4A4C-B2A2-01C804061B37 Q34137678-6ACA000B-4BFC-42AE-B644-647D6F54A79C Q34290268-50712A8B-B9EE-4907-A46F-03155F3D57CB Q34321503-1E523591-949C-45FE-9D11-517186AE50CD Q35175789-16CDAB80-DC7A-4C6F-BB8D-D8669F811A10 Q35686448-FEB85272-6104-4ECB-A257-A602408A7C83 Q35825865-4B254CC6-E5B8-4792-861D-DFC92B6B401E Q36097325-9DBCDADC-4012-441C-A832-CCEE061CF895 Q36371942-1A5D6275-B404-478D-BE9C-0CC1C3A029E7 Q36749715-CFF0D1D8-1626-41D8-803E-F83225ACD292 Q36833907-F3DE75A7-A632-4DCA-843D-22BE3F92C3CB Q36877707-22A8C346-46D5-4320-8190-13EA0CC156A2 Q36897100-904D00E5-8A77-49ED-B713-F1DB9C73F162 Q36913999-9BAD0BED-9F07-4225-B9F4-0BB61FF079E5 Q36932435-07EE4F59-19FD-4097-99D0-D82C428A9176 Q37162392-465B8086-4114-4C8E-B66B-D86A993F25B0 Q37332391-04809678-8C92-4864-8DD9-EEA28BF4A22C Q37425558-278F81CA-BFBE-4FC4-8124-4E377BF185EF Q37445092-4DCB7F8F-ADC7-47F3-A3E0-E7D9EF0DDA86 Q37464784-342BCB88-32B6-407A-AC25-75F8963AC221 Q37523986-45D281C4-3439-49F9-95EE-B0FDD5905E93 Q37791900-42BA78C3-7D21-4A0D-94D2-87495DA27743 Q37810292-77C5E5A4-E470-4C4B-8628-86A6E6D1C3F4 Q38153378-426EABC4-719D-465D-934E-4754DBE4DBFC Q38290139-F279D741-7953-4EC8-9397-3022597296CD Q38335118-0590C710-ABF3-4FAB-89A5-0B70EE660FFE Q38658556-54E9BB40-45C6-4B1C-81FA-C0956E29204C Q38929334-85415E46-9B0D-4850-AE39-0C556FC24C91 Q39094843-2AE04B44-E567-458C-A466-91287C609136

P2860

The voltage-gated potassium channel Kv1.3 regulates peripheral insulin sensitivity

http://www.wikidata.org/entity/Q24624806

description

2004 nî lūn-bûn

@nan

2004 թուականի Մարտին հրատարակուած գիտական յօդուած

@hyw

2004 թվականի մարտին հրատարակված գիտական հոդված

@hy

2004年の論文

@ja

2004年論文

@yue

2004年論文

@zh-hant

2004年論文

@zh-hk

2004年論文

@zh-mo

2004年論文

@zh-tw

2004年论文

@wuu

name

The voltage-gated potassium channel Kv1.3 regulates peripheral insulin sensitivity

@ast

The voltage-gated potassium channel Kv1.3 regulates peripheral insulin sensitivity

@en

The voltage-gated potassium channel Kv1.3 regulates peripheral insulin sensitivity

@nl

type

label

The voltage-gated potassium channel Kv1.3 regulates peripheral insulin sensitivity

@ast

The voltage-gated potassium channel Kv1.3 regulates peripheral insulin sensitivity

@en

The voltage-gated potassium channel Kv1.3 regulates peripheral insulin sensitivity

@nl

prefLabel

The voltage-gated potassium channel Kv1.3 regulates peripheral insulin sensitivity

@ast

The voltage-gated potassium channel Kv1.3 regulates peripheral insulin sensitivity

@en

The voltage-gated potassium channel Kv1.3 regulates peripheral insulin sensitivity

@nl

P1433

Q24624806-DB1BC866-6C11-4485-B1F3-79C540432E09

P1476

Q24624806-DC48B02A-1A44-4A88-BB23-87942A0C4438

P2093

Q24624806-5D2723E8-03C2-4995-A632-DB9146887272

Q24624806-71DA9591-0A1E-46A7-B0D5-FD0492ADBE5E

Q24624806-868FD630-4A02-468A-A941-60140692DA6B

Q24624806-979FD05E-90CF-4DCB-A9B6-585114B85B94

Q24624806-9AF8D960-B425-4C94-8939-990665DEAFBD

Q24624806-B59BCC4C-2AB7-4832-BB2D-598CCBD91037

Q24624806-F6F8659E-3EA3-4A15-BB15-07B438C2EF59

Q24624806-FE3EFC05-A28E-430A-9BE1-47C290C58B5F

P2860

Q24624806-18F7CD9F-E720-4DE5-909F-F3D1130C2619

Q24624806-1A080002-B624-4C7A-8D37-B2C5D4B25999

Q24624806-1BABDE14-68A5-4747-95BA-F188D324E247

Q24624806-1CA5A8F5-91CF-40D7-AF24-F0363351C0B8

Q24624806-1CB3483D-6724-4C18-9775-15C0C6A1A152

Q24624806-1E9B1BD4-193A-4DB0-94B1-5DAAD9FCB453

Q24624806-2FFF523E-B947-4032-A0C5-F0288C8A41A8

Q24624806-309666FD-9001-4ED1-A2B4-3824851A4D82

Q24624806-34870590-E4F3-4D53-9411-421C14FA1F22

Q24624806-44EE0062-9B57-4FAB-A9C7-073FC912CB18

P304

Q24624806-0FF9189C-7706-46D5-BA13-3BA6043705DA

P31

Q24624806-A477048E-6ACB-4DE0-AB87-C077C32298F3

P3181

Q24624806-86507EE4-8F56-48B8-8015-499AC529626A

P356

Q24624806-AFF3B23F-9DBC-46F9-9C10-13455EC22B30

P407

Q24624806-E2319A4C-B172-4B89-99DA-DBF6D2ED5C69

P433

Q24624806-26EA404E-4423-46E4-86D3-718B5E22B84F

P478

Q24624806-66A666DA-8332-4228-98B0-4D6D8256464F

P50

Q24624806-1542E376-F4D9-4B9F-B8C2-46990607EB17

P577

Q24624806-06F9D211-F3A6-4D1D-9B92-479257167DAF

P5875

Q24624806-B264F7AB-24AF-4E33-B96E-F39443D6F47A

P698

Q24624806-68D42727-0728-4A40-8A5A-E713A8605F16

P921

Q24624806-5A56CA63-9B79-481A-A0F1-4561496B4643

P932

Q24624806-6760ABB3-C630-4D52-B83E-400464D3466C

P3181

P356

PNAS.0308450100

P1433

Proceedings of the National Academy of Sciences of the United States of America

P1476

The voltage-gated potassium channel Kv1.3 regulates peripheral insulin sensitivity

@en

P2093

Gary V Desir

http://www.w3.org/2001/XMLSchema#string

Guoyong Li

http://www.w3.org/2001/XMLSchema#string

Jianchao Xu

http://www.w3.org/2001/XMLSchema#string

Leonard K Kaczmarek

http://www.w3.org/2001/XMLSchema#string

Peili Wang

http://www.w3.org/2001/XMLSchema#string

Richard A Flavell

http://www.w3.org/2001/XMLSchema#string

Yanling Wu

http://www.w3.org/2001/XMLSchema#string

Yanyan Li

http://www.w3.org/2001/XMLSchema#string

P2860

Molecular characterization of a voltage-gated potassium channel expressed in rat testis

Cloning, functional expression, and regulation of two K+ channels in human T lymphocytes

Expression and chromosomal localization of a lymphocyte K+ channel gene

Selective blockade of T lymphocyte K(+) channels ameliorates experimental autoimmune encephalomyelitis, a model for multiple sclerosis

The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307)

Up-regulation of the IKCa1 potassium channel during T-cell activation. Molecular mechanism and functional consequences

The voltage-gated potassium channel Kv1.3 regulates energy homeostasis and body weight

Molecular basis of functional diversity of voltage-gated potassium channels in mammalian brain

A family of three mouse potassium channel genes with intronless coding regions

Sensitivity of native and cloned hippocampal delayed-rectifier potassium channels to verapamil

P304

3112-3117

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P3181

1491117

http://www.w3.org/2001/XMLSchema#string

P356

10.1073/PNAS.0308450100

http://www.w3.org/2001/XMLSchema#string

P407

P433

9

http://www.w3.org/2001/XMLSchema#string

P478

101

http://www.w3.org/2001/XMLSchema#string

P50

Pandelakis A. Koni

P577

2004-02-23T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

5263277

http://www.w3.org/2001/XMLSchema#string

P698

14981264

http://www.w3.org/2001/XMLSchema#string

P921

P932

365752

http://www.w3.org/2001/XMLSchema#string