The Ewing's sarcoma EWS/FLI-1 fusion gene encodes a more potent transcriptional activator and is a more powerful transforming gene than FLI-1
about
Adenosine transporter ENT4 is a direct target of EWS/WT1 translocation product and is highly expressed in desmoplastic small round cell tumorEWS/FLI mediates transcriptional repression via NKX2.2 during oncogenic transformation in Ewing's sarcomaIFN-beta induces serine phosphorylation of Stat-1 in Ewing's sarcoma cells and mediates apoptosis via induction of IRF-1 and activation of caspase-7The PAX3-FKHR fusion protein created by the t(2;13) translocation in alveolar rhabdomyosarcomas is a more potent transcriptional activator than PAX3SRE elements are binding sites for the fusion protein EWS-FLI-1EWS-erg and EWS-Fli1 fusion transcripts in Ewing's sarcoma and primitive neuroectodermal tumors with variant translocationsCD99 inhibits neural differentiation of human Ewing sarcoma cells and thereby contributes to oncogenesisA developmental switch in the response of DRG neurons to ETS transcription factor signalingThe biology of DHX9 and its potential as a therapeutic targetTherapeutic opportunities in Ewing sarcoma: EWS-FLI inhibition via LSD1 targetingWhat Do We Know about the Role of miRNAs in Pediatric Sarcoma?Functions of heterogeneous nuclear ribonucleoproteins in stem cell potency and differentiationDiagnostic gold standard for soft tissue tumours: morphology or molecular genetics?Identification of an RNA binding specificity for the potential splicing factor TLSThe N-terminal domain of human TAFII68 displays transactivation and oncogenic propertiesA novel effector domain from the RNA-binding protein TLS or EWS is required for oncogenic transformation by CHOPThe prooncoprotein EWS binds calmodulin and is phosphorylated by protein kinase C through an IQ domainThe proto-oncoprotein SYT interacts with SYT-interacting protein/co-activator activator (SIP/CoAA), a human nuclear receptor co-activator with similarity to EWS and TLS/FUS family of proteinsMolecular analysis of a t(11;22) translocation junction in a case of Ewing's sarcomaSignature-based small molecule screening identifies cytosine arabinoside as an EWS/FLI modulator in Ewing sarcomaFOXM1 is an oncogenic mediator in Ewing SarcomaOlfactory neuroblastoma is a peripheral primitive neuroectodermal tumor related to Ewing sarcomaExposure on cell surface and extensive arginine methylation of ewing sarcoma (EWS) protein.Junction region of EWS-FLI1 fusion protein has a dominant negative effect in Ewing's sarcoma in vitro.Integrated analysis of omics data using microRNA-target mRNA network and PPI network reveals regulation of Gnai1 function in the spinal cord of Ews/Ewsr1 KO mice.Translocations, cancer and the puzzle of specificity.EWS/FLI1 oncogene activates caspase 3 transcription and triggers apoptosis in vivo.New diagnostic modalities in soft tissue sarcoma.High ALDH activity identifies chemotherapy-resistant Ewing's sarcoma stem cells that retain sensitivity to EWS-FLI1 inhibitionCombined experience of six independent laboratories attempting to create an Ewing sarcoma mouse modelEwing Sarcoma, an enigmatic malignancy of likely progenitor cell origin, driven by transcription factor oncogenic fusions.The EWS/TEC fusion protein encoded by the t(9;22) chromosomal translocation in human chondrosarcomas is a highly potent transcriptional activator.A domain of TEL conserved in a subset of ETS proteins defines a specific oligomerization interface essential to the mitogenic properties of the TEL-PDGFR beta oncoprotein.The ETV6-NTRK3 gene fusion encodes a chimeric protein tyrosine kinase that transforms NIH3T3 cells.The role of Fli-1 in normal cell function and malignant transformation.PDGF-C is an EWS/FLI induced transforming growth factor in Ewing family tumors.Dual transforming activities of the FUS (TLS)-ERG leukemia fusion protein conferred by two N-terminal domains of FUS (TLS).Negative and translation termination-dependent positive control of FLI-1 protein synthesis by conserved overlapping 5' upstream open reading frames in Fli-1 mRNA.An engineered PAX3-KRAB transcriptional repressor inhibits the malignant phenotype of alveolar rhabdomyosarcoma cells harboring the endogenous PAX3-FKHR oncogeneGene expression profiling of peripheral blood cells: new insights into Ewing sarcoma biology and clinical applications.
P2860
Q21092207-7AB2E514-D6C4-4026-AC9D-5EA1927AC60AQ21144325-2B19CD4A-7132-44BB-BD17-FDF40DBDDEF0Q22254705-B0E7BDE6-B962-4C34-A980-DC8A51CB14C5Q24313754-119D3E56-0FEC-47CD-A066-161D3668C46CQ24546126-494002E6-6CD8-417E-A689-2811A8A2EFE3Q24634316-F35954E5-C8BF-491D-8902-53C22D4D228EQ24642797-95E56034-190F-46F8-B769-2BADC36C6D0EQ24791095-253F209C-3FD6-4680-8369-C93F4ABDEF55Q26749166-412BE83B-FF2E-4D0B-A244-621FED8B7561Q26768602-37F922C0-A018-48D5-B704-A497DE99A800Q26800124-7ACEA528-AD2D-4B54-99A7-B78746667CD4Q26849397-CA9C642B-A0D8-408E-958D-6745AD2E0C44Q27777801-4BE1F94E-22B2-4F9C-A21A-CE0D9BD6DECBQ28138875-D0D07F77-6C90-4170-A2A1-71C468AAE333Q28142781-BDC06C0D-35A7-48E8-94AF-F787D66355AFQ28240554-29A5B2B4-E0CF-4923-B1A4-E62E29CA0CF1Q28252199-1CD1DB75-A911-488C-99E9-B4B61E5943FDQ28277223-18D7EAD4-F5D6-420D-9CEE-C01A22D07100Q28288246-0E6A2C91-06B5-4E58-93B5-DB71782F56A0Q28469179-F39EC451-06A0-4146-ACBC-70CC0AE27DB0Q28485291-F760D82C-8616-4B5C-BF94-4E7F80476AF0Q30453924-16BE3672-3E47-4398-BE30-B93E2CECA00DQ30984846-955A0559-5088-4E23-A647-12B34D200CD8Q31106858-E48ECF7F-9BEB-425D-BD82-DBBEF47D5EB9Q31122090-F379705E-2DEF-47C0-AA81-BEC965A551A3Q33368676-3F9E4F9A-8876-429F-AB51-EF66025C12FBQ33638434-5B3A74B0-3D9A-4BFC-88D5-DC1BDC377639Q33685499-739C0CA9-9802-4C1D-B041-8C466A4AA038Q33750221-411C4D71-430A-491F-A1EF-4A8233312667Q33798299-4FC92D32-F9AC-4014-BBB4-60584C94C5DDQ33861072-798114DB-78F4-4C76-9A27-6F45B69DA0E1Q33864130-497B390F-B088-4E44-A90B-9B4B20653743Q33885920-F91A8270-B4BC-492A-891E-8F62E20787ACQ33892265-81F1E3FC-003C-483A-9901-2F2BA344517FQ33933215-53BA2BA8-21DB-4291-A9C9-BDD14C64E37CQ33943460-26025601-6649-40FB-8C17-AC62167F4D64Q33960227-3076E0AB-A18C-4FE2-9875-E83065CA67AEQ33963039-3028C234-A341-47E7-B3E4-91799029EE1EQ33964561-BB654235-AEE5-4E49-93AA-82BAE19A631DQ33992622-16F72C52-EDC8-464C-B786-4EA2971CC996
P2860
The Ewing's sarcoma EWS/FLI-1 fusion gene encodes a more potent transcriptional activator and is a more powerful transforming gene than FLI-1
description
1993 nî lūn-bûn
@nan
1993 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1993 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
name
The Ewing's sarcoma EWS/FLI-1 ...... l transforming gene than FLI-1
@ast
The Ewing's sarcoma EWS/FLI-1 ...... l transforming gene than FLI-1
@en
The Ewing's sarcoma EWS/FLI-1 ...... l transforming gene than FLI-1
@nl
type
label
The Ewing's sarcoma EWS/FLI-1 ...... l transforming gene than FLI-1
@ast
The Ewing's sarcoma EWS/FLI-1 ...... l transforming gene than FLI-1
@en
The Ewing's sarcoma EWS/FLI-1 ...... l transforming gene than FLI-1
@nl
prefLabel
The Ewing's sarcoma EWS/FLI-1 ...... l transforming gene than FLI-1
@ast
The Ewing's sarcoma EWS/FLI-1 ...... l transforming gene than FLI-1
@en
The Ewing's sarcoma EWS/FLI-1 ...... l transforming gene than FLI-1
@nl
P2093
P2860
P3181
P356
P1476
The Ewing's sarcoma EWS/FLI-1 ...... l transforming gene than FLI-1
@en
P2093
L B Lunsford
S L Lessnick
P2860
P304
P3181
P356
10.1128/MCB.13.12.7393
P407
P577
1993-12-01T00:00:00Z