The t(15;17) translocation of acute promyelocytic leukaemia fuses the retinoic acid receptor alpha gene to a novel transcribed locus
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The epigenetic regulator UHRF1 promotes ubiquitination-mediated degradation of the tumor-suppressor protein promyelocytic leukemia proteinArsenic-induced SUMO-dependent recruitment of RNF4 into PML nuclear bodiesFusion of the dominant negative transcription regulator CHOP with a novel gene FUS by translocation t(12;16) in malignant liposarcomaIntrachromosomal rearrangements fusing L-myc and rlf in small-cell lung cancerAmino-terminal protein-protein interaction motif (POZ-domain) is responsible for activities of the promyelocytic leukemia zinc finger-retinoic acid receptor-alpha fusion proteinLeukemia-associated retinoic acid receptor alpha fusion partners, PML and PLZF, heterodimerize and colocalize to nuclear bodiesEvidence for covalent modification of the nuclear dot-associated proteins PML and Sp100 by PIC1/SUMO-1RIG-E, a human homolog of the murine Ly-6 family, is induced by retinoic acid during the differentiation of acute promyelocytic leukemia cellA fusion protein formed by L-myc and a novel gene in SCLCThe t(7;11)(p15;p15) translocation in acute myeloid leukaemia fuses the genes for nucleoporin NUP98 and class I homeoprotein HOXA9Cellular localization, expression, and structure of the nuclear dot protein 52Identification and characterization of a leukocyte-specific component of the nuclear bodyPML, a growth suppressor disrupted in acute promyelocytic leukemiaThe interferon (IFN)-stimulated gene Sp100 promoter contains an IFN-gamma activation site and an imperfect IFN-stimulated response element which mediate type I IFN inducibilityThe promyelocytic leukemia gene product (PML) forms stable complexes with the retinoblastoma proteinFunctional architecture in the cell nucleusSp110 localizes to the PML-Sp100 nuclear body and may function as a nuclear hormone receptor transcriptional coactivatorStructure, localization and transcriptional properties of two classes of retinoic acid receptor alpha fusion proteins in acute promyelocytic leukemia (APL): structural similarities with a new family of oncoproteinsPbx1 is converted into a transcriptional activator upon acquiring the N-terminal region of E2A in pre-B-cell acute lymphoblastoid leukemiaPLZF-RAR alpha fusion proteins generated from the variant t(11;17)(q23;q21) translocation in acute promyelocytic leukemia inhibit ligand-dependent transactivation of wild-type retinoic acid receptorsFusion between a novel Krüppel-like zinc finger gene and the retinoic acid receptor-alpha locus due to a variant t(11;17) translocation associated with acute promyelocytic leukaemiaRetinoids down-regulate telomerase and telomere length in a pathway distinct from leukemia cell differentiationRearrangements of the retinoic acid receptor alpha and promyelocytic leukemia zinc finger genes resulting from t(11;17)(q23;q21) in a patient with acute promyelocytic leukemiaThe translocation (6;9), associated with a specific subtype of acute myeloid leukemia, results in the fusion of two genes, dek and can, and the expression of a chimeric, leukemia-specific dek-can mRNAThe Ewing's sarcoma EWS/FLI-1 fusion gene encodes a more potent transcriptional activator and is a more powerful transforming gene than FLI-1The hybrid PAX3-FKHR fusion protein of alveolar rhabdomyosarcoma transforms fibroblasts in cultureItraconazole and arsenic trioxide inhibit Hedgehog pathway activation and tumor growth associated with acquired resistance to smoothened antagonistsMolecular cloning and expression of human cDNAs encoding a novel DNA ligase IV and DNA ligase III, an enzyme active in DNA repair and recombinationSMRT corepressor interacts with PLZF and with the PML-retinoic acid receptor alpha (RARalpha) and PLZF-RARalpha oncoproteins associated with acute promyelocytic leukemiaCloning of a gene (RIG-G) associated with retinoic acid-induced differentiation of acute promyelocytic leukemia cells and representing a new member of a family of interferon-stimulated genesPML is critical for ND10 formation and recruits the PML-interacting protein daxx to this nuclear structure when modified by SUMO-1Antisense oligonucleotides from the stage-specific myeloid zinc finger gene MZF-1 inhibit granulopoiesis in vitroRetinoic acid and arsenic for treating acute promyelocytic leukemiaCullin 3 Ubiquitin Ligases in Cancer Biology: Functions and Therapeutic ImplicationsCul3-KLHL20 ubiquitin ligase: physiological functions, stress responses, and disease implicationsThe cell biology of disease: Acute promyelocytic leukemia, arsenic, and PML bodiesHow animal models of leukaemias have already benefited patientsPML is required for telomere stability in non-neoplastic human cellsMechanisms of action and resistance to all-trans retinoic acid (ATRA) and arsenic trioxide (As2O 3) in acute promyelocytic leukemia.Targeting of leukemia-initiating cells in acute promyelocytic leukemia
P2860
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P2860
The t(15;17) translocation of acute promyelocytic leukaemia fuses the retinoic acid receptor alpha gene to a novel transcribed locus
description
1990 nî lūn-bûn
@nan
1990 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1990 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
1990年の論文
@ja
1990年論文
@yue
1990年論文
@zh-hant
1990年論文
@zh-hk
1990年論文
@zh-mo
1990年論文
@zh-tw
1990年论文
@wuu
name
The t(15;17) translocation of ...... e to a novel transcribed locus
@ast
The t(15;17) translocation of ...... e to a novel transcribed locus
@en
The t(15;17) translocation of ...... e to a novel transcribed locus
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type
label
The t(15;17) translocation of ...... e to a novel transcribed locus
@ast
The t(15;17) translocation of ...... e to a novel transcribed locus
@en
The t(15;17) translocation of ...... e to a novel transcribed locus
@nl
prefLabel
The t(15;17) translocation of ...... e to a novel transcribed locus
@ast
The t(15;17) translocation of ...... e to a novel transcribed locus
@en
The t(15;17) translocation of ...... e to a novel transcribed locus
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P2093
P3181
P356
P1433
P1476
The t(15;17) translocation of ...... e to a novel transcribed locus
@en
P2093
P2888
P304
P3181
P356
10.1038/347558A0
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P577
1990-10-11T00:00:00Z
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1041963568