CADASIL: Notch signaling defect or protein accumulation problem?
about
A CADASIL-mutated Notch 3 receptor exhibits impaired intracellular trafficking and maturation but normal ligand-induced signaling.Pathogenic mutations associated with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy differently affect Jagged1 binding and Notch3 activity via the RBP/JK signaling Pathway.An overview of notch signaling in adult tissue renewal and maintenance.CADASIL: what component of the vessel wall is really a target for Notch 3 gene mutations?CADASIL management or what to do when there is little one can do.A Notch updated.Notch and disease: a growing field.Targeting Notch3 in Hepatocellular Carcinoma: Molecular Mechanisms and Therapeutic Perspectives.Increased expression of Notch1 in temporal lobe epilepsy: animal models and clinical evidenceCADASIL syndrome in a large Turkish kindred caused by the R90C mutation in the Notch3 receptor.Transgenic mice expressing mutant Notch3 develop vascular alterations characteristic of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy.
P2860
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P2860
CADASIL: Notch signaling defect or protein accumulation problem?
description
2000 nî lūn-bûn
@nan
2000 թուականի Մարտին հրատարակուած գիտական յօդուած
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2000年の論文
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2000年論文
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2000年論文
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CADASIL: Notch signaling defect or protein accumulation problem?
@ast
CADASIL: Notch signaling defect or protein accumulation problem?
@en
CADASIL: Notch signaling defect or protein accumulation problem?
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label
CADASIL: Notch signaling defect or protein accumulation problem?
@ast
CADASIL: Notch signaling defect or protein accumulation problem?
@en
CADASIL: Notch signaling defect or protein accumulation problem?
@nl
prefLabel
CADASIL: Notch signaling defect or protein accumulation problem?
@ast
CADASIL: Notch signaling defect or protein accumulation problem?
@en
CADASIL: Notch signaling defect or protein accumulation problem?
@nl
P2860
P356
P1476
CADASIL: Notch signaling defect or protein accumulation problem?
@en
P2093
N B Spinner
P2860
P356
10.1172/JCI9511
P407
P577
2000-03-01T00:00:00Z