Pathogenic mutations associated with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy differently affect Jagged1 binding and Notch3 activity via the RBP/JK signaling Pathway.
about
Mutations of NOTCH3 in childhood pulmonary arterial hypertensionBiochemical characterization and cellular effects of CADASIL mutants of NOTCH3Notch3 is a major regulator of vascular tone in cerebral and tail resistance arteriesDistinct phenotypic and functional features of CADASIL mutations in the Notch3 ligand binding domainCerebrovascular dysfunction and microcirculation rarefaction precede white matter lesions in a mouse genetic model of cerebral ischemic small vessel diseaseCADASIL and CARASIL.Targeting specific regions of the Notch3 ligand-binding domain induces apoptosis and inhibits tumor growth in lung cancer.Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy: a genetic cause of cerebral small vessel disease.An overview of notch signaling in adult tissue renewal and maintenance.Functional analysis of a recurrent missense mutation in Notch3 in CADASILCharacterization of CADASIL among the Han Chinese in Taiwan: Distinct Genotypic and Phenotypic Profiles.Proteome analysis of cultivated vascular smooth muscle cells from a CADASIL patient.Notch signaling, brain development, and human disease.Vascular Notch proteins and Notch signaling in the peri-implantation mouse uterus.CADASIL: a critical look at a Notch disease.CADASIL mutations and shRNA silencing of NOTCH3 affect actin organization in cultured vascular smooth muscle cells.Association of Notch3 single-nucleotide polymorphisms and lacunar infarctions in patients.Notch signaling in the vasculatureAbnormal recruitment of extracellular matrix proteins by excess Notch3 ECD: a new pathomechanism in CADASILCollagen represses canonical Notch signaling and binds to Notch ectodomainStroke-related translational research.notch3 is essential for oligodendrocyte development and vascular integrity in zebrafish.Genetics of stroke: a review of recent advances.Nas transgenic mouse line allows visualization of Notch pathway activity in vivo.Targeted next generation sequencing identifies novel NOTCH3 gene mutations in CADASIL diagnostics patients.Genetic animal models of cerebral vasculopathies.CADASIL: experimental insights from animal models.Review: molecular genetics and pathology of hereditary small vessel diseases of the brain.Notch and disease: a growing field.CADASIL: Treatment and Management Options.CADASIL mutant NOTCH3(R90C) decreases the viability of HS683 oligodendrocytes via apoptosis.Clinical features and mutation spectrum in Chinese patients with CADASIL: A multicenter retrospective study.Genetics of Migraine: Insights into the Molecular Basis of Migraine Disorders.Notch-3 receptor activation drives inflammation and fibrosis following tubulointerstitial kidney injury.Signaling required for blood vessel maintenance: molecular basis and pathological manifestations.Differential subcellular localization regulates c-Cbl E3 ligase activity upon Notch3 protein in T-cell leukemia.YB-1 acts as a ligand for Notch-3 receptors and modulates receptor activation.Mice carrying a R142C Notch 3 knock-in mutation do not develop a CADASIL-like phenotype.Notch Signaling in Development, Tissue Homeostasis, and Disease.Vascular dementia: Diagnostic criteria and supplementary exams. Recommendations of the Scientific Department of Cognitive Neurology and Aging of the Brazilian Academy of Neurology. Part I.
P2860
Q28387429-7AA2F7AD-3EA0-4F22-9D94-9408A453D1B9Q28483874-131552C6-FD44-4A49-BB70-82E75154C212Q30486605-007B53C2-10BC-46CF-BDCE-E3372CF57723Q30487788-CCB0A2A4-7AEE-45E2-B616-C6FF175E7079Q30492865-2101009A-F378-425E-BC1A-1F0D20E2A305Q30861866-B774E3DF-9C2F-4C33-903B-E1A5D3AAA200Q33523430-F6E97C1F-E311-4C43-AD80-6B88159B914DQ33775902-0AB743B2-D772-449B-8AA6-C9C0F70C301FQ35180702-1D2FDD93-9982-4B61-A533-FDF0DC79E3C9Q35489815-A5163CC4-A5C5-4E6A-9F72-6185EC112F73Q35755963-157498BF-E037-4AA2-98EC-18E087468F15Q35868667-EA65DD94-0A91-48E0-B843-B849BF98F22FQ36092136-626300C3-4534-4AA2-8523-77972C02A899Q36337071-5DBFF0DB-999A-4FDD-AB6A-B425175B9721Q36409731-DC4D5449-4CFA-455E-8F86-FA111F8E6300Q36459076-101E2A09-850E-4549-966B-F2F60ED201E2Q36502234-381B6EC4-2EC6-4919-9C15-2020107C7BCFQ36861805-0C3A0215-C83C-43F4-B752-1A701FF072D0Q36904906-7ACDA203-112D-45CE-B65D-688C352433D6Q36931174-6A3FD815-2795-4890-BC26-8921DDF48E7BQ36953709-AC5333A1-AC7E-4344-AFD4-F2BF12F9D51CQ37137791-F66BB375-3AA0-4135-B1E4-82BA5DD3D843Q37206266-932E1ABC-EA25-407F-9BE3-DEC277873EB9Q37325961-CF83114D-B968-4564-9FD7-3643E5052F1EQ37436780-4824BCDE-D9A1-498C-8C30-2A1D9E7A0214Q37542635-A512171C-9F4E-43CE-A5B5-F85F89F761EEQ37793683-6E65B1D2-BCE3-4AA9-BD64-A71FF92840EFQ37808273-E41822AC-0D6D-45FE-A951-70303B68D563Q37988987-9494DE1E-5EA8-4F65-BAEE-833CADBD87F0Q38663098-807332B5-E2FD-430B-B6F3-B1DD8BAD228AQ38672393-6EEF7022-DE35-4FE6-A78C-AA6C46031CAFQ38677884-E8288599-0270-40D9-A0B9-53C6D03ABB8AQ39167599-20935504-A321-4A84-8032-6C0FB5F6910AQ39313049-97FE7E4F-EF1D-4B2B-9599-37F98A03F1B2Q39752032-EFE46928-F684-4D5C-BD38-E80686B3AF09Q39766221-C9A48583-86DD-44CF-B067-3B02A76C43E5Q39819288-C387C83F-3CE0-4EA7-9EE2-09B7247686CFQ45220730-35018284-21C6-41FE-BB2F-CDC0B2933276Q46795621-8EE5B57D-CCE2-4998-975C-2E1206BED8E7Q47137433-10E5C9DC-4D20-42BF-9B21-E5BCF0CBBC8B
P2860
Pathogenic mutations associated with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy differently affect Jagged1 binding and Notch3 activity via the RBP/JK signaling Pathway.
description
2004 nî lūn-bûn
@nan
2004 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Pathogenic mutations associate ...... the RBP/JK signaling Pathway.
@ast
Pathogenic mutations associate ...... the RBP/JK signaling Pathway.
@en
type
label
Pathogenic mutations associate ...... the RBP/JK signaling Pathway.
@ast
Pathogenic mutations associate ...... the RBP/JK signaling Pathway.
@en
prefLabel
Pathogenic mutations associate ...... the RBP/JK signaling Pathway.
@ast
Pathogenic mutations associate ...... the RBP/JK signaling Pathway.
@en
P2093
P2860
P356
P1476
Pathogenic mutations associate ...... the RBP/JK signaling Pathway.
@en
P2093
Florence Riant
Marie Monet
Valérie Domenga
P2860
P304
P356
10.1086/381506
P407
P577
2004-01-08T00:00:00Z