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The ancient drug salicylate directly activates AMP-activated protein kinase

The ancient drug salicylate directly activates AMP-activated protein kinase

http://www.wikidata.org/entity/Q24630758

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Regulation and function of AMPK in physiology and diseases Multiple Targets of Salicylic Acid and Its Derivatives in Plants and Animals AMPK activators: mechanisms of action and physiological activities Regulation of AMP-activated protein kinase by natural and synthetic activators New concepts and challenges in the clinical translation of cancer preventive therapies: the role of pharmacodynamic biomarkers Mitochondrial targets for pharmacological intervention in human disease Islet inflammation: a unifying target for diabetes treatment?AMP-activated protein kinase: a target for drugs both ancient and modern Something old, something new and something very old: drugs for treating type 2 diabetes AMPK: opposing the metabolic changes in both tumour cells and inflammatory cells?AMPK: a target for drugs and natural products with effects on both diabetes and cancer AMPK: An emerging target for modification of injury-induced pain plasticity.Chemopreventive drugs: mechanisms via inhibition of cancer stem cells in colorectal cancer Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits Structural basis of AMPK regulation by small molecule activators The β subunit of yeast AMP-activated protein kinase directs substrate specificity in response to alkaline stress Adenosine monophosphate-activated protein kinase-based classification of diabetes pharmacotherapy Controls of Nuclear Factor-Kappa B Signaling Activity by 5'-AMP-Activated Protein Kinase Activation With Examples in Human Bladder Cancer Cells AMP-activated protein kinase: a cellular energy sensor that comes in 12 flavours Dissecting the Dual Role of AMPK in Cancer: From Experimental to Human Studies Mitochondrial hormesis and diabetic complications Xenohormetic and anti-aging activity of secoiridoid polyphenols present in extra virgin olive oil: a new family of gerosuppressant agents Shizukaol D isolated from Chloranthus japonicas inhibits AMPK-dependent lipid content in hepatic cells by inducing mitochondrial dysfunction Xanthene derivatives increase glucose utilization through activation of LKB1-dependent AMP-activated protein kinase Human GAPDH Is a Target of Aspirin's Primary Metabolite Salicylic Acid and Its Derivatives Investigation of salicylate hepatic responses in comparison with chemical analogues of the drug Salicylate, diflunisal and their metabolites inhibit CBP/p300 and exhibit anticancer activity Treatment of nonalcoholic fatty liver disease: role of AMPK.Adenosine Monophosphate-activated Protein Kinase (AMPK) Activators For the Prevention, Treatment and Potential Reversal of Pathological Pain.Resveratrol and aspirin eliminate tetraploid cells for anticancer chemoprevention.Carboxylation of Phenols with CO2 at Atmospheric Pressure.Emerging Metabolic Therapies in Pulmonary Arterial Hypertension.AMP-activated protein kinase regulates intraocular pressure, extracellular matrix, and cytoskeleton in trabecular meshwork.The influence of Cox-2 and bioactive lipids on hematological cancers.AMPK activation--protean potential for boosting healthspan.Muscle uncoupling protein 3 overexpression mimics endurance training and reduces circulating biomarkers of incomplete β-oxidation.Induction of Colonic Regulatory T Cells by Mesalamine by Activating the Aryl Hydrocarbon Receptor Rice Bran Metabolome Contains Amino Acids, Vitamins & Cofactors, and Phytochemicals with Medicinal and Nutritional Properties.Salsalate ameliorates metabolic disturbances by reducing inflammation in spontaneously hypertensive rats expressing human C-reactive protein and by activating brown adipose tissue in nontransgenic controls Effect of salsalate on insulin action, secretion, and clearance in nondiabetic, insulin-resistant individuals: a randomized, placebo-controlled study

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The ancient drug salicylate directly activates AMP-activated protein kinase

http://www.wikidata.org/entity/Q24630758

description

2012 nî lūn-bûn

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2012 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2012 թվականի մայիսին հրատարակված գիտական հոդված

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年论文

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name

The ancient drug salicylate directly activates AMP-activated protein kinase

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The ancient drug salicylate directly activates AMP-activated protein kinase

@en

The ancient drug salicylate directly activates AMP-activated protein kinase

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type

label

The ancient drug salicylate directly activates AMP-activated protein kinase

@ast

The ancient drug salicylate directly activates AMP-activated protein kinase

@en

The ancient drug salicylate directly activates AMP-activated protein kinase

@nl

prefLabel

The ancient drug salicylate directly activates AMP-activated protein kinase

@ast

The ancient drug salicylate directly activates AMP-activated protein kinase

@en

The ancient drug salicylate directly activates AMP-activated protein kinase

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SCIENCE.1215327

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The ancient drug salicylate directly activates AMP-activated protein kinase

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Bruce E Kemp

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Cyrille Chevtzoff

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Darya Zibrova

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Fiona A Ross

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Gregory R Steinberg

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Jonathan D Schertzer

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Katherine J Walker

http://www.w3.org/2001/XMLSchema#string

Kei Sakamoto

http://www.w3.org/2001/XMLSchema#string

Kevin A Green

http://www.w3.org/2001/XMLSchema#string

Kirsty J Mustard

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P2860

Role of AMP-activated protein kinase in mechanism of metformin action

Structure of mammalian AMPK and its regulation by ADP

Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta

Mechanism by which high-dose aspirin improves glucose metabolism in type 2 diabetes

Aspirin inhibits serine phosphorylation of insulin receptor substrate 1 in tumor necrosis factor-treated cells through targeting multiple serine kinases

Continuous fatty acid oxidation and reduced fat storage in mice lacking acetyl-CoA carboxylase 2

Concentration-response relationships for salicylate-induced ototoxicity in normal volunteers.

AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy

Jasmonate and salicylate as global signals for defense gene expression.

AMPK beta1 deletion reduces appetite, preventing obesity and hepatic insulin resistance.

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918-922

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scholarly article

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478229

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10.1126/SCIENCE.1215327

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6083

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336

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David Grahame Hardie

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2012-04-19T00:00:00Z

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224769751

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22517326

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