about
AMP-Activated Protein Kinase in Metabolic Control and Insulin SignalingCharacterization of AMP-activated protein kinase gamma-subunit isoforms and their role in AMP bindingThe ancient drug salicylate directly activates AMP-activated protein kinaseAMP-activated protein kinase: a target for drugs both ancient and modernAMPK: opposing the metabolic changes in both tumour cells and inflammatory cells?Analysis of the LKB1-STRAD-MO25 complexAMP-activated protein kinase mediates phenobarbital induction of CYP2B gene expression in hepatocytes and a newly derived human hepatoma cell lineA novel short splice variant of the tumour suppressor LKB1 is required for spermiogenesisCalmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinaseAge-related HMG-CoA reductase deregulation depends on ROS-induced p38 activationThe alpha1 and alpha2 isoforms of the AMP-activated protein kinase have similar activities in rat liver but exhibit differences in substrate specificity in vitroAMP-activated/SNF1 protein kinases: conserved guardians of cellular energyThe AMP-activated/SNF1 protein kinase subfamily: metabolic sensors of the eukaryotic cell?Histological evaluation of AMPK signalling in primary breast cancerStearoyl-CoA desaturase 1 deficiency increases fatty acid oxidation by activating AMP-activated protein kinase in liver.The laforin-malin complex, involved in Lafora disease, promotes the incorporation of K63-linked ubiquitin chains into AMP-activated protein kinase beta subunits.A novel domain in AMP-activated protein kinase causes glycogen storage bodies similar to those seen in hereditary cardiac arrhythmias.Activity of LKB1 and AMPK-related kinases in skeletal muscle: effects of contraction, phenformin, and AICAR.Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin.Glycogen content regulates peroxisome proliferator activated receptor-∂ (PPAR-∂) activity in rat skeletal muscleAMP-activated protein kinase and hypoxic pulmonary vasoconstrictionUrocortin 3 transgenic mice exhibit a metabolically favourable phenotype resisting obesity and hyperglycaemia on a high-fat diet.Minireview: the AMP-activated protein kinase cascade: the key sensor of cellular energy status.Phosphorylation of the voltage-gated potassium channel Kv2.1 by AMP-activated protein kinase regulates membrane excitabilityAMP-activated protein kinase: a master switch in glucose and lipid metabolism.Aging-associated reductions in AMP-activated protein kinase activity and mitochondrial biogenesisAMP-activated protein kinase: the guardian of cardiac energy status.The AMP-activated protein kinase pathway--new players upstream and downstream.Defining the contribution of AMP-activated protein kinase (AMPK) and protein kinase C (PKC) in regulation of glucose uptake by metformin in skeletal muscle cellsNew roles for the LKB1-->AMPK pathway.AMPK promotes p53 acetylation via phosphorylation and inactivation of SIRT1 in liver cancer cells.Mechanism of action of A-769662, a valuable tool for activation of AMP-activated protein kinase.AMP-activated protein kinase--development of the energy sensor concept.AMP-activated protein kinase as a drug target.Potential role of TBC1D4 in enhanced post-exercise insulin action in human skeletal muscle.Role of AMP-activated protein kinase in the metabolic syndrome and in heart disease.AMPK: a key regulator of energy balance in the single cell and the whole organism.Association of AMP-activated protein kinase subunits with glycogen particles as revealed in situ by immunoelectron microscopy.AMP-activated protein kinase--a sensor of glycogen as well as AMP and ATP?Development of protein kinase activators: AMPK as a target in metabolic disorders and cancer.
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P50
description
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
David Grahame Hardie
@ast
David Grahame Hardie
@en
David Grahame Hardie
@es
David Grahame Hardie
@nl
type
label
David Grahame Hardie
@ast
David Grahame Hardie
@en
David Grahame Hardie
@es
David Grahame Hardie
@nl
prefLabel
David Grahame Hardie
@ast
David Grahame Hardie
@en
David Grahame Hardie
@es
David Grahame Hardie
@nl
P106
P1153
24373207900
P21
P31
P496
0000-0002-8373-7379