Rho-associated kinases in tumorigenesis: re-considering ROCK inhibition for cancer therapy
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Intravital imaging reveals new ancillary mechanisms co-opted by cancer cells to drive tumor progressionRho, ROCK and actomyosin contractility in metastasis as drug targetsNovel Insights into the Roles of Rho Kinase in CancerRho-associated kinase signalling and the cancer microenvironment: novel biological implications and therapeutic opportunitiesThe double face of Morgana in tumorigenesisMicroRNAs and Potential Targets in Osteosarcoma: ReviewApproaches of targeting Rho GTPases in cancer drug discoveryRho guanine nucleotide exchange factors: regulators of Rho GTPase activity in development and diseaseThe functional sites of miRNAs and lncRNAs in gastric carcinogenesisThe cleaved FAS ligand activates the Na(+)/H(+) exchanger NHE1 through Akt/ROCK1 to stimulate cell motilityThe RhoA-ROCK pathway in the regulation of T and B cell responsesROCK1 deficiency enhances protective effects of antioxidants against apoptosis and cell detachmentRhoC Is an Unexpected Target of RhoGDI2 in Prevention of Lung Colonization of Bladder Cancer.RNAi screens for Rho GTPase regulators of cell shape and YAP/TAZ localisation in triple negative breast cancer.Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression.miR-150 is downregulated in osteosarcoma and suppresses cell proliferation, migration and invasion by targeting ROCK1.Probing cell traction forces in confined microenvironments.APC/CCdh1-Rock2 pathway controls dendritic integrity and memory.Aurora A orchestrates entosis by regulating a dynamic MCAK-TIP150 interactionThe Rho-kinase inhibitor HA-1077 suppresses proliferation/migration and induces apoptosis of urothelial cancer cells.Rho kinase proteins display aberrant upregulation in vascular tumors and contribute to vascular tumor growth.Rho-associated coiled-coil containing kinases (ROCK): structure, regulation, and functions.Ser1333 phosphorylation indicates ROCKI activation.RNA-Seq of single prostate CTCs implicates noncanonical Wnt signaling in antiandrogen resistance.ROCK1 as a novel prognostic marker in vulvar cancerRHOA inactivation enhances Wnt signalling and promotes colorectal cancer.Movers and shakers: cell cytoskeleton in cancer metastasis.ROCK1 is a potential combinatorial drug target for BRAF mutant melanomaFHOD1, a formin upregulated in epithelial-mesenchymal transition, participates in cancer cell migration and invasion.RhoA GTPase-induced ocular hypertension in a rodent model is associated with increased fibrogenic activity in the trabecular meshwork.An mDia2/ROCK signaling axis regulates invasive egress from epithelial ovarian cancer spheroids.Immunohistochemical evaluation of ROCK activation in invasive breast cancerROCK inhibition enhances microRNA function by promoting deadenylation of targeted mRNAs via increasing PAIP2 expressionIL-4 Causes Hyperpermeability of Vascular Endothelial Cells through Wnt5A Signaling.Myotonic dystrophy kinase-related Cdc42-binding kinases (MRCK), the ROCK-like effectors of Cdc42 and Rac1.The dynamics of Rho GTPase signaling and implications for targeting cancer and the tumor microenvironment.A peptide that inhibits function of Myristoylated Alanine-Rich C Kinase Substrate (MARCKS) reduces lung cancer metastasis.Matrix rigidity differentially regulates invadopodia activity through ROCK1 and ROCK2.In Drosophila, RhoGEF2 cooperates with activated Ras in tumorigenesis through a pathway involving Rho1-Rok-Myosin-II and JNK signallingDissecting the roles of ROCK isoforms in stress-induced cell detachment.
P2860
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P2860
Rho-associated kinases in tumorigenesis: re-considering ROCK inhibition for cancer therapy
description
2012 nî lūn-bûn
@nan
2012 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Rho-associated kinases in tumo ...... inhibition for cancer therapy
@ast
Rho-associated kinases in tumo ...... inhibition for cancer therapy
@en
Rho-associated kinases in tumo ...... inhibition for cancer therapy
@nl
type
label
Rho-associated kinases in tumo ...... inhibition for cancer therapy
@ast
Rho-associated kinases in tumo ...... inhibition for cancer therapy
@en
Rho-associated kinases in tumo ...... inhibition for cancer therapy
@nl
prefLabel
Rho-associated kinases in tumo ...... inhibition for cancer therapy
@ast
Rho-associated kinases in tumo ...... inhibition for cancer therapy
@en
Rho-associated kinases in tumo ...... inhibition for cancer therapy
@nl
P2860
P3181
P356
P1433
P1476
Rho-associated kinases in tumo ...... inhibition for cancer therapy
@en
P2860
P3181
P356
10.1038/EMBOR.2012.127
P407
P577
2012-10-01T00:00:00Z