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New target for inhibition of bacterial RNA polymerase: 'switch region'

New target for inhibition of bacterial RNA polymerase: 'switch region'

http://www.wikidata.org/entity/Q24634933

about

GE23077 binds to the RNA polymerase 'i' and 'i+1' sites and prevents the binding of initiating nucleotides Opening and closing of the bacterial RNA polymerase clamp Antibiotics from predatory bacteria Recent advances in the understanding of antibiotic resistance in Clostridium difficile infection Transcription inhibition by the depsipeptide antibiotic salinamide A Bacterial RNA Polymerase-DNA Interaction-The Driving Force of Gene Expression and the Target for Drug Action Assembly and clustering of natural antibiotics guides target identification Conventional and alternative treatment approaches for Clostridium difficile infection Antibacterial Nucleoside-Analog Inhibitor of Bacterial RNA Polymerase C-terminal domain swapping of SSB changes the size of the ssDNA binding site Antibiotics and bacterial resistance in the 21st century.Structural Basis of Mycobacterium tuberculosis Transcription and Transcription Inhibition.Structural Basis of Transcription Inhibition by CBR Hydroxamidines and CBR Pyrazoles.Characterizations of clinical isolates of clostridium difficile by toxin genotypes and by susceptibility to 12 antimicrobial agents, including fidaxomicin (OPT-80) and rifaximin: a multicenter study in Taiwan Characterization of flavonol inhibition of DnaB helicase: real-time monitoring, structural modeling, and proposed mechanism.Bacterial Transcription as a Target for Antibacterial Drug Development.TFE and Spt4/5 open and close the RNA polymerase clamp during the transcription cycle Emerging therapies for Clostridium difficile infection - focus on fidaxomicin.Repression of RNA polymerase by the archaeo-viral regulator ORF145/RIP.Investigations of the mode of action and resistance development of cadazolid, a new antibiotic for treatment of Clostridium difficile infections.Fidaxomicin in Clostridium difficile infection: latest evidence and clinical guidance.CBR antimicrobials alter coupling between the bridge helix and the β subunit in RNA polymerase.Archaeology of RNA polymerase: factor swapping during the transcription cycle.Fidaxomicin for treatment of clostridium difficile-associated diarrhea and its potential role for prophylaxis.An in silico structure-based approach to anti-infective drug discovery.Antibiotics from myxobacteria.Challenges and future prospects of antibiotic therapy: from peptides to phages utilization.Antibacterials Developed to Target a Single Organism: Mechanisms and Frequencies of Reduced Susceptibility to the Novel Anti-Clostridium difficile Compounds Fidaxomicin and LFF571.Natural products from myxobacteria: novel metabolites and bioactivities.Bluegenics: Bioactive Natural Products of Medicinal Relevance and Approaches to Their Diversification.rRNA (rrn) operon-engineered Bacillus subtilis as a feasible test organism for antibiotic discovery RNA polymerase motions during promoter melting.Frequency, spectrum, and nonzero fitness costs of resistance to myxopyronin in Staphylococcus aureus.Advanced mutasynthesis studies on the natural α-pyrone antibiotic myxopyronin from Myxococcus fulvus.Salinamide F, new depsipeptide antibiotic and inhibitor of bacterial RNA polymerase from a marine-derived Streptomyces sp.A dual switch controls bacterial enhancer-dependent transcription.X-ray crystal structures of Escherichia coli RNA polymerase with switch region binding inhibitors enable rational design of squaramides with an improved fraction unbound to human plasma protein.Novel rapidly diversifiable antimicrobial RNA polymerase switch region inhibitors with confirmed mode of action in Haemophilus influenzae.Mutations in RNA Polymerase Bridge Helix and Switch Regions Affect Active-Site Networks and Transcript-Assisted Hydrolysis.Synthesis and evaluation of novel analogues of ripostatins.

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P2860

New target for inhibition of bacterial RNA polymerase: 'switch region'

http://www.wikidata.org/entity/Q24634933

description

2011 nî lūn-bûn

@nan

2011 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

@zh-hant

2011年論文

@zh-hk

2011年論文

@zh-mo

2011年論文

@zh-tw

2011年论文

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name

New target for inhibition of bacterial RNA polymerase: 'switch region'

@ast

New target for inhibition of bacterial RNA polymerase: 'switch region'

@en

New target for inhibition of bacterial RNA polymerase: 'switch region'

@nl

type

label

New target for inhibition of bacterial RNA polymerase: 'switch region'

@ast

New target for inhibition of bacterial RNA polymerase: 'switch region'

@en

New target for inhibition of bacterial RNA polymerase: 'switch region'

@nl

prefLabel

New target for inhibition of bacterial RNA polymerase: 'switch region'

@ast

New target for inhibition of bacterial RNA polymerase: 'switch region'

@en

New target for inhibition of bacterial RNA polymerase: 'switch region'

@nl

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J.MIB.2011.07.030

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Current Opinion in Microbiology

P1476

New target for inhibition of bacterial RNA polymerase: 'switch region'

@en

P2093

Aashish Srivastava

http://www.w3.org/2001/XMLSchema#string

Alex Zozula

http://www.w3.org/2001/XMLSchema#string

Anirban Chakraborty

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Cai Xin

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David Degen

http://www.w3.org/2001/XMLSchema#string

Herbert Irschik

http://www.w3.org/2001/XMLSchema#string

Jayanta Mukhopadhyay

http://www.w3.org/2001/XMLSchema#string

Juan Shen

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Meliza Talaue

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Nancy Connell

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P2860

Biological cost of rifampin resistance from the perspective of Staphylococcus aureus

Structures of RNA polymerase-antibiotic complexes

The RNA polymerase "switch region" is a target for inhibitors

Transcription inactivation through local refolding of the RNA polymerase structure

Structural mechanism for rifampicin inhibition of bacterial rna polymerase

Structural basis of transcription: RNA polymerase II at 2.8 angstrom resolution

Structural basis for transcription elongation by bacterial RNA polymerase

Role of individual drugs in the chemotherapy of tuberculosis

Rifamycin-mode of action, resistance, and biosynthesis

Microplate alamar blue assay versus BACTEC 460 system for high-throughput screening of compounds against Mycobacterium tuberculosis and Mycobacterium avium

P304

532-43

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scholarly article

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2602857

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10.1016/J.MIB.2011.07.030

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P433

5

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14

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Richard H. Ebright

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2011-10-01T00:00:00Z

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51591018

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21862392

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3196380

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