CBR antimicrobials alter coupling between the bridge helix and the β subunit in RNA polymerase.

CBR antimicrobials alter coupling between the bridge helix and the β subunit in RNA polymerase.

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http://www.wikidata.org/entity/Q37646637
Bacterial RNA Polymerase-DNA Interaction-The Driving Force of Gene Expression and the Target for Drug ActionRNA polymerase pausing and nascent-RNA structure formation are linked through clamp-domain movementTrigger-helix folding pathway and SI3 mediate catalysis and hairpin-stabilized pausing by Escherichia coli RNA polymerase.Structural Basis of Transcription Inhibition by CBR Hydroxamidines and CBR Pyrazoles.CBR antimicrobials inhibit RNA polymerase via at least two bridge-helix cap-mediated effects on nucleotide addition.Bacterial Transcription as a Target for Antibacterial Drug Development.Lineage-specific variations in the trigger loop modulate RNA proofreading by bacterial RNA polymerases.New insights into the bacterial RNA polymerase inhibitor CBR703 as a starting point for optimization as an anti-infective agent.NusG inhibits RNA polymerase backtracking by stabilizing the minimal transcription bubbleExperimental evolution of diverse Escherichia coli metabolic mutants identifies genetic loci for convergent adaptation of growth rate.The transcription-repair coupling factor Mfd associates with RNA polymerase in the absence of exogenous damage.Active site closure stabilizes the backtracked state of RNA polymerase
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CBR antimicrobials alter coupling between the bridge helix and the β subunit in RNA polymerase.

Item
http://www.wikidata.org/entity/Q37646637
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 06 March 2014
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vedecký článok
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vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
CBR antimicrobials alter coupl ...... e β subunit in RNA polymerase.
@en
CBR antimicrobials alter coupl ...... e β subunit in RNA polymerase.
@nl
type
label
CBR antimicrobials alter coupl ...... e β subunit in RNA polymerase.
@en
CBR antimicrobials alter coupl ...... e β subunit in RNA polymerase.
@nl
prefLabel
CBR antimicrobials alter coupl ...... e β subunit in RNA polymerase.
@en
CBR antimicrobials alter coupl ...... e β subunit in RNA polymerase.
@nl
P1433
P1476
P2093
P2860
P2888
P304
P31
P356
P407
P478
P50
P577
P5875
P698
P932
P356
P1433
P1476
CBR antimicrobials alter coupl ...... he β subunit in RNA polymerase
@en
P2093
P2860
P2888
P304
P31
P356
P407
P478
P50
P577
P5875
P698
P932