Two translocating hydrophilic segments of a nascent chain span the ER membrane during multispanning protein topogenesis
about
Mechanisms for quality control of misfolded transmembrane proteinsConformational transition of Sec machinery inferred from bacterial SecYE structuresYos9p and Hrd1p mediate ER retention of misfolded proteins for ER-associated degradation.Lipid-dependent generation of dual topology for a membrane protein.Cellular mechanisms of membrane protein folding.Lipids and topological rules governing membrane protein assembly.Positive charges of translocating polypeptide chain retrieve an upstream marginal hydrophobic segment from the endoplasmic reticulum lumen to the translocon.Role of human sec63 in modulating the steady-state levels of multi-spanning membrane proteins.Lipid-dependent membrane protein topogenesis.Signal anchor sequence provides motive force for polypeptide chain translocation through the endoplasmic reticulum membrane.Stepwise insertion and inversion of a type II signal anchor sequence in the ribosome-Sec61 translocon complex.Transmembrane segments of nascent polytopic membrane proteins control cytosol/ER targeting during membrane integrationMarginally hydrophobic transmembrane α-helices shaping membrane protein folding.The Ribosome-Sec61 Translocon Complex Forms a Cytosolically Restricted Environment for Early Polytopic Membrane Protein Folding.To flip or not to flip: lipid-protein charge interactions are a determinant of final membrane protein topology.In vitro reconstitution of lipid-dependent dual topology and postassembly topological switching of a membrane protein.The expanding role of the ER translocon in membrane protein folding.Sequence-specific retention and regulated integration of a nascent membrane protein by the endoplasmic reticulum Sec61 translocon.Transmembrane segments form tertiary hairpins in the folding vestibule of the ribosome.Membrane protein integration into the endoplasmic reticulum.Membrane protein TM segments are retained at the translocon during integration until the nascent chain cues FRET-detected release into bulk lipid.Visualization of distinct entities of the SecYEG translocon during translocation and integration of bacterial proteinsEnvironmental transition of signal-anchor sequences during membrane insertion via the endoplasmic reticulum translocon.Membrane translocation of lumenal domains of membrane proteins powered by downstream transmembrane sequences.Acrobatic flexibility of the translocon.
P2860
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P2860
Two translocating hydrophilic segments of a nascent chain span the ER membrane during multispanning protein topogenesis
description
2007 nî lūn-bûn
@nan
2007 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Two translocating hydrophilic ...... tispanning protein topogenesis
@ast
Two translocating hydrophilic ...... tispanning protein topogenesis
@en
Two translocating hydrophilic ...... tispanning protein topogenesis
@nl
type
label
Two translocating hydrophilic ...... tispanning protein topogenesis
@ast
Two translocating hydrophilic ...... tispanning protein topogenesis
@en
Two translocating hydrophilic ...... tispanning protein topogenesis
@nl
prefLabel
Two translocating hydrophilic ...... tispanning protein topogenesis
@ast
Two translocating hydrophilic ...... tispanning protein topogenesis
@en
Two translocating hydrophilic ...... tispanning protein topogenesis
@nl
P2093
P2860
P356
P1476
Two translocating hydrophilic ...... tispanning protein topogenesis
@en
P2093
Fumiko Morimoto
Masao Sakaguchi
Yuichiro Kida
P2860
P304
P356
10.1083/JCB.200707050
P407
P577
2007-12-31T00:00:00Z