Aberrant expression of nucleostemin activates p53 and induces cell cycle arrest via inhibition of MDM2 - Wikidata - wikimedia - TriplyDB

Aberrant expression of nucleostemin activates p53 and induces cell cycle arrest via inhibition of MDM2

Aberrant expression of nucleostemin activates p53 and induces cell cycle arrest via inhibition of MDM2

http://www.wikidata.org/entity/Q24646511

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Positive regulation of p53 stability and activity by the deubiquitinating enzyme Otubain 1 GNL3L depletion destabilizes MDM2 and induces p53-dependent G2/M arrest MYBBP1A suppresses breast cancer tumorigenesis by enhancing the p53 dependent anoikis A newly identified Pirh2 substrate SCYL1-BP1 can bind to MDM2 and accelerate MDM2 self-ubiquitination Guarding the 'translation apparatus': defective ribosome biogenesis and the p53 signaling pathway Balancing self-renewal against genome preservation in stem cells: How do they manage to have the cake and eat it too?Nucleolar stress is an early response to myocardial damage involving nucleolar proteins nucleostemin and nucleophosmin An ARF-independent c-MYC-activated tumor suppression pathway mediated by ribosomal protein-Mdm2 Interaction A strategy for full interrogation of prognostic gene expression patterns: exploring the biology of diffuse large B cell lymphoma Forced expression of Nanog or Esrrb preserves the ESC status in the absence of nucleostemin expression Regulation of the MDM2-P53 pathway and tumor growth by PICT1 via nucleolar RPL11.Nucleolar protein GLTSCR2 stabilizes p53 in response to ribosomal stresses Therapeutic considerations for Mdm2: not just a one trick pony The dynamics of the alternatively spliced NOL7 gene products and role in nucleolar architecture Nucleostemin-like 1 is required for embryogenesis and leaf development in Arabidopsis.A nucleostemin-like GTPase required for normal apical and floral meristem development in Arabidopsis.The nucleolar GTPase nucleostemin-like 1 plays a role in plant growth and senescence by modulating ribosome biogenesis.A transcription factor map as revealed by a genome-wide gene expression analysis of whole-blood mRNA transcriptome in multiple sclerosis.Ribosomal protein L11 associates with c-Myc at 5 S rRNA and tRNA genes and regulates their expression Significance of immunohistochemistry in breast cancer The Mdm2-p53 relationship evolves: Mdm2 swings both ways as an oncogene and a tumor suppressor.Role of the nucleolus in neurodegenerative diseases with particular reference to the retina: a review.Perturbation of 60 S ribosomal biogenesis results in ribosomal protein L5- and L11-dependent p53 activation MDM2 mediates nonproteolytic polyubiquitylation of the DEAD-Box RNA helicase DDX24 An off-target nucleostemin RNAi inhibits growth in human glioblastoma-derived cancer stem cells Overexpression of SCYL1-BP1 stabilizes functional p53 by suppressing MDM2-mediated ubiquitination Turning a new page on nucleostemin and self-renewal.Nucleolar stress with and without p53.Essential role of the cancer stem/progenitor cell marker nucleostemin for indole-3-carbinol anti-proliferative responsiveness in human breast cancer cells.Crucial role of TSC-22 in preventing the proteasomal degradation of p53 in cervical cancer The role of IMP dehydrogenase 2 in Inauhzin-induced ribosomal stress.Nucleostemin stabilizes ARF by inhibiting the ubiquitin ligase ULF.Ribosomal proteins and human diseases: pathogenesis, molecular mechanisms, and therapeutic implications Ribosomal proteins: functions beyond the ribosome PAK1IP1, a ribosomal stress-induced nucleolar protein, regulates cell proliferation via the p53-MDM2 loop.Nucleostemin rejuvenates cardiac progenitor cells and antagonizes myocardial aging.MDM2 promotes invasion and metastasis in invasive ductal breast carcinoma by inducing matrix metalloproteinase-9.Interplay between ribosomal protein S27a and MDM2 protein in p53 activation in response to ribosomal stress.Cyclopentenyl cytosine induces senescence in breast cancer cells through the nucleolar stress response and activation of p53.Nucleostemin expression in invasive breast cancer.

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P2860

Aberrant expression of nucleostemin activates p53 and induces cell cycle arrest via inhibition of MDM2

http://www.wikidata.org/entity/Q24646511

description

2008 nî lūn-bûn

@nan

2008 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

2008 թվականի հուլիսին հրատարակված գիտական հոդված

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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name

Aberrant expression of nucleos ...... arrest via inhibition of MDM2

@ast

Aberrant expression of nucleos ...... arrest via inhibition of MDM2

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Aberrant expression of nucleos ...... arrest via inhibition of MDM2

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type

label

Aberrant expression of nucleos ...... arrest via inhibition of MDM2

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Aberrant expression of nucleos ...... arrest via inhibition of MDM2

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Aberrant expression of nucleos ...... arrest via inhibition of MDM2

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prefLabel

Aberrant expression of nucleos ...... arrest via inhibition of MDM2

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Aberrant expression of nucleos ...... arrest via inhibition of MDM2

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Aberrant expression of nucleos ...... arrest via inhibition of MDM2

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Molecular and Cellular Biology

P1476

Aberrant expression of nucleos ...... arrest via inhibition of MDM2

@en

P2093

Hua Lu

http://www.w3.org/2001/XMLSchema#string

Mu-Shui Dai

http://www.w3.org/2001/XMLSchema#string

Xiao-Xin Sun

http://www.w3.org/2001/XMLSchema#string

P2860

Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53

Nucleolar protein NPM interacts with HDM2 and protects tumor suppressor protein p53 from HDM2-mediated degradation

Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function

Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

Inhibition of c-Myc activity by ribosomal protein L11

MDMX regulation of p53 response to ribosomal stress

Mdm2 promotes the rapid degradation of p53

Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

An essential function of the extreme C-terminus of MDM2 can be provided by MDMX

A nonribosomal landscape in the nucleolus revealed by the stem cell protein nucleostemin

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4365-76

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scholarly article

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10.1128/MCB.01662-07

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13

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28

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18426907

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2447154

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