Tyrosine phosphorylation sites at amino acids 239 and 240 of Shc are involved in epidermal growth factor-induced mitogenic signaling that is distinct from Ras/mitogen-activated protein kinase activation

Tyrosine phosphorylation sites at amino acids 239 and 240 of Shc are involved in epidermal growth factor-induced mitogenic signaling that is distinct from Ras/mitogen-activated protein kinase activation

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http://www.wikidata.org/entity/Q24646756

Q24646756

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Molecular basis of signaling specificity of insulin and IGF receptors: neglected corners and recent advances The adaptor protein Tom1L1 is a negative regulator of Src mitogenic signaling induced by growth factors Epidermal growth factor receptor and the adaptor protein p52Shc are specific substrates of T-cell protein tyrosine phosphatase.SU6656, a selective src family kinase inhibitor, used to probe growth factor signaling Biological activity of the thyroid TRK-T3 oncogene requires signalling through Shc Non-redundant signal transduction of interleukin-6-type cytokines. The adapter protein Shc is specifically recruited to rhe oncostatin M receptor Signaling via Shc family adapter proteins Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules Grb2 forms an inducible protein complex with CD28 through a Src homology 3 domain-proline interaction Roles of Lck, Syk and ZAP-70 tyrosine kinases in TCR-mediated phosphorylation of the adapter protein Shc Role of tyrosine residues and protein interaction domains of SHC adaptor in VEGF receptor 3 signaling ShcA and Grb2 mediate polyoma middle T antigen-induced endothelial transformation and Gab1 tyrosine phosphorylation.ShcA tyrosine phosphorylation sites can replace ShcA binding in signalling by middle T-antigen The PTB domain of ShcA couples receptor activation to the cytoskeletal regulator IQGAP1 Cloning and characterization of mPAL, a novel Shc SH2 domain-binding protein expressed in proliferating cells Analysis of a Shc family adaptor protein, ShcD/Shc4, that associates with muscle-specific kinase Distinct signaling functions for Shc isoforms in the heart Distinct tyrosine autophosphorylation sites negatively and positively modulate neu-mediated transformation Identification of receptor-tyrosine-kinase-signaling target genes reveals receptor-specific activities and pathway branchpoints during Drosophila development Crk adaptor protein-induced phosphorylation of Gab1 on tyrosine 307 via Src is important for organization of focal adhesions and enhanced cell migration.Pore-forming Staphylococcus aureus alpha-toxin triggers epidermal growth factor receptor-dependent proliferation.ShcA regulates thymocyte proliferation through specific transcription factors and a c-Abl-dependent signaling axis.Role of Shc in T-cell development and function.Evidence for a requirement for both phospholipid and phosphotyrosine binding via the Shc phosphotyrosine-binding domain in vivo Grb2 SH2 domain-binding peptide analogs as potential anticancer agents.Signal transduction in mammary tumorigenesis: a transgenic perspective.Accelerated mammary tumor development in mutant polyomavirus middle T transgenic mice expressing elevated levels of either the Shc or Grb2 adapter protein.Impaired TrkB-mediated ERK1/2 activation in huntington disease knock-in striatal cells involves reduced p52/p46 Shc expression Grb2 and Shc adapter proteins play distinct roles in Neu (ErbB-2)-induced mammary tumorigenesis: implications for human breast cancer p66Shc longevity protein regulates the proliferation of human ovarian cancer cells Genetic evidence for Shc requirement in TCR-induced c-Rel nuclear translocation and IL-2 expression.Quantitative in vivo fluorescence cross-correlation analyses highlight the importance of competitive effects in the regulation of protein-protein interactions Platelet-derived growth factor (PDGF)-induced tyrosine phosphorylation of the low density lipoprotein receptor-related protein (LRP). Evidence for integrated co-receptor function betwenn LRP and the PDGF.The relative role of ErbB1-4 receptor tyrosine kinases in radiation signal transduction responses of human carcinoma cells.Unique role of SNT-2/FRS2beta/FRS3 docking/adaptor protein for negative regulation in EGF receptor tyrosine kinase signaling pathways.Diverse role of LDL receptor-related protein in the clearance of proteases and in signaling.The silence of p66(Shc) in HCT8 cells inhibits the viability via PI3K/AKT/Mdm-2/p53 signaling pathway.Integrin signaling in malignant melanoma.Bifurcation of cell migratory and proliferative signaling by the adaptor protein Shc.The Shc adaptor protein is critical for VEGF induction by Met/HGF and ErbB2 receptors and for early onset of tumor angiogenesis

P2860

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P2860

Tyrosine phosphorylation sites at amino acids 239 and 240 of Shc are involved in epidermal growth factor-induced mitogenic signaling that is distinct from Ras/mitogen-activated protein kinase activation

Item

http://www.wikidata.org/entity/Q24646756

description

1997 nî lūn-bûn

@nan

1997 թուականի Ապրիլին հրատարակուած գիտական յօդուած

@hyw

1997 թվականի ապրիլին հրատարակված գիտական հոդված

@hy

1997年の論文

@ja

1997年論文

@yue

1997年論文

@zh-hant

1997年論文

@zh-hk

1997年論文

@zh-mo

1997年論文

@zh-tw

1997年论文

@wuu