Disruption of the neurexin 1 gene is associated with schizophrenia - Wikidata - wikimedia - TriplyDB

Disruption of the neurexin 1 gene is associated with schizophrenia

Disruption of the neurexin 1 gene is associated with schizophrenia

http://www.wikidata.org/entity/Q24647095

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Expanding the clinical spectrum associated with defects in CNTNAP2 and NRXN1 Evolution in health and medicine Sackler colloquium: Comparative genomics of autism and schizophrenia Truncating mutations in NRXN2 and NRXN1 in autism spectrum disorders and schizophrenia Rare deletions at the neurexin 3 locus in autism spectrum disorder Analysis of copy number variation in Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals CNTNAP2 and NRXN1 are mutated in autosomal-recessive Pitt-Hopkins-like mental retardation and determine the level of a common synaptic protein in Drosophila Mouse neurexin-1alpha deletion causes correlated electrophysiological and behavioral changes consistent with cognitive impairments.CNV analysis in a large schizophrenia sample implicates deletions at 16p12.1 and SLC1A1 and duplications at 1p36.33 and CGNL1 SAM68 regulates neuronal activity-dependent alternative splicing of neurexin-1 Rate of de novo mutations and the importance of father's age to disease risk Microduplications of 16p11.2 are associated with schizophrenia A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB Neurexin 1 (NRXN1) deletions in schizophrenia Neurexins physically and functionally interact with GABA(A) receptors An autism-associated point mutation in the neuroligin cytoplasmic tail selectively impairs AMPA receptor-mediated synaptic transmission in hippocampus High affinity neurexin binding to cell adhesion G-protein-coupled receptor CIRL1/latrophilin-1 produces an intercellular adhesion complex RIM1alpha and interacting proteins involved in presynaptic plasticity mediate prepulse inhibition and additional behaviors linked to schizophrenia LRRTM2 functions as a neurexin ligand in promoting excitatory synapse formation The dysconnection hypothesis (2016)Genetics and genomics of psychiatric disease Modeling psychiatric disorders for developing effective treatments Two patients walk into a clinic...a genomics perspective on the future of schizophrenia Molecular characterization of NRXN1 deletions from 19,263 clinical microarray cases identifies exons important for neurodevelopmental disease expression.The Crystal Structure of the α-Neurexin-1 Extracellular Region Reveals a Hinge Point for Mediating Synaptic Adhesion and Function Genetic aspects of autism spectrum disorders: insights from animal models CNVs in neuropsychiatric disorders Array-based technology and recommendations for utilization in medical genetics practice for detection of chromosomal abnormalities Copy number variants in schizophrenia: confirmation of five previous findings and new evidence for 3q29 microdeletions and VIPR2 duplications Deleterious GRM1 mutations in schizophrenia LRRTM1-deficient mice show a rare phenotype of avoiding small enclosures--a tentative mouse model for claustrophobia-like behaviour.Genetic targeting of NRXN2 in mice unveils role in excitatory cortical synapse function and social behaviors The Danish 22q11 research initiative Neurexin-1 and frontal lobe white matter: an overlapping intermediate phenotype for schizophrenia and autism spectrum disorders Hotspots of large rare deletions in the human genome The role of genetics in the etiology of schizophrenia Developmental delays and reduced pup ultrasonic vocalizations but normal sociability in mice lacking the postsynaptic cell adhesion protein neuroligin2.Modulation of cell adhesion systems by prenatal nicotine exposure in limbic brain regions of adolescent female rats.The Long and the Short of it: Gene and Environment Interactions During Early Cortical Development and Consequences for Long-Term Neurological Disease.New frontiers in animal research of psychiatric illness Genetic regulation of Nrxn1 [corrected] expression: an integrative cross-species analysis of schizophrenia candidate genes

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P2860

Disruption of the neurexin 1 gene is associated with schizophrenia

http://www.wikidata.org/entity/Q24647095

description

2009 nî lūn-bûn

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2009 թուականի Մարտին հրատարակուած գիտական յօդուած

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2009 թվականի մարտին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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Disruption of the neurexin 1 gene is associated with schizophrenia

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Disruption of the neurexin 1 gene is associated with schizophrenia

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Disruption of the neurexin 1 gene is associated with schizophrenia

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type

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Disruption of the neurexin 1 gene is associated with schizophrenia

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Disruption of the neurexin 1 gene is associated with schizophrenia

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Disruption of the neurexin 1 gene is associated with schizophrenia

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prefLabel

Disruption of the neurexin 1 gene is associated with schizophrenia

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Disruption of the neurexin 1 gene is associated with schizophrenia

@en

Disruption of the neurexin 1 gene is associated with schizophrenia

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Human Molecular Genetics

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Andres Ingason

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Annette M Hartmann

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Arnaldur Gylfason

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Caroline Crombie

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Chiara Bonetto

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Chiara Sabatti

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David A Collier

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Evangelos Vassos

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Gillian Fraser

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P2860

Genomic disorders: molecular mechanisms for rearrangements and conveyed phenotypes

Rare chromosomal deletions and duplications increase risk of schizophrenia

A patient with vertebral, cognitive and behavioural abnormalities and a de novo deletion of NRXN1alpha

High frequency of neurexin 1beta signal peptide structural variants in patients with autism

Strong association of de novo copy number mutations with autism

Disruption of neurexin 1 associated with autism spectrum disorder.

Large recurrent microdeletions associated with schizophrenia

Structural variation of chromosomes in autism spectrum disorder

Global variation in copy number in the human genome

A unified genetic theory for sporadic and inherited autism

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10.1093/HMG/DDN351

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5

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18

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Hans-Jürgen Möller

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Leena Peltonen-Palotie

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Jouko Lönnqvist

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2009-03-01T00:00:00Z

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