Mouse neurexin-1alpha deletion causes correlated electrophysiological and behavioral changes consistent with cognitive impairments.
about
Genetic-background modulation of core and variable autistic-like symptoms in Fmr1 knock-out mice.Truncating mutations in NRXN2 and NRXN1 in autism spectrum disorders and schizophreniaRare deletions at the neurexin 3 locus in autism spectrum disorderCalsyntenins function as synaptogenic adhesion molecules in concert with neurexinsShank3 mutant mice display autistic-like behaviours and striatal dysfunctionAutism-associated neuroligin-3 mutations commonly disrupt tonic endocannabinoid signalingNeurexins and neuroligins: recent insights from invertebratesThe structure of neurexin 1α reveals features promoting a role as synaptic organizerBehavioral and cerebellar transmission deficits in mice lacking the autism-linked gene islet brain-2Autism-associated neuroligin-3 mutations commonly impair striatal circuits to boost repetitive behaviors.Region-specific deletions of RIM1 reproduce a subset of global RIM1α(-/-) phenotypesNeurexins physically and functionally interact with GABA(A) receptorsSynaptic cell adhesionAn autism-associated point mutation in the neuroligin cytoplasmic tail selectively impairs AMPA receptor-mediated synaptic transmission in hippocampusAutism-linked neuroligin-3 R451C mutation differentially alters hippocampal and cortical synaptic functionRIM1alpha and interacting proteins involved in presynaptic plasticity mediate prepulse inhibition and additional behaviors linked to schizophreniaNeuroligin-1 deletion results in impaired spatial memory and increased repetitive behavior.Clinical and Neurobiological Relevance of Current Animal Models of Autism Spectrum Disorders.Mouse Genetic Models of Human Brain DisordersAutism Spectrum Disorders and Drug Addiction: Common Pathways, Common Molecules, Distinct Disorders?Behavioral phenotypes of genetic mouse models of autism.Modeling psychiatric disorders for developing effective treatmentsExcitatory/Inhibitory Balance and Circuit Homeostasis in Autism Spectrum DisordersFollowing the genes: a framework for animal modeling of psychiatric disordersThe molecular basis of cognitive deficits in pervasive developmental disordersCNVs: harbingers of a rare variant revolution in psychiatric geneticsBehavioral and Neuroanatomical Phenotypes in Mouse Models of AutismNMDA receptor agonists reverse impaired psychomotor and cognitive functions associated with hippocampal Hbegf-deficiency in miceMissense mutation in DISC1 C-terminal coiled-coil has GSK3β signaling and sex-dependent behavioral effects in miceNegative allosteric modulation of the mGluR5 receptor reduces repetitive behaviors and rescues social deficits in mouse models of autism.Heterozygous deletion of α-neurexin I or α-neurexin II results in behaviors relevant to autism and schizophrenia.Deletion of JMJD2B in neurons leads to defective spine maturation, hyperactive behavior and memory deficits in mouseAdvancing the understanding of autism disease mechanisms through geneticsNeuronal mechanisms and circuits underlying repetitive behaviors in mouse models of autism spectrum disorderA Subset of Autism-Associated Genes Regulate the Structural Stability of Neurons.Modeling a model: Mouse genetics, 22q11.2 Deletion Syndrome, and disorders of cortical circuit developmentCommon mechanisms of excitatory and inhibitory imbalance in schizophrenia and autism spectrum disordersDeletion of α-neurexin II results in autism-related behaviors in miceMutations in NRXN1 in a family multiply affected with brain disorders: NRXN1 mutations and brain disordersCopy number variants in schizophrenia: confirmation of five previous findings and new evidence for 3q29 microdeletions and VIPR2 duplications
P2860
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P2860
Mouse neurexin-1alpha deletion causes correlated electrophysiological and behavioral changes consistent with cognitive impairments.
description
2009 nî lūn-bûn
@nan
2009 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Mouse neurexin-1alpha deletion ...... ent with cognitive impairments
@nl
Mouse neurexin-1alpha deletion ...... nt with cognitive impairments.
@ast
Mouse neurexin-1alpha deletion ...... nt with cognitive impairments.
@en
Mouse neurexin-1alpha deletion ...... nt with cognitive impairments.
@en-gb
type
label
Mouse neurexin-1alpha deletion ...... ent with cognitive impairments
@nl
Mouse neurexin-1alpha deletion ...... nt with cognitive impairments.
@ast
Mouse neurexin-1alpha deletion ...... nt with cognitive impairments.
@en
Mouse neurexin-1alpha deletion ...... nt with cognitive impairments.
@en-gb
prefLabel
Mouse neurexin-1alpha deletion ...... ent with cognitive impairments
@nl
Mouse neurexin-1alpha deletion ...... nt with cognitive impairments.
@ast
Mouse neurexin-1alpha deletion ...... nt with cognitive impairments.
@en
Mouse neurexin-1alpha deletion ...... nt with cognitive impairments.
@en-gb
P2860
P921
P3181
P356
P1476
Mouse neurexin-1alpha deletion ...... nt with cognitive impairments.
@en
P2093
Cory A Blaiss
Mark R Etherton
P2860
P304
17998-18003
P3181
P356
10.1073/PNAS.0910297106
P407
P577
2009-10-12T00:00:00Z