The extremely slow and variable activity of dihydrofolate reductase in human liver and its implications for high folic acid intake
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Human endothelial dihydrofolate reductase low activity limits vascular tetrahydrobiopterin recyclingThe former annotated human pseudogene dihydrofolate reductase-like 1 (DHFRL1) is expressed and functionalBiomarkers of Nutrition for Development-Folate ReviewContemporary issues surrounding folic Acid fortification initiativesQueuosine deficiency in eukaryotes compromises tyrosine production through increased tetrahydrobiopterin oxidationAn active second dihydrofolate reductase enzyme is not a feature of rat and mouse, but they do have activity in their mitochondriaCeramide Synthase 6 Is a Novel Target of Methotrexate Mediating Its Antiproliferative Effect in a p53-Dependent MannerFolate MetabolismEffects of Non-Natural Amino Acid Incorporation into the Enzyme Core Region on Enzyme Structure and Function.Persistent circulating unmetabolised folic acid in a setting of liberal voluntary folic acid fortification. Implications for further mandatory fortification?Folic acid treatment normalizes NOS-dependence of vascular tone in the metabolic syndrome.Impact of folic acid fortification on global DNA methylation and one-carbon biomarkers in the Women's Health Initiative Observational Study cohortFolic acid handling by the human gut: implications for food fortification and supplementation.Unmetabolized serum folic acid and its relation to folic acid intake from diet and supplements in a nationally representative sample of adults aged > or =60 y in the United StatesA candidate gene study of folate-associated one carbon metabolism genes and colorectal cancer risk.Molecular mechanisms underlying the potentially adverse effects of folateUnmetabolized folic acid is detected in nearly all serum samples from US children, adolescents, and adultsMicroarray analysis reveals higher gestational folic Acid alters expression of genes in the cerebellum of mice offspring-a pilot study.Control of prostate cancer associated with withdrawal of a supplement containing folic acid, L-methyltetrahydrofolate and vitamin B12: a case reportCirculating unmetabolized folic Acid: relationship to folate status and effect of supplementation.Intake and Biomarkers of Folate and Risk of Cancer Morbidity in Older Adults, NHANES 1999-2002 with Medicare Linkage.The Dihydrofolate Reductase 19 bp Polymorphism Is Not Associated with Biomarkers of Folate Status in Healthy Young Adults, Irrespective of Folic Acid Intake.Risk of retinoblastoma is associated with a maternal polymorphism in dihydrofolatereductase (DHFR) and prenatal folic acid intakeDihydrofolate reductase 19-bp deletion polymorphism modifies the association of folate status with memory in a cross-sectional multi-ethnic study of adults.Folic acid supplementation during high-fat diet feeding restores AMPK activation via an AMP-LKB1-dependent mechanism.Maternal obesity disrupts the methionine cycle in baboon pregnancy.Down-regulation of dihydrofolate reductase inhibits the growth of endothelial EA.hy926 cell through induction of G1 cell cycle arrest via up-regulating p53 and p21(waf1/cip1) expression.DNA Methylation Profiling at Single-Base Resolution Reveals Gestational Folic Acid Supplementation Influences the Epigenome of Mouse Offspring Cerebellum.Efficacy of Folic Acid Supplementation in Autistic Children Participating in Structured Teaching: An Open-Label TrialThe Relationship between Folic Acid and Risk of Autism Spectrum Disorders.Human dihydrofolate reductase influences the sensitivity of the malaria parasite Plasmodium falciparum to ketotifen - A cautionary tale in screening transgenic parasites.Excess Folic Acid Increases Lipid Storage, Weight Gain, and Adipose Tissue Inflammation in High Fat Diet-Fed RatsFolic acid supplementation promotes mammary tumor progression in a rat model.Recommendations for folate intake in women: implications for public health strategies.Gene-environment interactions and epigenetic pathways in autism: the importance of one-carbon metabolism.Impact of folate supplementation on the efficacy of sulfadoxine/pyrimethamine in preventing malaria in pregnancy: the potential of 5-methyl-tetrahydrofolate.Mechanisms by which maternal obesity programs offspring for obesity: evidence from animal studies.Folate, folic acid and 5-methyltetrahydrofolate are not the same thing.The effect of diet on the intestinal epigenome.Folate supplementation reduces the side effects of methotrexate therapy for psoriasis.
P2860
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P2860
The extremely slow and variable activity of dihydrofolate reductase in human liver and its implications for high folic acid intake
description
2009 nî lūn-bûn
@nan
2009 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
The extremely slow and variabl ...... ons for high folic acid intake
@ast
The extremely slow and variabl ...... ons for high folic acid intake
@en
The extremely slow and variabl ...... ons for high folic acid intake
@nl
type
label
The extremely slow and variabl ...... ons for high folic acid intake
@ast
The extremely slow and variabl ...... ons for high folic acid intake
@en
The extremely slow and variabl ...... ons for high folic acid intake
@nl
prefLabel
The extremely slow and variabl ...... ons for high folic acid intake
@ast
The extremely slow and variabl ...... ons for high folic acid intake
@en
The extremely slow and variabl ...... ons for high folic acid intake
@nl
P2860
P3181
P356
P1476
The extremely slow and variabl ...... ons for high folic acid intake
@en
P2093
June E Ayling
Steven W Bailey
P2860
P304
P3181
P356
10.1073/PNAS.0902072106
P407
P577
2009-09-08T00:00:00Z