MDM2 regulates dihydrofolate reductase activity through monoubiquitination - Wikidata - wikimedia - TriplyDB

MDM2 regulates dihydrofolate reductase activity through monoubiquitination

MDM2 regulates dihydrofolate reductase activity through monoubiquitination

http://www.wikidata.org/entity/Q24634031

about

Mdm2 directs the ubiquitination of beta-arrestin-sequestered cAMP phosphodiesterase-4D5 The former annotated human pseudogene dihydrofolate reductase-like 1 (DHFRL1) is expressed and functional The extremely slow and variable activity of dihydrofolate reductase in human liver and its implications for high folic acid intake The unfolded protein response regulator GRP78 is a novel predictive biomarker in colorectal cancer.A Novel Interaction between TFII-I and Mdm2 with a Negative Effect on TFII-I Transcriptional Activity Mdm2 links genotoxic stress and metabolism to p53.MDM2 antagonist Nutlin-3a potentiates antitumour activity of cytotoxic drugs in sarcoma cell lines.MDM2 mediates nonproteolytic polyubiquitylation of the DEAD-Box RNA helicase DDX24 The nucleolus directly regulates p53 export and degradation Competition between sumoylation and ubiquitination of serine hydroxymethyltransferase 1 determines its nuclear localization and its accumulation in the nucleus.Structural Exploration and Conformational Transitions in MDM2 upon DHFR Interaction from Homo sapiens: A Computational Outlook for Malignancy via Epigenetic Disruption.The MDM2-p53 pathway revisited Mouse double minute 2 (MDM2) upregulates Snail expression and induces epithelial-to-mesenchymal transition in breast cancer cells in vitro and in vivo.MDM2's social network.The clinical and therapeutic uses of MDM2 and PSMA and their potential interaction in aggressive cancers.Effects of MDM2 inhibitors on vascular endothelial growth factor-mediated tumor angiogenesis in human breast cancer.MDM2 promotes cell motility and invasiveness through a RING-finger independent mechanism.E3 ubiquitin ligases in cancer and implications for therapies.Natural (and Unnatural) Small Molecules as Pharmacological Chaperones and Inhibitors in Cancer.Loss of Diacylglycerol Kinase-Ζ Inhibits Cell Proliferation and Survival in Human Gliomas.

P2860

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P2860

MDM2 regulates dihydrofolate reductase activity through monoubiquitination

http://www.wikidata.org/entity/Q24634031

description

2008 nî lūn-bûn

@nan

2008 թուականի Մայիսին հրատարակուած գիտական յօդուած

@hyw

2008 թվականի մայիսին հրատարակված գիտական հոդված

@hy

2008年の論文

@ja

2008年論文

@yue

2008年論文

@zh-hant

2008年論文

@zh-hk

2008年論文

@zh-mo

2008年論文

@zh-tw

2008年论文

@wuu

name

MDM2 regulates dihydrofolate reductase activity through monoubiquitination

@ast

MDM2 regulates dihydrofolate reductase activity through monoubiquitination

@en

MDM2 regulates dihydrofolate reductase activity through monoubiquitination

@nl

type

label

MDM2 regulates dihydrofolate reductase activity through monoubiquitination

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MDM2 regulates dihydrofolate reductase activity through monoubiquitination

@en

MDM2 regulates dihydrofolate reductase activity through monoubiquitination

@nl

prefLabel

MDM2 regulates dihydrofolate reductase activity through monoubiquitination

@ast

MDM2 regulates dihydrofolate reductase activity through monoubiquitination

@en

MDM2 regulates dihydrofolate reductase activity through monoubiquitination

@nl

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0008-5472.CAN-07-5271

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Cancer Research

P1476

MDM2 regulates dihydrofolate reductase activity through monoubiquitination

@en

P2093

B Kevin Park

http://www.w3.org/2001/XMLSchema#string

Maria Maguire

http://www.w3.org/2001/XMLSchema#string

Mark T Boyd

http://www.w3.org/2001/XMLSchema#string

Nikolina Vlatković

http://www.w3.org/2001/XMLSchema#string

Paul C Nield

http://www.w3.org/2001/XMLSchema#string

Radoslaw Polański

http://www.w3.org/2001/XMLSchema#string

Rosalind E Jenkins

http://www.w3.org/2001/XMLSchema#string

Timothy Devling

http://www.w3.org/2001/XMLSchema#string

P2860

Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53

Mdm2 promotes the rapid degradation of p53

Interaction between the retinoblastoma protein and the oncoprotein MDM2

The Mdm2 oncoprotein interacts with the cell fate regulator Numb

Regulation of p53 stability by Mdm2

Regulation of receptor fate by ubiquitination of activated beta 2-adrenergic receptor and beta-arrestin

A novel cellular protein (MTBP) binds to MDM2 and induces a G1 arrest that is suppressed by MDM2

Regulating the p53 pathway: in vitro hypotheses, in vivo veritas

Protein regulation by monoubiquitin

Overexpression of Mdm2 in mice reveals a p53-independent role for Mdm2 in tumorigenesis.

P304

3232-42

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scholarly article

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2265036

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10.1158/0008-5472.CAN-07-5271

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9

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68

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2008-05-01T00:00:00Z

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5401789

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18451149

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3536468

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