Quantitative modeling of selective lysosomal targeting for drug design
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Identification of novel functional inhibitors of acid sphingomyelinaseIn vitro and in vivo models for the study of oral delivery of nanoparticlesInhibition of acid sphingomyelinase by tricyclic antidepressants and analogonsPathways and progress in improving drug delivery through the intestinal mucosa and blood-brain barriersLysosomotropic properties of weakly basic anticancer agents promote cancer cell selectivity in vitroVisualizing chemical structure-subcellular localization relationships using fluorescent small molecules as probes of cellular transportA Clickable Analogue of Ketamine Retains NMDA Receptor Activity, Psychoactivity, and Accumulates in Neurons.Identification of drugs inducing phospholipidosis by novel in vitro dataMachine vision-assisted analysis of structure-localization relationships in a combinatorial library of prospective bioimaging probes.Challenges of antibacterial discoveryLong-acting κ opioid antagonists nor-BNI, GNTI and JDTic: pharmacokinetics in mice and lipophilicityImaging the intracellular distribution of tyrosine kinase inhibitors in living cells with quantitative hyperspectral stimulated Raman scatteringMechanisms of amine accumulation in, and egress from, lysosomes.Harnessing the power of yeast to elucidate the role of sphingolipids in metabolic and signaling processes pertinent to psychiatric disorders.Repurposing Cationic Amphiphilic Antihistamines for Cancer TreatmentScreening for the drug-phospholipid interaction: correlation to phospholipidosis.Computational approaches to analyse and predict small molecule transport and distribution at cellular and subcellular levelsToward a new age of cellular pharmacokinetics in drug discovery.The subcellular distribution of small molecules: from pharmacokinetics to synthetic biologyOptimal choice of pH for toxicity and bioaccumulation studies of ionizing organic chemicals.Does transbilayer diffusion have a role in membrane transport of drugs?Uptake and localisation of small-molecule fluorescent probes in living cells: a critical appraisal of QSAR models and a case study concerning probes for DNA and RNA.Predicting small molecule fluorescent probe localization in living cells using QSAR modeling. 1. Overview and models for probes of structure, properties and function in single cells.Accounting for dissociation and photolysis: a review of the algal toxicity of triclosan.Luminescent probes for the bioimaging of small anionic species in vitro and in vivo.Ceramide and Its Related Neurochemical Networks as Targets for Some Brain Disorder Therapies.Rapid Method To Determine Intracellular Drug Concentrations in Cellular Uptake Assays: Application to Metformin in Organic Cation Transporter 1-Transfected Human Embryonic Kidney 293 Cells.Uptake and localization mechanisms of fluorescent and colored lipid probes. 1. Physicochemistry of probe uptake and localization, and the use of QSAR models for selectivity prediction.Cells on pores: a simulation-driven analysis of transcellular small molecule transport.Selective and regulated trapping of nicotinic receptor weak base ligands and relevance to smoking cessation.Intrinsic fluorescence of the clinically approved multikinase inhibitor nintedanib reveals lysosomal sequestration as resistance mechanism in FGFR-driven lung cancer.Development of a population pharmacokinetic model characterizing the tissue distribution of azithromycin in healthy subjects.Ketamine inside neurons?Virtual Cell Based Assay simulations of intra-mitochondrial concentrations in hepatocytes and cardiomyocytes.The antidepressant fluoxetine mobilizes vesicles to the recycling pool of rat hippocampal synapses during high activity.Hydroxychloroquine: A Physiologically-Based Pharmacokinetic Model in the Context of Cancer-Related Autophagy Modulation.How active ingredient localisation in plant tissues determines the targeted pest spectrum of different chemistries.
P2860
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P2860
Quantitative modeling of selective lysosomal targeting for drug design
description
2008 nî lūn-bûn
@nan
2008 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
name
Quantitative modeling of selective lysosomal targeting for drug design
@ast
Quantitative modeling of selective lysosomal targeting for drug design
@en
Quantitative modeling of selective lysosomal targeting for drug design
@nl
type
label
Quantitative modeling of selective lysosomal targeting for drug design
@ast
Quantitative modeling of selective lysosomal targeting for drug design
@en
Quantitative modeling of selective lysosomal targeting for drug design
@nl
prefLabel
Quantitative modeling of selective lysosomal targeting for drug design
@ast
Quantitative modeling of selective lysosomal targeting for drug design
@en
Quantitative modeling of selective lysosomal targeting for drug design
@nl
P2860
P1476
Quantitative modeling of selective lysosomal targeting for drug design
@en
P2093
Gus R Rosania
Richard W Horobin
P2860
P2888
P304
P356
10.1007/S00249-008-0338-4
P407
P577
2008-10-01T00:00:00Z
P5875
P6179
1045739897