Lysosomal sequestration of amine-containing drugs: analysis and therapeutic implications.
about
Unbiased probing of the entire hepatitis C virus life cycle identifies clinical compounds that target multiple aspects of the infectionQuantitative modeling of selective lysosomal targeting for drug designAutophagy in colorectal cancer: An important switch from physiology to pathologyPathways and progress in improving drug delivery through the intestinal mucosa and blood-brain barriersProtective Roles of N-acetyl Cysteine and/or Taurine against Sumatriptan-Induced HepatotoxicitySmall molecule kinase inhibitors approved by the FDA from 2000 to 2011: a systematic review of preclinical ADME data.Simulation-based cheminformatic analysis of organelle-targeted molecules: lysosomotropic monobasic amines.Identifying the structure-activity relationship of leelamine necessary for inhibiting intracellular cholesterol transport.Intracellular trafficking as a determinant of AS-DACA cytotoxicity in rhabdomyosarcoma cells.A series of naphthalimide derivatives as intra and extracellular pH sensorsLysosomal trapping of a radiolabeled substrate of P-glycoprotein as a mechanism for signal amplification in PETMechanisms of amine accumulation in, and egress from, lysosomes.Small-molecule enhancers of autophagy modulate cellular disease phenotypes suggested by human genetics.Massive Bioaccumulation and Self-Assembly of Phenazine Compounds in Live Cells.Discerning the Chemistry in Individual Organelles with Small-Molecule Fluorescent Probes.Role of autophagy and lysosomal drug sequestration in acquired resistance to doxorubicin in MCF-7 cellsNovel analogs of D-e-MAPP and B13. Part 2: signature effects on bioactive sphingolipids.Novel analogs of D-e-MAPP and B13. Part 1: synthesis and evaluation as potential anticancer agents.Resistance to sunitinib in renal clear cell carcinoma results from sequestration in lysosomes and inhibition of the autophagic fluxTargeted polymeric therapeutic nanoparticles: design, development and clinical translationInteraction with the hERG channel and cytotoxicity of amiodarone and amiodarone analogues.Chemical principles for the design of a novel fluorescent probe with high cancer-targeting selectivity and sensitivity.Subcellular targeting: a new frontier for drug-loaded pharmaceutical nanocarriers and the concept of the magic bullet.Computational approaches to analyse and predict small molecule transport and distribution at cellular and subcellular levelsHarnessing the lysosome-dependent antitumor activity of phenothiazines in human small cell lung cancer.Peptide-mediated targeted drug delivery.Role of phosphatidylserine binding in tissue distribution of amine-containing basic compounds.Hydroxychloroquine in systemic lupus erythematosus and rheumatoid arthritis and its safety in pregnancy.Probe ADME and test hypotheses: a PATH beyond clearance in vitro-in vivo correlations in early drug discovery.Autophagy modulation: a target for cancer treatment development.Chloroquine analogues in drug discovery: new directions of uses, mechanisms of actions and toxic manifestations from malaria to multifarious diseases.A systematic analysis of physicochemical and ADME properties of all small molecule kinase inhibitors approved by US FDA from January 2001 to October 2015.Contribution of membrane trafficking perturbation to retinal toxicity.Hydroxychloroquine in systemic lupus erythematosus (SLE).Improved Targeting of Cancers with Nanotherapeutics.Pazopanib and sunitinib trigger autophagic and non-autophagic death of bladder tumour cells.The lysosomal inhibitor, chloroquine, increases cell surface BMPR-II levels and restores BMP9 signalling in endothelial cells harbouring BMPR-II mutationsAssociating in vitro target binding and in vivo CNS occupancy of serotonin reuptake inhibitors in rats: the role of free drug concentrations.Subcellular Partitioning and Intramacrophage Selectivity of Antimicrobial Compounds against Mycobacterium tuberculosis.Verapamil hepatic clearance in four preclinical rat models: towards activity-based scaling.
P2860
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P2860
Lysosomal sequestration of amine-containing drugs: analysis and therapeutic implications.
description
2007 nî lūn-bûn
@nan
2007 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Lysosomal sequestration of amine-containing drugs: analysis and therapeutic implications.
@ast
Lysosomal sequestration of amine-containing drugs: analysis and therapeutic implications.
@en
Lysosomal sequestration of amine-containing drugs: analysis and therapeutic implications.
@nl
type
label
Lysosomal sequestration of amine-containing drugs: analysis and therapeutic implications.
@ast
Lysosomal sequestration of amine-containing drugs: analysis and therapeutic implications.
@en
Lysosomal sequestration of amine-containing drugs: analysis and therapeutic implications.
@nl
prefLabel
Lysosomal sequestration of amine-containing drugs: analysis and therapeutic implications.
@ast
Lysosomal sequestration of amine-containing drugs: analysis and therapeutic implications.
@en
Lysosomal sequestration of amine-containing drugs: analysis and therapeutic implications.
@nl
P356
P1476
Lysosomal sequestration of amine-containing drugs: analysis and therapeutic implications.
@en
P2093
Allyn M Kaufmann
Jeffrey P Krise
P304
P356
10.1002/JPS.20792
P407
P577
2007-04-01T00:00:00Z