The metabotropic glutamate receptor subtype 5 antagonist fenobam is analgesic and has improved in vivo selectivity compared with the prototypical antagonist 2-methyl-6-(phenylethynyl)-pyridine
about
Buprenorphine metabolites, buprenorphine-3-glucuronide and norbuprenorphine-3-glucuronide, are biologically activeP-glycoprotein is a major determinant of norbuprenorphine brain exposure and antinociceptionThe glutamatergic system as a target for neuropathic pain reliefSoft, stretchable, fully implantable miniaturized optoelectronic systems for wireless optogenetics.The mGluR5 antagonist fenobam induces analgesic conditioned place preference in mice with spared nerve injuryRET signaling is required for survival and normal function of nonpeptidergic nociceptorsInfluence of stimulant-induced hyperactivity on social approach in the BTBR mouse model of autismMetabotropic glutamate receptors: from the workbench to the bedside.Repetitive self-grooming behavior in the BTBR mouse model of autism is blocked by the mGluR5 antagonist MPEP.Cognitive effects of Group I metabotropic glutamate receptor ligands in the context of drug addiction.Activation of metabotropic glutamate receptor 5 in the amygdala modulates pain-like behavior.mGluR5-antagonist mediated reversal of elevated stereotyped, repetitive behaviors in the VPA model of autismFenobam sulfate inhibits cocaine-taking and cocaine-seeking behavior in rats: implications for addiction treatment in humans.Development of allosteric modulators of GPCRs for treatment of CNS disordersInteractive effects of mGlu5 and 5-HT2A receptors on locomotor activity in miceMetabotropic glutamate receptor 5 regulates excitability and Kv4.2-containing K⁺ channels primarily in excitatory neurons of the spinal dorsal hornSchwann cell mitochondrial metabolism supports long-term axonal survival and peripheral nerve functionMetabotropic glutamate receptor 5 antagonism with fenobam: examination of analgesic tolerance and side effect profile in mice.Differential Modulation of Thresholds for Intracranial Self-Stimulation by mGlu5 Positive and Negative Allosteric Modulators: Implications for Effects on Drug Self-Administration.mGlu receptors and drug addiction.Metabotropic glutamate receptor 5 (mGluR5) regulates bladder nociception.Intracellular mGluR5 plays a critical role in neuropathic painA-kinase anchoring protein 79/150 coordinates metabotropic glutamate receptor sensitization of peripheral sensory neurons.Attenuation of reinstatement of methamphetamine-, sucrose-, and food-seeking behavior in rats by fenobam, a metabotropic glutamate receptor 5 negative allosteric modulator.Dopamine-dependent compensation maintains motor behavior in mice with developmental ablation of dopaminergic neurons.A novel mGluR5 antagonist, MFZ 10-7, inhibits cocaine-taking and cocaine-seeking behavior in rats.Metabotropic glutamate receptor subtype 5 antagonism in learning and memory.Spinal cord mechanisms of chronic pain and clinical implications.Metabotropic glutamate receptors as targets for analgesia: antagonism, activation, and allosteric modulation.Fully implantable, battery-free wireless optoelectronic devices for spinal optogenetics.Pharmacotherapy for Fragile X Syndrome: Progress to Date.Complex behavioral and synaptic effects of dietary branched chain amino acids in a mouse model of amyotrophic lateral sclerosis
P2860
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P2860
The metabotropic glutamate receptor subtype 5 antagonist fenobam is analgesic and has improved in vivo selectivity compared with the prototypical antagonist 2-methyl-6-(phenylethynyl)-pyridine
description
2009 nî lūn-bûn
@nan
2009 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
The metabotropic glutamate rec ...... hyl-6-(phenylethynyl)-pyridine
@ast
The metabotropic glutamate rec ...... hyl-6-(phenylethynyl)-pyridine
@en
The metabotropic glutamate rec ...... hyl-6-(phenylethynyl)-pyridine
@nl
type
label
The metabotropic glutamate rec ...... hyl-6-(phenylethynyl)-pyridine
@ast
The metabotropic glutamate rec ...... hyl-6-(phenylethynyl)-pyridine
@en
The metabotropic glutamate rec ...... hyl-6-(phenylethynyl)-pyridine
@nl
prefLabel
The metabotropic glutamate rec ...... hyl-6-(phenylethynyl)-pyridine
@ast
The metabotropic glutamate rec ...... hyl-6-(phenylethynyl)-pyridine
@en
The metabotropic glutamate rec ...... hyl-6-(phenylethynyl)-pyridine
@nl
P2093
P2860
P356
P1476
The metabotropic glutamate rec ...... hyl-6-(phenylethynyl)-pyridine
@en
P2093
Andrei D Stefanescu
Evan D Kharasch
Kristi K Stubbert
Laura F Cavallone
Michael C Montana
Robert W Gereau
P2860
P304
P356
10.1124/JPET.109.154138
P407
P577
2009-09-01T00:00:00Z