Mice lacking metabotropic glutamate receptor 5 show impaired learning and reduced CA1 long-term potentiation (LTP) but normal CA3 LTP
about
Correction of fragile X syndrome in mice.Importance of Shank3 protein in regulating metabotropic glutamate receptor 5 (mGluR5) expression and signaling at synapsesMetabotropic glutamate receptor 5 is a coreceptor for Alzheimer aβ oligomer bound to cellular prion proteinRare structural variants found in attention-deficit hyperactivity disorder are preferentially associated with neurodevelopmental genesGroup 1 mGluR-dependent synaptic long-term depression: mechanisms and implications for circuitry and diseaseThe metabotropic glutamate receptor subtype 5 antagonist fenobam is analgesic and has improved in vivo selectivity compared with the prototypical antagonist 2-methyl-6-(phenylethynyl)-pyridineSerotonin facilitates long-term depression induction in prefrontal cortex via p38 MAPK/Rab5-mediated enhancement of AMPA receptor internalizationNorbin is an endogenous regulator of metabotropic glutamate receptor 5 signalingPIKE GTPase signaling and functionFluoride and arsenic exposure impairs learning and memory and decreases mGluR5 expression in the hippocampus and cortex in ratsPresynaptic Release-Regulating mGlu1 Receptors in Central Nervous SystemActivation of type 5 metabotropic glutamate receptors enhances NMDA responses in mice cortical wedgesStructural, signalling and regulatory properties of the group I metabotropic glutamate receptors: prototypic family C G-protein-coupled receptorsThe metabotropic glutamate 5 receptor modulates extinction and reinstatement of methamphetamine-seeking in miceFunctional coupling of the metabotropic glutamate receptor, InsP3 receptor and L-type Ca2+ channel in mouse CA1 pyramidal cellsProfilin2 contributes to synaptic vesicle exocytosis, neuronal excitability, and novelty-seeking behaviorEnvironmental Enrichment Ameliorates Behavioral Impairments Modeling Schizophrenia in Mice Lacking Metabotropic Glutamate Receptor 5Disruption of mGluR5 in parvalbumin-positive interneurons induces core features of neurodevelopmental disorders.Cellular, molecular, and genetic substrates underlying the impact of nicotine on learning.Elucidating the role of neurotensin in the pathophysiology and management of major mental disorders.Ablation of Ca2+ channel beta3 subunit leads to enhanced N-methyl-D-aspartate receptor-dependent long term potentiation and improved long term memoryAllosteric modulation of metabotropic glutamate receptors.mGluR5 ablation in cortical glutamatergic neurons increases novelty-induced locomotionInhibition of spontaneous recovery of fear by mGluR5 after prolonged extinction trainingRedundant catecholamine signaling consolidates fear memory via phospholipase C.Forebrain-specific inactivation of Gq/G11 family G proteins results in age-dependent epilepsy and impaired endocannabinoid formationDHPG activation of group 1 mGluRs in BLA enhances fear conditioning.The glutamatergic compounds sarcosine and N-acetylcysteine ameliorate prepulse inhibition deficits in metabotropic glutamate 5 receptor knockout mice.mGluR5 has a critical role in inhibitory learning.Using the MATRICS to guide development of a preclinical cognitive test battery for research in schizophrenia.A mouse model of Down syndrome trisomic for all human chromosome 21 syntenic regions.Deficiencies in the region syntenic to human 21q22.3 cause cognitive deficits in mice.Effects of individual segmental trisomies of human chromosome 21 syntenic regions on hippocampal long-term potentiation and cognitive behaviors in mice.Glutamatergic signaling and low prodynorphin expression are associated with intact memory and reduced anxiety in rat models of healthy agingMetabotropic glutamate receptor 5 knockout reduces cognitive impairment and pathogenesis in a mouse model of Alzheimer's disease.Neurochondrin is a neuronal target antigen in autoimmune cerebellar degeneration.MGluR5 mediates the interaction between late-LTP, network activity, and learningPrenatal restraint stress generates two distinct behavioral and neurochemical profiles in male and female rats.Pharmacological modulation of glutamate transmission in a rat model of L-DOPA-induced dyskinesia: effects on motor behavior and striatal nuclear signalingCyclic AMP and afferent activity govern bidirectional synaptic plasticity in striatopallidal neurons.
P2860
Q22251255-4206C669-8F00-45B6-8B80-77C7330F895AQ24317227-A781F502-8C5D-498C-923A-8F721043E7CAQ24322990-D44D3601-976E-4892-8353-F94C40C7EB02Q24605530-E9F13AAA-C79D-450B-B78F-434F65EACB02Q24620534-E7B88C8E-1FA6-4792-9590-E2C76F453DFFQ24648725-F5326ED3-0D82-4781-A79A-E28D79EF2216Q24653961-5D7ABF50-6865-47AA-BA0D-AB69F59D1000Q24655546-4462750F-93B0-4DB7-A3BF-E0D4561536E5Q24810126-18708960-28F8-4CD2-8F20-8E7EBE86FC49Q27335136-0A988EE5-E936-4EA8-A47C-F38CB9984B7FQ28073858-6E328645-0F63-4E28-B51E-44BE1D9DB276Q28349634-70E4FA9D-3228-4EBE-9967-F652ED67BCFAQ28362372-814658F1-76B3-42D2-9881-2566539D4046Q28534521-AE18D725-C688-4BFB-8420-19613D943EA8Q28591767-AAEE411D-445E-4C9D-8E74-EEC122AC4808Q28592417-28D31A98-9BA6-4A8F-8685-EF15AFC3F122Q30380441-0F0B0F73-8365-4C30-94C8-7079B55804C7Q30402048-B2FE1E4C-DADC-4EF5-9967-D1C6C280A865Q30422037-0103D5B6-7CBC-40E5-B5E8-8DF9A7DF7B70Q30426586-42CF1CB9-613E-4215-B3C6-98C6AACB7942Q30448457-873E4023-A976-4FC9-8EA8-B19B189548EAQ30448534-7831A4F9-F910-4A6B-B694-C3925EBB7C24Q30450936-4A90E165-7A58-4A61-A850-C7B320522E03Q30455712-63542BCA-DF82-4C8C-817A-73BEEE9723D1Q30464844-E5EDF779-F5BD-4411-948D-990953BE64B2Q30478061-5BA95B6F-FCF9-48AE-B2FD-62BCB6A41E09Q30480806-E9EBCFBF-4662-4130-8DDE-1685BD7B1B62Q30481854-EB108C94-2D97-4478-8A96-1BFC1071AA0FQ30486477-503EDD01-09C3-4BD2-BCA8-D23AE17370EFQ30489404-3F5612D4-6ECE-408B-925F-DEB49EEDD953Q30495192-6FB02963-37F5-43B2-944D-84297EB05A33Q30497935-1E2E874E-1FF0-4C79-A945-C7F57FD18883Q30497997-192743A1-D917-4CDA-A726-4871B970B4A4Q30577966-BA23B56B-C56B-4CE9-8F1C-1523F60E40ACQ30580280-EEE8A2E3-CD65-4608-A2D7-AECDE755E276Q30831029-45B156CF-C684-4DDB-AF50-5E4A81507079Q33334354-09BBA2C6-DB2A-4AF6-95C3-85BBAE721DC7Q33334413-91AB9E5B-8C45-4F12-8AA2-06B7C788E91BQ33428476-487A36F3-7AED-4C1E-AC09-0AF5A8E879B1Q33575226-B42C422A-0208-4245-BC1A-18EE9DA90893
P2860
Mice lacking metabotropic glutamate receptor 5 show impaired learning and reduced CA1 long-term potentiation (LTP) but normal CA3 LTP
description
1997 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 1997
@ast
im Juli 1997 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1997/07/01)
@sk
vědecký článek publikovaný v roce 1997
@cs
wetenschappelijk artikel (gepubliceerd op 1997/07/01)
@nl
наукова стаття, опублікована в липні 1997
@uk
مقالة علمية (نشرت في يوليو 1997)
@ar
name
Mice lacking metabotropic glut ...... ation (LTP) but normal CA3 LTP
@ast
Mice lacking metabotropic glut ...... ation (LTP) but normal CA3 LTP
@en
Mice lacking metabotropic glut ...... ation (LTP) but normal CA3 LTP
@nl
type
label
Mice lacking metabotropic glut ...... ation (LTP) but normal CA3 LTP
@ast
Mice lacking metabotropic glut ...... ation (LTP) but normal CA3 LTP
@en
Mice lacking metabotropic glut ...... ation (LTP) but normal CA3 LTP
@nl
prefLabel
Mice lacking metabotropic glut ...... ation (LTP) but normal CA3 LTP
@ast
Mice lacking metabotropic glut ...... ation (LTP) but normal CA3 LTP
@en
Mice lacking metabotropic glut ...... ation (LTP) but normal CA3 LTP
@nl
P2093
P3181
P1476
Mice lacking metabotropic glut ...... ation (LTP) but normal CA3 LTP
@en
P2093
J M Wojtowicz
J T Henderson
P304
P3181
P356
10.1523/JNEUROSCI.17-13-05196.1997
P407
P577
1997-07-01T00:00:00Z