Common missense variant in the glucokinase regulatory protein gene is associated with increased plasma triglyceride and C-reactive protein but lower fasting glucose concentrations
about
Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrationsAssociation of rs780094 in GCKR with metabolic traits and incident diabetes and cardiovascular disease: the ARIC StudyGlucokinase regulatory protein gene polymorphism affects postprandial lipemic response in a dietary intervention studyThe genetics of hyperuricaemia and goutPhysiologic characterization of type 2 diabetes-related lociA weighted false discovery rate control procedure reveals alleles at FOXA2 that influence fasting glucose levelsA genome-wide association study identifies a novel major locus for glycemic control in type 1 diabetes, as measured by both A1C and glucoseVariants in MTNR1B influence fasting glucose levels.Interaction effect of genetic polymorphisms in glucokinase (GCK) and glucokinase regulatory protein (GCKR) on metabolic traits in healthy Chinese adults and adolescentsInsights into the genetic basis of type 2 diabetesGenetic determinants of variability in glycated hemoglobin (HbA(1c)) in humans: review of recent progress and prospects for use in diabetes careNew genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes riskAnalysis of metabolic syndrome components in >15 000 african americans identifies pleiotropic variants: results from the population architecture using genomics and epidemiology studySmall molecule glucokinase activators disturb lipid homeostasis and induce fatty liver in rodents: a warning for therapeutic applications in humansTrans-ethnic Meta-analysis and Functional Annotation Illuminates theĀ Genetic Architecture of Fasting Glucose and Insulin.Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibilityGlucokinase regulatory protein genetic variant interacts with omega-3 PUFA to influence insulin resistance and inflammation in metabolic syndromeGenome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits1000 Genomes-based imputation identifies novel and refined associations for the Wellcome Trust Case Control Consortium phase 1 DataGenetic variation in GIPR influences the glucose and insulin responses to an oral glucose challengeGenotype imputationHuman genetics as a model for target validation: finding new therapies for diabetes.Bridging the gap between genetic associations and molecular mechanisms for type 2 diabetes.Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) conLarge-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes lociLifestyle Intervention for Weight Loss and Cardiometabolic Changes in the Setting of Glucokinase Regulatory Protein Inhibition: Glucokinase Regulatory Protein-Leu446Pro Variant in Look AHEAD.Metabolic syndrome: from epidemiology to systems biology.Evaluation of four novel genetic variants affecting hemoglobin A1c levels in a population-based type 2 diabetes cohort (the HUNT2 study).Identification and characterization of a FOXA2-regulated transcriptional enhancer at a type 2 diabetes intronic locus that controls GCKR expression in liver cells.Uric acid transport and diseaseAssociations of common polymorphisms in GCKR with type 2 diabetes and related traits in a Han Chinese population: a case-control studyMultiancestral analysis of inflammation-related genetic variants and C-reactive protein in the population architecture using genomics and epidemiology study.Multiple functional polymorphisms in the G6PC2 gene contribute to the association with higher fasting plasma glucose levels.Analysis of the co-operative interaction between the allosterically regulated proteins GK and GKRP using tryptophan fluorescenceLess but better: cardioprotective lipid profile of patients with GCK-MODY despite lower HDL cholesterol level.Genetics of type 2 diabetes in European populations.Univariate and bivariate linkage analysis identifies pleiotropic loci underlying lipid levels and type 2 diabetes risk.Cellular characterisation of the GCKR P446L variant associated with type 2 diabetes risk.Evaluating the discriminative power of multi-trait genetic risk scores for type 2 diabetes in a northern Swedish population.Inheritance of rare functional GCKR variants and their contribution to triglyceride levels in families.
P2860
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P2860
Common missense variant in the glucokinase regulatory protein gene is associated with increased plasma triglyceride and C-reactive protein but lower fasting glucose concentrations
description
2008 nĆ® lÅ«n-bĆ»n
@nan
2008 Õ©ÕøÖÕ”ÕÆÕ”Õ¶Õ« ÕÕøÕµÕ„Õ“Õ¢Õ„ÖÕ«Õ¶ Õ°ÖÕ”ÕæÕ”ÖÕ”ÕÆÕøÖÕ”Õ® Õ£Õ«ÕæÕ”ÕÆÕ”Õ¶ ÕµÖ
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@hyw
2008 Õ©Õ¾Õ”ÕÆÕ”Õ¶Õ« Õ¶ÕøÕµÕ„Õ“Õ¢Õ„ÖÕ«Õ¶ Õ°ÖÕ”ÕæÕ”ÖÕ”ÕÆÕ¾Õ”Õ® Õ£Õ«ÕæÕ”ÕÆÕ”Õ¶ Õ°ÕøÕ¤Õ¾Õ”Õ®
@hy
2008幓ć®č«ę
@ja
2008幓č«ę
@yue
2008幓č«ę
@zh-hant
2008幓č«ę
@zh-hk
2008幓č«ę
@zh-mo
2008幓č«ę
@zh-tw
2008幓č®ŗę
@wuu
name
Common missense variant in the ...... fasting glucose concentrations
@ast
Common missense variant in the ...... fasting glucose concentrations
@en
Common missense variant in the ...... fasting glucose concentrations
@en-gb
Common missense variant in the ...... fasting glucose concentrations
@nl
type
label
Common missense variant in the ...... fasting glucose concentrations
@ast
Common missense variant in the ...... fasting glucose concentrations
@en
Common missense variant in the ...... fasting glucose concentrations
@en-gb
Common missense variant in the ...... fasting glucose concentrations
@nl
prefLabel
Common missense variant in the ...... fasting glucose concentrations
@ast
Common missense variant in the ...... fasting glucose concentrations
@en
Common missense variant in the ...... fasting glucose concentrations
@en-gb
Common missense variant in the ...... fasting glucose concentrations
@nl
P2093
P2860
P50
P3181
P356
P1433
P1476
Common missense variant in the ...... fasting glucose concentrations
@en
P2093
Bjƶrn Wahlstrand
Chao-Qiang Lai
Charlotta Roos
Cullan Welch
Dolores Corella
Erkki Vartiainen
Gƶran Berglund
Jennifer Hall
Joel N Hirschhorn
Karl-Fredrik Eriksson
P2860
P304
P3181
P356
10.2337/DB08-0516
P407
P50
P577
2008-11-01T00:00:00Z