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Characterization of glucokinase regulatory protein-deficient mice

Characterization of glucokinase regulatory protein-deficient mice

http://www.wikidata.org/entity/Q28590808

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Association of rs780094 in GCKR with metabolic traits and incident diabetes and cardiovascular disease: the ARIC Study Common missense variant in the glucokinase regulatory protein gene is associated with increased plasma triglyceride and C-reactive protein but lower fasting glucose concentrations Molecular physiology of mammalian glucokinase Genetic background in nonalcoholic fatty liver disease: A comprehensive review Dynamic localization of glucokinase and its regulatory protein in hypothalamic tanycytes Structural Basis for Regulation of Human Glucokinase by Glucokinase Regulatory Protein Antidiabetic effects of glucokinase regulatory protein small-molecule disruptors Contributions of glucokinase and phosphofructokinase-2/fructose bisphosphatase-2 to the elevated glycolysis in hepatocytes from Zucker fa/fa rats Defect in glucokinase translocation in Zucker diabetic fatty rats Identification of fructose 6-phosphate- and fructose 1-phosphate-binding residues in the regulatory protein of glucokinase An allosteric activator of glucokinase impairs the interaction of glucokinase and glucokinase regulatory protein and regulates glucose metabolism Evolution of hepatic glucose metabolism: liver-specific glucokinase deficiency explained by parallel loss of the gene for glucokinase regulatory protein (GCKR)Lifestyle Intervention for Weight Loss and Cardiometabolic Changes in the Setting of Glucokinase Regulatory Protein Inhibition: Glucokinase Regulatory Protein-Leu446Pro Variant in Look AHEAD.Glucotoxicity targets hepatic glucokinase in Zucker diabetic fatty rats, a model of type 2 diabetes associated with obesity.Associations of common polymorphisms in GCKR with type 2 diabetes and related traits in a Han Chinese population: a case-control study Hepatic glucose uptake and disposition during short-term high-fat vs. high-fructose feeding Cellular characterisation of the GCKR P446L variant associated with type 2 diabetes risk.The genetics of insulin resistance: Where's Waldo?Novel polymorphisms in the GCKR gene and their influence on glucose and insulin levels in a Danish twin population.The common P446L polymorphism in GCKR inversely modulates fasting glucose and triglyceride levels and reduces type 2 diabetes risk in the DESIR prospective general French population.Discovery of a novel site regulating glucokinase activity following characterization of a new mutation causing hyperinsulinemic hypoglycemia in humans Gene-altered mice and metabolic flux control.Glucokinase regulatory protein: complexity at the crossroads of triglyceride and glucose metabolism.Role of glucokinase in the subcellular localization of glucokinase regulatory protein.Generation of N-ethyl-N-nitrosourea (ENU) diabetes models in mice demonstrates genotype-specific action of glucokinase activators.Correlation of rare coding variants in the gene encoding human glucokinase regulatory protein with phenotypic, cellular, and kinetic outcomes.Glucokinase links Krüppel-like factor 6 to the regulation of hepatic insulin sensitivity in nonalcoholic fatty liver disease Portal vein glucose entry triggers a coordinated cellular response that potentiates hepatic glucose uptake and storage in normal but not high-fat/high-fructose-fed dogs.Restoration of hepatic glucokinase expression corrects hepatic glucose flux and normalizes plasma glucose in zucker diabetic fatty rats.Proteomic changes associated with diabetes in the BB-DP rat.Normal glucose metabolism in carnivores overlaps with diabetes pathology in non-carnivores.Positive association between GCKR rs780093 polymorphism and coronary heart disease in the aged Han Chinese.Evolution of glucose utilization: glucokinase and glucokinase regulator protein.Molecular targeting of the GK-GKRP pathway in diabetes.The role of tanycytes in hypothalamic glucosensing.Glucagon induces translocation of glucokinase from the cytoplasm to the nucleus of hepatocytes by transfer between 6-phosphofructo 2-kinase/fructose 2,6-bisphosphatase-2 and the glucokinase regulatory protein.Liver Glucokinase(A456V) Induces Potent Hypoglycemia without Dyslipidemia through a Paradoxical Induction of the Catalytic Subunit of Glucose-6-Phosphatase.Association between copy-number variation on metabolic phenotypes and HDL-C levels in patients with polycystic ovary syndrome.The P446L variant in GCKR associated with fasting plasma glucose and triglyceride levels exerts its effect through increased glucokinase activity in liver.Glucokinase thermolability and hepatic regulatory protein binding are essential factors for predicting the blood glucose phenotype of missense mutations.

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P2860

Characterization of glucokinase regulatory protein-deficient mice

http://www.wikidata.org/entity/Q28590808

description

2000 թուականի Մարտին հրատարակուած գիտական յօդուած

@hyw

2000 թվականի մարտին հրատարակված գիտական հոդված

@hy

article publié dans la revue scientifique Journal of Biological Chemistry

@fr

artículu científicu espublizáu en 2000

@ast

im März 2000 veröffentlichter wissenschaftlicher Artikel

@de

scientific journal article

@en

vedecký článok (publikovaný 2000/03/17)

@sk

vědecký článek publikovaný v roce 2000

@cs

wetenschappelijk artikel (gepubliceerd op 2000/03/17)

@nl

наукова стаття, опублікована в березні 2000

@uk

name

Characterization of glucokinase regulatory protein-deficient mice

@ast

Characterization of glucokinase regulatory protein-deficient mice

@en

Characterization of glucokinase regulatory protein-deficient mice

@nl

type

label

Characterization of glucokinase regulatory protein-deficient mice

@ast

Characterization of glucokinase regulatory protein-deficient mice

@en

Characterization of glucokinase regulatory protein-deficient mice

@nl

prefLabel

Characterization of glucokinase regulatory protein-deficient mice

@ast

Characterization of glucokinase regulatory protein-deficient mice

@en

Characterization of glucokinase regulatory protein-deficient mice

@nl

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P356

JBC.275.11.7826

P1433

Journal of Biological Chemistry

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Characterization of glucokinase regulatory protein-deficient mice

@en

P2093

C. Shiota

http://www.w3.org/2001/XMLSchema#string

F. M. Matschinsky

http://www.w3.org/2001/XMLSchema#string

G. Li

http://www.w3.org/2001/XMLSchema#string

J. F. Grippo

http://www.w3.org/2001/XMLSchema#string

J. Grimsby

http://www.w3.org/2001/XMLSchema#string

J. Magram

http://www.w3.org/2001/XMLSchema#string

J. W. Coffey

http://www.w3.org/2001/XMLSchema#string

M. A. Magnuson

http://www.w3.org/2001/XMLSchema#string

M. T. Dvorozniak

http://www.w3.org/2001/XMLSchema#string

S. Kaur

http://www.w3.org/2001/XMLSchema#string

P2860

Pancreatic beta-cell-specific targeted disruption of glucokinase gene. Diabetes mellitus due to defective insulin secretion to glucose

Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase

Nuclear import of hepatic glucokinase depends upon glucokinase regulatory protein, whereas export is due to a nuclear export signal sequence in glucokinase

Animal model for maturity-onset diabetes of the young generated by disruption of the mouse glucokinase gene

Glucokinase regulatory protein is essential for the proper subcellular localisation of liver glucokinase.

Pancreatic beta-cell glucokinase: closing the gap between theoretical concepts and experimental realities.

A protein from rat liver confers to glucokinase the property of being antagonistically regulated by fructose 6-phosphate and fructose 1-phosphate.

Tissue-specific expression of glucokinase: identification of the gene product in liver and pancreatic islets.

Heterogeneous expression of glucokinase among pancreatic beta cells.

Genetics of NIDDM in France: studies with 19 candidate genes in affected sib pairs.

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7826–7831

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10.1074/JBC.275.11.7826

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11

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10713097

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Glucokinase regulatory protein