about
Phosphodiesterase-4 inhibition alters gene expression and improves isoniazid-mediated clearance of Mycobacterium tuberculosis in rabbit lungsPhosphodiesterase 4-targeted treatments for autoimmune diseasesCan the anti-inflammatory potential of PDE4 inhibitors be realized: guarded optimism or wishful thinking?Synthesis, Pharmacological Profile and Docking Studies of New Sulfonamides Designed as Phosphodiesterase-4 InhibitorsPhosphodiesterases as therapeutic targets for Alzheimer's disease.Phosphodiesterase-4 inhibition combined with isoniazid treatment of rabbits with pulmonary tuberculosis reduces macrophage activation and lung pathologySuccessful shortening of tuberculosis treatment using adjuvant host-directed therapy with FDA-approved phosphodiesterase inhibitors in the mouse modelGenome-wide association analysis identifies PDE4D as an asthma-susceptibility geneDevelopment of a high throughput screen for allosteric modulators of melanocortin-4 receptor signaling using a real time cAMP assay.PDE8 regulates rapid Teff cell adhesion and proliferation independent of ICER.A large-scale chemical screen for regulators of the arginase 1 promoter identifies the soy isoflavone daidzeinas a clinically approved small molecule that can promote neuronal protection or regeneration via a cAMP-independent pathway.Elevated cyclic AMP and PDE4 inhibition induce chemokine expression in human monocyte-derived macrophagesEnhancement of the anti-inflammatory and anti-arthritic effects of theophylline by a low dose of a nitric oxide donor or non-specific nitric oxide synthase inhibitorFrom synapse to nucleus: novel targets for treating depression.The inhaled phosphodiesterase 4 inhibitor GSK256066 reduces allergen challenge responses in asthma.Cystic fibrosis transmembrane conductance regulator activation by roflumilast contributes to therapeutic benefit in chronic bronchitis.Nitric oxide/cGMP pathway signaling actively down-regulates α4β1-integrin affinity: an unexpected mechanism for inducing cell de-adhesion.No relevant cardiac, pharmacokinetic or safety interactions between roflumilast and inhaled formoterol in healthy subjects: an open-label, randomised, actively controlled studyApremilast, a cAMP phosphodiesterase-4 inhibitor, demonstrates anti-inflammatory activity in vitro and in a model of psoriasis.Repurposing human PDE4 inhibitors for neglected tropical diseases: design, synthesis and evaluation of cilomilast analogues as Trypanosoma brucei PDEB1 inhibitorsUnraveling the genetic basis of asthma and allergic diseasesExposing rodents to a combination of tobacco smoke and lipopolysaccharide results in an exaggerated inflammatory response in the lung.The in vivo efficacy and side effect pharmacology of GS-5759, a novel bifunctional phosphodiesterase 4 inhibitor and long-acting β 2-adrenoceptor agonist in preclinical animal species.Phosphodiesterase 4B is essential for T(H)2-cell function and development of airway hyperresponsiveness in allergic asthmaThe effect of the novel phosphodiesterase-4 inhibitor MEM 1414 on the allergen induced responses in mild asthmaInhibition of cyclooxygenase-2 prevents adverse effects induced by phosphodiesterase type 4 inhibitors in ratsS-adenosylmethionine decreases lipopolysaccharide-induced phosphodiesterase 4B2 and attenuates tumor necrosis factor expression via cAMP/protein kinase A pathway.Roflumilast inhibits lipopolysaccharide-induced tumor necrosis factor-α and chemokine production by human lung parenchyma.Panax ginseng C.A Meyer root extract for moderate chronic obstructive pulmonary disease (COPD): study protocol for a randomised controlled trialMaternal exposure to secondhand cigarette smoke primes the lung for induction of phosphodiesterase-4D5 isozyme and exacerbated Th2 responses: rolipram attenuates the airway hyperreactivity and muscarinic receptor expression but not lung inflammationPhosphodiesterase-4D Knock-down in the Prefrontal Cortex Alleviates Chronic Unpredictable Stress-Induced Depressive-Like Behaviors and Memory Deficits in MiceRoflumilast inhibits the release of chemokines and TNF-α from human lung macrophages stimulated with lipopolysaccharide.Apremilast, a novel phosphodiesterase 4 (PDE4) inhibitor, regulates inflammation through multiple cAMP downstream effectors.PDE4 inhibition suppresses IL-17-associated immunity in dry eye diseaseInhibition of chlorine-induced lung injury by the type 4 phosphodiesterase inhibitor rolipram.Gene set enrichment analysis unveils the mechanism for the phosphodiesterase 4B control of glucocorticoid response in B-cell lymphoma.Traumatic Brain Injury Upregulates Phosphodiesterase Expression in the Hippocampus.RNA interference-mediated phosphodiesterase 4D splice variants knock-down in the prefrontal cortex produces antidepressant-like and cognition-enhancing effects.The cyclic AMP signaling pathway: Exploring targets for successful drug discovery (Review).Monomethylated-adenines potentiate glucose-induced insulin production and secretion via inhibition of phosphodiesterase activity in rat pancreatic islets.
P2860
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P2860
description
2008 nî lūn-bûn
@nan
2008 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
PDE4 inhibitors: current status
@ast
PDE4 inhibitors: current status
@en
PDE4 inhibitors: current status
@nl
type
label
PDE4 inhibitors: current status
@ast
PDE4 inhibitors: current status
@en
PDE4 inhibitors: current status
@nl
prefLabel
PDE4 inhibitors: current status
@ast
PDE4 inhibitors: current status
@en
PDE4 inhibitors: current status
@nl
P2860
P3181
P356
P1476
PDE4 inhibitors: current status
@en
P2093
P2860
P304
P3181
P356
10.1038/BJP.2008.307
P407
P577
2008-10-01T00:00:00Z