Atomic structure of PDE4: insights into phosphodiesterase mechanism and specificity
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Mechanism for the allosteric regulation of phosphodiesterase 2A deduced from the X-ray structure of a near full-length constructmAKAP assembles a protein kinase A/PDE4 phosphodiesterase cAMP signaling moduleCloning and characterization of a cAMP-specific phosphodiesterase (TbPDE2B) from Trypanosoma brucei.Deletion of phosphodiesterase 4D in mice shortens alpha(2)-adrenoceptor-mediated anesthesia, a behavioral correlate of emesisCrystal structure of phosphodiesterase 9 shows orientation variation of inhibitor 3-isobutyl-1-methylxanthine bindingT cell activation up-regulates cyclic nucleotide phosphodiesterases 8A1 and 7A3Regulation of T-cell activation by phosphodiesterase 4B2 requires its dynamic redistribution during immunological synapse formationPDE4 inhibitors: current statusCrystal structure of phosphodiesterase 4D and inhibitor complex(1)Crystal structures of phosphodiesterases 4 and 5 in complex with inhibitor 3-isobutyl-1-methylxanthine suggest a conformation determinant of inhibitor selectivityStructural insight into substrate specificity of phosphodiesterase 10Crystal Structure and Computational Analyses Provide Insights into the Catalytic Mechanism of 2,4-Diacetylphloroglucinol Hydrolase PhlG from Pseudomonas fluorescensStructures of the four subfamilies of phosphodiesterase-4 provide insight into the selectivity of their inhibitorsCrystal structure of the Leishmania major phosphodiesterase LmjPDEB1 and insight into the design of the parasite-selective inhibitorsConformational Variations of Both Phosphodiesterase-5 and Inhibitors Provide the Structural Basis for the Physiological Effects of Vardenafil and SildenafilStructural basis for the catalytic mechanism of human phosphodiesterase 9Structural Insight into the Mechanism of c-di-GMP Hydrolysis by EAL Domain PhosphodiesterasesA metazoan ortholog of SpoT hydrolyzes ppGpp and functions in starvation responsesFragment-Based Screening for Inhibitors of PDE4A Using Enthalpy Arrays and X-ray CrystallographyStructural basis for the design of selective phosphodiesterase 4B inhibitorsSelective Phosphodiesterase 4B Inhibitors: A ReviewIn vitro PKA phosphorylation-mediated human PDE4A4 activationCrystal structure of a substrate complex of myo-inositol oxygenase, a di-iron oxygenase with a key role in inositol metabolismCharacteristics of photoreceptor PDE (PDE6): similarities and differences to PDE5Identification of overlapping but distinct cAMP and cGMP interaction sites with cyclic nucleotide phosphodiesterase 3A by site-directed mutagenesis and molecular modeling based on crystalline PDE4BAttenuation of the activity of the cAMP-specific phosphodiesterase PDE4A5 by interaction with the immunophilin XAP2beta-Arrestin-mediated PDE4 cAMP phosphodiesterase recruitment regulates beta-adrenoceptor switching from Gs to GiG protein signaling: insights from new structures.A family of phosphodiesterase inhibitors discovered by cocrystallography and scaffold-based drug design.Characterization of TbPDE2A, a novel cyclic nucleotide-specific phosphodiesterase from the protozoan parasite Trypanosoma brucei.Effect of Zn...Zn separation on the hydrolytic activity of model dizinc phosphodiesterases.Scanning peptide array analyses identify overlapping binding sites for the signalling scaffold proteins, beta-arrestin and RACK1, in cAMP-specific phosphodiesterase PDE4D5.Multiple elements jointly determine inhibitor selectivity of cyclic nucleotide phosphodiesterases 4 and 7.Phosphodiesterase Inhibitors as a Therapeutic Approach to Neuroprotection and Repair.Exploration and optimization of substituted triazolothiadiazines and triazolopyridazines as PDE4 inhibitorsABCD of the phosphodiesterase family: interaction and differential activity in COPDCharacterization of a catalytic ligand bridging metal ions in phosphodiesterases 4 and 5 by molecular dynamics simulations and hybrid quantum mechanical/molecular mechanical calculations.PDE4 cAMP phosphodiesterases: modular enzymes that orchestrate signalling cross-talk, desensitization and compartmentalizationGAF domains: cyclic nucleotides come full circle.Long PDE4 cAMP specific phosphodiesterases are activated by protein kinase A-mediated phosphorylation of a single serine residue in Upstream Conserved Region 1 (UCR1)
P2860
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P2860
Atomic structure of PDE4: insights into phosphodiesterase mechanism and specificity
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2000 nî lūn-bûn
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2000 թուականի Յունիսին հրատարակուած գիտական յօդուած
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2000 թվականի հունիսին հրատարակված գիտական հոդված
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2000年の論文
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2000年論文
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2000年論文
@zh-hant
2000年論文
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2000年論文
@zh-mo
2000年論文
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2000年论文
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name
Atomic structure of PDE4: insights into phosphodiesterase mechanism and specificity
@ast
Atomic structure of PDE4: insights into phosphodiesterase mechanism and specificity
@en
Atomic structure of PDE4: insights into phosphodiesterase mechanism and specificity
@nl
type
label
Atomic structure of PDE4: insights into phosphodiesterase mechanism and specificity
@ast
Atomic structure of PDE4: insights into phosphodiesterase mechanism and specificity
@en
Atomic structure of PDE4: insights into phosphodiesterase mechanism and specificity
@nl
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Atomic structure of PDE4: insights into phosphodiesterase mechanism and specificity
@ast
Atomic structure of PDE4: insights into phosphodiesterase mechanism and specificity
@en
Atomic structure of PDE4: insights into phosphodiesterase mechanism and specificity
@nl
P2093
P1433
P1476
Atomic structure of PDE4: insights into phosphodiesterase mechanism and specificity
@en
P2093
A M Hassell
M A Luther
M H Lambert
M V Milburn
W D Holmes
W J Rocque
P304
P356
10.1126/SCIENCE.288.5472.1822
P407
P577
2000-06-01T00:00:00Z