Leishmania trypanothione synthetase-amidase structure reveals a basis for regulation of conflicting synthetic and hydrolytic activities - Wikidata - wikimedia - TriplyDB

Leishmania trypanothione synthetase-amidase structure reveals a basis for regulation of conflicting synthetic and hydrolytic activities

Leishmania trypanothione synthetase-amidase structure reveals a basis for regulation of conflicting synthetic and hydrolytic activities

http://www.wikidata.org/entity/Q24655332

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Dissecting the essentiality of the bifunctional trypanothione synthetase-amidase in Trypanosoma brucei using chemical and genetic methods Chemical validation of trypanothione synthetase: a potential drug target for human trypanosomiasis Recent developments in drug discovery for leishmaniasis and human African trypanosomiasis Structural Basis of Murein Peptide Specificity of a γ-D-Glutamyl-L-Diamino Acid Endopeptidase Specificity and Mechanism ofAcinetobacter baumaniiNicotinamidase: Implications for Activation of the Front-Line Tuberculosis Drug Pyrazinamide Structural Basis for Evolution of Product Diversity in Soybean Glutathione Biosynthesis Structure of Trypanosoma brucei glutathione synthetase: Domain and loop alterations in the catalytic cycle of a highly conserved enzyme Protein S-Thiolation by Glutathionylspermidine (Gsp): THE ROLE OF ESCHERICHIA COLI Gsp SYNTHETASE/AMIDASE IN REDOX REGULATION Structure and mechanism ofEscherichia coliglutathionylspermidine amidase belonging to the family of cysteine; histidine-dependent amidohydrolases/peptidases Structural basis for type VI secreted peptidoglycanDL-endopeptidase function, specificity and neutralization inSerratia marcescens Structures of bacterial kynurenine formamidase reveal a crowded binuclear zinc catalytic site primed to generate a potent nucleophile Regulated expression of an essential allosteric activator of polyamine biosynthesis in African trypanosomes Mathematical modelling of polyamine metabolism in bloodstream-form Trypanosoma brucei: an application to drug target identification Molecular dynamics reveal binding mode of glutathionylspermidine by trypanothione synthetase Structural and biochemical characterization reveals LysGH15 as an unprecedented "EF-hand-like" calcium-binding phage lysin Stage-dependent expression and up-regulation of trypanothione synthetase in amphotericin B resistant Leishmania donovani Identification of Novel Chemical Scaffolds Inhibiting Trypanothione Synthetase from Pathogenic Trypanosomatids Polyamine homoeostasis as a drug target in pathogenic protozoa: peculiarities and possibilities Genetic validation of Trypanosoma brucei glutathione synthetase as an essential enzyme.Design, synthesis and biological evaluation of Trypanosoma brucei trypanothione synthetase inhibitors.RNA interference-mediated silencing of ornithine decarboxylase and spermidine synthase genes in Trypanosoma brucei provides insight into regulation of polyamine biosynthesis.Optimized CGenFF force-field parameters for acylphosphate and N-phosphonosulfonimidoyl functional groups.Polyamine metabolism in Leishmania: from arginine to trypanothione.Structural insights into the enzymes of the trypanothione pathway: targets for antileishmaniasis drugs.Polyamine-trypanothione pathway: an update.Stress-Induced Protein S-Glutathionylation and S-Trypanothionylation in African Trypanosomes-A Quantitative Redox Proteome and Thiol Analysis.An Improved Model of the Trypanosoma brucei CTP Synthetase Glutaminase Domain-Acivicin Complex.In-silico analyses of sesquiterpene-related compounds on selected Leishmania enzyme-based targets.Dissecting the catalytic mechanism of Trypanosoma brucei trypanothione synthetase by kinetic analysis and computational modeling ATP-dependent ligases in trypanothione biosynthesis--kinetics of catalysis and inhibition by phosphinic acid pseudopeptides.Cloning, expression, characterization and inhibition studies on trypanothione synthetase, a drug target enzyme, from Leishmania donovani.Buthionine sulfoximine is a multitarget inhibitor of trypanothione synthesis in Trypanosoma cruzi.

P2860

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P2860

Leishmania trypanothione synthetase-amidase structure reveals a basis for regulation of conflicting synthetic and hydrolytic activities

http://www.wikidata.org/entity/Q24655332

description

2008 nî lūn-bûn

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2008 թուականի Յունիսին հրատարակուած գիտական յօդուած

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2008 թվականի հունիսին հրատարակված գիտական հոդված

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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Leishmania trypanothione synth ...... etic and hydrolytic activities

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Leishmania trypanothione synth ...... etic and hydrolytic activities

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Leishmania trypanothione synth ...... etic and hydrolytic activities

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Leishmania trypanothione synth ...... etic and hydrolytic activities

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Leishmania trypanothione synth ...... etic and hydrolytic activities

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Leishmania trypanothione synth ...... etic and hydrolytic activities

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Leishmania trypanothione synth ...... etic and hydrolytic activities

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Leishmania trypanothione synth ...... etic and hydrolytic activities

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P1433

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P1433

Journal of Biological Chemistry

P1476

Leishmania trypanothione synth ...... etic and hydrolytic activities

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P2093

Paul K Fyfe

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P2860

Genomic analysis of the eukaryotic protein kinase superfamily: a perspective

Phenotypic analysis of trypanothione synthetase knockdown in the African trypanosome

A diverse superfamily of enzymes with ATP-dependent carboxylate-amine/thiol ligase activity

Purification of glutathionylspermidine and trypanothione synthetases from Crithidia fasciculata

Evolutionary history, structural features and biochemical diversity of the NlpC/P60 superfamily of enzymes

PROCHECK: a program to check the stereochemical quality of protein structures

Crystal structure of Trypanosoma cruzi trypanothione reductase in complex with trypanothione, and the structure-based discovery of new natural product inhibitors

The high resolution crystal structure of recombinant Crithidia fasciculata tryparedoxin-I

The structure of reduced tryparedoxin peroxidase reveals a decamer and insight into reactivity of 2Cys-peroxiredoxins

Large conformational changes in the catalytic cycle of glutathione synthase

P304

17672-17680

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scholarly article

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10.1074/JBC.M801850200

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25

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P478

283

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P50

Alan H Fairlamb

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2008-04-17T00:00:00Z

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18420578

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2427367

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